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Gene: PAMR1 |
Gene summary for PAMR1 |
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Gene information | Species | Human | Gene symbol | PAMR1 | Gene ID | 25891 |
Gene name | peptidase domain containing associated with muscle regeneration 1 | |
Gene Alias | DKFZP586H2123 | |
Cytomap | 11p13 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6UXH9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25891 | PAMR1 | AEH-subject1 | Human | Endometrium | AEH | 2.58e-31 | -6.35e-01 | -0.3059 |
25891 | PAMR1 | AEH-subject2 | Human | Endometrium | AEH | 8.27e-34 | -6.36e-01 | -0.2525 |
25891 | PAMR1 | AEH-subject3 | Human | Endometrium | AEH | 1.71e-19 | -5.47e-01 | -0.2576 |
25891 | PAMR1 | AEH-subject4 | Human | Endometrium | AEH | 1.51e-05 | -2.48e-01 | -0.2657 |
25891 | PAMR1 | AEH-subject5 | Human | Endometrium | AEH | 5.72e-35 | -6.71e-01 | -0.2953 |
25891 | PAMR1 | EEC-subject1 | Human | Endometrium | EEC | 4.11e-40 | -6.59e-01 | -0.2682 |
25891 | PAMR1 | EEC-subject2 | Human | Endometrium | EEC | 2.45e-36 | -6.81e-01 | -0.2607 |
25891 | PAMR1 | EEC-subject3 | Human | Endometrium | EEC | 2.42e-38 | -6.60e-01 | -0.2525 |
25891 | PAMR1 | EEC-subject4 | Human | Endometrium | EEC | 5.01e-30 | -5.92e-01 | -0.2571 |
25891 | PAMR1 | EEC-subject5 | Human | Endometrium | EEC | 1.23e-39 | -6.79e-01 | -0.249 |
25891 | PAMR1 | GSM5276934 | Human | Endometrium | EEC | 1.23e-04 | -3.22e-01 | -0.0913 |
25891 | PAMR1 | GSM5276935 | Human | Endometrium | EEC | 1.36e-43 | -6.87e-01 | -0.123 |
25891 | PAMR1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.08e-34 | -6.89e-01 | -0.1869 |
25891 | PAMR1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 4.28e-31 | -6.89e-01 | -0.1875 |
25891 | PAMR1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 7.56e-36 | -6.89e-01 | -0.1883 |
25891 | PAMR1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.03e-42 | -6.89e-01 | -0.1934 |
25891 | PAMR1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.36e-43 | -6.89e-01 | -0.1917 |
25891 | PAMR1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.05e-45 | -6.89e-01 | -0.1916 |
25891 | PAMR1 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 9.60e-08 | -3.48e-01 | -0.1269 |
25891 | PAMR1 | C38 | Human | Oral cavity | OSCC | 1.28e-11 | 8.20e-01 | 0.172 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAMR1 | SNV | Missense_Mutation | novel | c.1446N>C | p.Gln482His | p.Q482H | Q6UXH9 | protein_coding | tolerated(0.5) | probably_damaging(0.927) | TCGA-CN-A6V1-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Immunotherapy | erbitux | CR |
PAMR1 | SNV | Missense_Mutation | novel | c.986C>G | p.Ser329Cys | p.S329C | Q6UXH9 | protein_coding | tolerated(0.08) | benign(0.416) | TCGA-CR-7364-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
PAMR1 | SNV | Missense_Mutation | c.1625N>A | p.Gly542Glu | p.G542E | Q6UXH9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CV-7252-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
PAMR1 | deletion | Frame_Shift_Del | c.302delN | p.Gly101ValfsTer8 | p.G101Vfs*8 | Q6UXH9 | protein_coding | TCGA-QK-A6VB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |||
PAMR1 | SNV | Missense_Mutation | novel | c.245N>T | p.His82Leu | p.H82L | Q6UXH9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-J4-A83M-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | PD |
PAMR1 | SNV | Missense_Mutation | rs371928843 | c.959G>A | p.Arg320His | p.R320H | Q6UXH9 | protein_coding | tolerated(0.57) | benign(0.001) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PAMR1 | SNV | Missense_Mutation | rs372889720 | c.1433N>A | p.Arg478His | p.R478H | Q6UXH9 | protein_coding | tolerated(0.33) | benign(0.007) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PAMR1 | SNV | Missense_Mutation | c.329N>C | p.Gly110Ala | p.G110A | Q6UXH9 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-BR-4294-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PAMR1 | SNV | Missense_Mutation | c.1556C>T | p.Ala519Val | p.A519V | Q6UXH9 | protein_coding | tolerated(0.09) | possibly_damaging(0.572) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAMR1 | SNV | Missense_Mutation | c.1571N>T | p.Thr524Ile | p.T524I | Q6UXH9 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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