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Gene: PARD3B |
Gene summary for PARD3B |
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Gene information | Species | Human | Gene symbol | PARD3B | Gene ID | 117583 |
Gene name | par-3 family cell polarity regulator beta | |
Gene Alias | ALS2CR19 | |
Cytomap | 2q33.3 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q8TEW8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
117583 | PARD3B | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.88e-55 | -7.90e-01 | 0.0155 |
117583 | PARD3B | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.24e-05 | -5.67e-01 | 0.0216 |
117583 | PARD3B | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.37e-19 | -6.39e-01 | -0.1207 |
117583 | PARD3B | HTA11_5212_2000001011 | Human | Colorectum | AD | 7.70e-03 | -3.74e-01 | -0.2061 |
117583 | PARD3B | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.47e-08 | -6.37e-01 | -0.1462 |
117583 | PARD3B | HTA11_546_2000001011 | Human | Colorectum | AD | 2.34e-02 | -4.31e-01 | -0.0842 |
117583 | PARD3B | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.84e-03 | -4.76e-01 | -0.00410000000000005 |
117583 | PARD3B | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.48e-03 | -3.32e-01 | -0.0179 |
117583 | PARD3B | HTA11_866_3004761011 | Human | Colorectum | AD | 8.54e-33 | -7.06e-01 | 0.096 |
117583 | PARD3B | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.22e-05 | -7.23e-01 | 0.0451 |
117583 | PARD3B | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.33e-23 | -8.95e-01 | 0.0528 |
117583 | PARD3B | HTA11_10623_2000001011 | Human | Colorectum | AD | 6.62e-03 | -4.39e-01 | -0.0177 |
117583 | PARD3B | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.94e-02 | -3.18e-01 | 0.0338 |
117583 | PARD3B | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.28e-04 | -4.53e-01 | 0.0112 |
117583 | PARD3B | HTA11_11156_2000001011 | Human | Colorectum | AD | 6.22e-04 | -4.94e-01 | 0.0397 |
117583 | PARD3B | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.65e-27 | -5.87e-01 | 0.294 |
117583 | PARD3B | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.41e-06 | -4.50e-01 | 0.281 |
117583 | PARD3B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.07e-12 | -5.03e-01 | 0.3859 |
117583 | PARD3B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.60e-13 | -5.09e-01 | 0.3005 |
117583 | PARD3B | A001-C-207 | Human | Colorectum | FAP | 1.82e-03 | -3.00e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0007163 | Colorectum | AD | establishment or maintenance of cell polarity | 77/3918 | 218/18723 | 5.72e-07 | 2.08e-05 | 77 |
GO:0030010 | Colorectum | AD | establishment of cell polarity | 50/3918 | 143/18723 | 6.90e-05 | 1.11e-03 | 50 |
GO:0045197 | Colorectum | AD | establishment or maintenance of epithelial cell apical/basal polarity | 20/3918 | 44/18723 | 2.26e-04 | 2.94e-03 | 20 |
GO:0035088 | Colorectum | AD | establishment or maintenance of apical/basal cell polarity | 21/3918 | 49/18723 | 4.31e-04 | 4.82e-03 | 21 |
GO:0061245 | Colorectum | AD | establishment or maintenance of bipolar cell polarity | 21/3918 | 49/18723 | 4.31e-04 | 4.82e-03 | 21 |
GO:0051660 | Colorectum | AD | establishment of centrosome localization | 7/3918 | 10/18723 | 1.15e-03 | 1.04e-02 | 7 |
GO:00516561 | Colorectum | SER | establishment of organelle localization | 100/2897 | 390/18723 | 1.11e-07 | 6.79e-06 | 100 |
GO:00071631 | Colorectum | SER | establishment or maintenance of cell polarity | 60/2897 | 218/18723 | 3.45e-06 | 1.33e-04 | 60 |
GO:00451971 | Colorectum | SER | establishment or maintenance of epithelial cell apical/basal polarity | 16/2897 | 44/18723 | 5.64e-04 | 7.83e-03 | 16 |
GO:00350881 | Colorectum | SER | establishment or maintenance of apical/basal cell polarity | 17/2897 | 49/18723 | 7.17e-04 | 9.44e-03 | 17 |
GO:00612451 | Colorectum | SER | establishment or maintenance of bipolar cell polarity | 17/2897 | 49/18723 | 7.17e-04 | 9.44e-03 | 17 |
GO:00300101 | Colorectum | SER | establishment of cell polarity | 37/2897 | 143/18723 | 8.72e-04 | 1.06e-02 | 37 |
GO:00516562 | Colorectum | MSS | establishment of organelle localization | 115/3467 | 390/18723 | 7.30e-08 | 3.67e-06 | 115 |
GO:00071632 | Colorectum | MSS | establishment or maintenance of cell polarity | 72/3467 | 218/18723 | 1.90e-07 | 8.30e-06 | 72 |
GO:00300102 | Colorectum | MSS | establishment of cell polarity | 47/3467 | 143/18723 | 2.74e-05 | 5.58e-04 | 47 |
GO:00451972 | Colorectum | MSS | establishment or maintenance of epithelial cell apical/basal polarity | 19/3467 | 44/18723 | 1.38e-04 | 2.06e-03 | 19 |
GO:00350882 | Colorectum | MSS | establishment or maintenance of apical/basal cell polarity | 20/3467 | 49/18723 | 2.36e-04 | 3.24e-03 | 20 |
GO:00612452 | Colorectum | MSS | establishment or maintenance of bipolar cell polarity | 20/3467 | 49/18723 | 2.36e-04 | 3.24e-03 | 20 |
GO:00516601 | Colorectum | MSS | establishment of centrosome localization | 7/3467 | 10/18723 | 5.26e-04 | 5.99e-03 | 7 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PARD3B | insertion | Frame_Shift_Ins | novel | c.377_378insA | p.Ser127PhefsTer16 | p.S127Ffs*16 | Q8TEW8 | protein_coding | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PARD3B | insertion | Frame_Shift_Ins | novel | c.1465_1466dupCT | p.Glu490TrpfsTer13 | p.E490Wfs*13 | Q8TEW8 | protein_coding | TCGA-B5-A0JV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
PARD3B | insertion | Frame_Shift_Ins | novel | c.764_765insA | p.Ile257AsnfsTer38 | p.I257Nfs*38 | Q8TEW8 | protein_coding | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PARD3B | insertion | Frame_Shift_Ins | rs767379015 | c.2581_2582insCA | p.Glu861AlafsTer8 | p.E861Afs*8 | Q8TEW8 | protein_coding | TCGA-D1-A102-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PARD3B | insertion | Frame_Shift_Ins | novel | c.1235_1236insA | p.Asn414LysfsTer70 | p.N414Kfs*70 | Q8TEW8 | protein_coding | TCGA-EO-A22S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PARD3B | SNV | Missense_Mutation | c.247N>A | p.Glu83Lys | p.E83K | Q8TEW8 | protein_coding | tolerated(0.13) | possibly_damaging(0.856) | TCGA-CC-A5UE-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
PARD3B | SNV | Missense_Mutation | c.1199N>T | p.Arg400Ile | p.R400I | Q8TEW8 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
PARD3B | SNV | Missense_Mutation | novel | c.175N>A | p.Leu59Met | p.L59M | Q8TEW8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
PARD3B | SNV | Missense_Mutation | novel | c.3257N>A | p.Pro1086His | p.P1086H | Q8TEW8 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
PARD3B | SNV | Missense_Mutation | c.2207G>T | p.Gly736Val | p.G736V | Q8TEW8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-44-7672-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
117583 | PARD3B | NA | oxaliplatin | OXALIPLATIN | 22310351 | |
117583 | PARD3B | NA | fluorouracil | FLUOROURACIL | 22310351 |
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