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Gene: PAPLN |
Gene summary for PAPLN |
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Gene information | Species | Human | Gene symbol | PAPLN | Gene ID | 89932 |
Gene name | papilin, proteoglycan like sulfated glycoprotein | |
Gene Alias | PPN | |
Cytomap | 14q24.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | B3KXI1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
89932 | PAPLN | male-WTA | Human | Thyroid | PTC | 1.21e-24 | 2.92e-01 | 0.1037 |
89932 | PAPLN | PTC01 | Human | Thyroid | PTC | 1.24e-09 | 1.93e-01 | 0.1899 |
89932 | PAPLN | PTC04 | Human | Thyroid | PTC | 1.50e-26 | 5.35e-01 | 0.1927 |
89932 | PAPLN | PTC05 | Human | Thyroid | PTC | 3.01e-16 | 5.63e-01 | 0.2065 |
89932 | PAPLN | PTC06 | Human | Thyroid | PTC | 5.23e-29 | 6.59e-01 | 0.2057 |
89932 | PAPLN | PTC07 | Human | Thyroid | PTC | 9.63e-25 | 3.54e-01 | 0.2044 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0052547113 | Thyroid | PTC | regulation of peptidase activity | 191/5968 | 461/18723 | 7.82e-06 | 9.02e-05 | 191 |
GO:0052548113 | Thyroid | PTC | regulation of endopeptidase activity | 174/5968 | 432/18723 | 1.20e-04 | 9.55e-04 | 174 |
GO:00301986 | Thyroid | PTC | extracellular matrix organization | 124/5968 | 301/18723 | 3.75e-04 | 2.53e-03 | 124 |
GO:00430626 | Thyroid | PTC | extracellular structure organization | 124/5968 | 302/18723 | 4.38e-04 | 2.92e-03 | 124 |
GO:00452296 | Thyroid | PTC | external encapsulating structure organization | 124/5968 | 304/18723 | 5.96e-04 | 3.79e-03 | 124 |
GO:0051346112 | Thyroid | PTC | negative regulation of hydrolase activity | 146/5968 | 379/18723 | 3.33e-03 | 1.62e-02 | 146 |
GO:0045861113 | Thyroid | PTC | negative regulation of proteolysis | 136/5968 | 351/18723 | 3.54e-03 | 1.71e-02 | 136 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAPLN | SNV | Missense_Mutation | c.563N>T | p.Thr188Ile | p.T188I | O95428 | protein_coding | tolerated(0.08) | benign(0.084) | TCGA-66-2757-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | gemcitabine | PD | |
PAPLN | SNV | Missense_Mutation | novel | c.1426N>A | p.Gly476Ser | p.G476S | O95428 | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-77-7337-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PAPLN | SNV | Missense_Mutation | novel | c.839G>T | p.Ser280Ile | p.S280I | O95428 | protein_coding | tolerated(0.2) | possibly_damaging(0.576) | TCGA-94-8491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
PAPLN | SNV | Missense_Mutation | novel | c.715G>A | p.Glu239Lys | p.E239K | O95428 | protein_coding | deleterious(0.02) | probably_damaging(0.939) | TCGA-NC-A5HD-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PAPLN | deletion | Frame_Shift_Del | c.1539delN | p.Gln515ArgfsTer260 | p.Q515Rfs*260 | O95428 | protein_coding | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD | |||
PAPLN | SNV | Missense_Mutation | rs200690849 | c.973N>T | p.Arg325Trp | p.R325W | O95428 | protein_coding | deleterious(0.01) | probably_damaging(0.951) | TCGA-EJ-5499-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
PAPLN | SNV | Missense_Mutation | rs752415617 | c.976C>T | p.Arg326Cys | p.R326C | O95428 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-H9-7775-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD |
PAPLN | SNV | Missense_Mutation | rs757481136 | c.1825N>A | p.Gly609Arg | p.G609R | O95428 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PAPLN | SNV | Missense_Mutation | rs550935233 | c.3050N>A | p.Arg1017His | p.R1017H | O95428 | protein_coding | deleterious(0.05) | benign(0.038) | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PAPLN | SNV | Missense_Mutation | rs763873503 | c.649C>T | p.Arg217Trp | p.R217W | O95428 | protein_coding | tolerated(0.05) | benign(0.035) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
89932 | PAPLN | PROTEASE INHIBITOR | citalopram | CITALOPRAM |
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