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Gene: OVOS2 |
Gene summary for OVOS2 |
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Gene information | Species | Human | Gene symbol | OVOS2 | Gene ID | 144203 |
Gene name | alpha-2-macroglobulin like 1 pseudogene | |
Gene Alias | OVOS2 | |
Cytomap | 12p11.21 | |
Gene Type | pseudo | GO ID | GO:0006508 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
144203 | OVOS2 | GSM4909281 | Human | Breast | IDC | 3.30e-12 | -5.66e-01 | 0.21 |
144203 | OVOS2 | GSM4909282 | Human | Breast | IDC | 1.49e-12 | -5.66e-01 | -0.0288 |
144203 | OVOS2 | GSM4909285 | Human | Breast | IDC | 7.27e-12 | -5.66e-01 | 0.21 |
144203 | OVOS2 | GSM4909286 | Human | Breast | IDC | 1.49e-12 | -5.66e-01 | 0.1081 |
144203 | OVOS2 | GSM4909287 | Human | Breast | IDC | 1.12e-14 | -5.66e-01 | 0.2057 |
144203 | OVOS2 | GSM4909288 | Human | Breast | IDC | 1.24e-02 | -5.66e-01 | 0.0988 |
144203 | OVOS2 | GSM4909290 | Human | Breast | IDC | 3.25e-10 | -5.66e-01 | 0.2096 |
144203 | OVOS2 | GSM4909291 | Human | Breast | IDC | 4.44e-08 | -5.66e-01 | 0.1753 |
144203 | OVOS2 | GSM4909293 | Human | Breast | IDC | 1.60e-11 | -5.66e-01 | 0.1581 |
144203 | OVOS2 | GSM4909294 | Human | Breast | IDC | 3.30e-12 | -5.66e-01 | 0.2022 |
144203 | OVOS2 | GSM4909295 | Human | Breast | IDC | 4.00e-06 | -5.66e-01 | 0.0898 |
144203 | OVOS2 | GSM4909296 | Human | Breast | IDC | 7.27e-12 | -5.66e-01 | 0.1524 |
144203 | OVOS2 | GSM4909297 | Human | Breast | IDC | 6.74e-13 | -5.66e-01 | 0.1517 |
144203 | OVOS2 | GSM4909298 | Human | Breast | IDC | 3.30e-12 | -5.66e-01 | 0.1551 |
144203 | OVOS2 | GSM4909299 | Human | Breast | IDC | 1.49e-12 | -5.66e-01 | 0.035 |
144203 | OVOS2 | GSM4909300 | Human | Breast | IDC | 2.78e-05 | -5.66e-01 | 0.0334 |
144203 | OVOS2 | GSM4909301 | Human | Breast | IDC | 6.74e-13 | -5.66e-01 | 0.1577 |
144203 | OVOS2 | GSM4909302 | Human | Breast | IDC | 1.89e-14 | -5.66e-01 | 0.1545 |
144203 | OVOS2 | GSM4909303 | Human | Breast | IDC | 3.82e-03 | -5.66e-01 | 0.0438 |
144203 | OVOS2 | GSM4909304 | Human | Breast | IDC | 3.04e-13 | -5.66e-01 | 0.1636 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00525479 | Breast | Precancer | regulation of peptidase activity | 71/1080 | 461/18723 | 2.72e-14 | 6.94e-12 | 71 |
GO:00525489 | Breast | Precancer | regulation of endopeptidase activity | 67/1080 | 432/18723 | 1.06e-13 | 2.36e-11 | 67 |
GO:00458619 | Breast | Precancer | negative regulation of proteolysis | 50/1080 | 351/18723 | 2.99e-09 | 2.39e-07 | 50 |
GO:00513468 | Breast | Precancer | negative regulation of hydrolase activity | 50/1080 | 379/18723 | 3.85e-08 | 2.34e-06 | 50 |
GO:00104668 | Breast | Precancer | negative regulation of peptidase activity | 38/1080 | 262/18723 | 1.46e-07 | 7.82e-06 | 38 |
GO:00109519 | Breast | Precancer | negative regulation of endopeptidase activity | 37/1080 | 252/18723 | 1.55e-07 | 8.05e-06 | 37 |
GO:005254714 | Breast | IDC | regulation of peptidase activity | 96/1434 | 461/18723 | 7.58e-20 | 6.15e-17 | 96 |
GO:005254814 | Breast | IDC | regulation of endopeptidase activity | 88/1434 | 432/18723 | 1.20e-17 | 4.85e-15 | 88 |
GO:004586114 | Breast | IDC | negative regulation of proteolysis | 70/1434 | 351/18723 | 8.21e-14 | 2.22e-11 | 70 |
GO:005134613 | Breast | IDC | negative regulation of hydrolase activity | 71/1434 | 379/18723 | 1.33e-12 | 2.90e-10 | 71 |
GO:001046613 | Breast | IDC | negative regulation of peptidase activity | 56/1434 | 262/18723 | 1.39e-12 | 2.92e-10 | 56 |
GO:001095112 | Breast | IDC | negative regulation of endopeptidase activity | 52/1434 | 252/18723 | 3.53e-11 | 5.57e-09 | 52 |
GO:005254723 | Breast | DCIS | regulation of peptidase activity | 88/1390 | 461/18723 | 1.18e-16 | 4.78e-14 | 88 |
GO:005254823 | Breast | DCIS | regulation of endopeptidase activity | 83/1390 | 432/18723 | 6.07e-16 | 2.15e-13 | 83 |
GO:004586123 | Breast | DCIS | negative regulation of proteolysis | 63/1390 | 351/18723 | 4.39e-11 | 6.06e-09 | 63 |
GO:005134623 | Breast | DCIS | negative regulation of hydrolase activity | 64/1390 | 379/18723 | 4.32e-10 | 4.80e-08 | 64 |
GO:001046622 | Breast | DCIS | negative regulation of peptidase activity | 49/1390 | 262/18723 | 1.54e-09 | 1.43e-07 | 49 |
GO:001095122 | Breast | DCIS | negative regulation of endopeptidase activity | 47/1390 | 252/18723 | 3.63e-09 | 3.11e-07 | 47 |
GO:0052547111 | Esophagus | ESCC | regulation of peptidase activity | 275/8552 | 461/18723 | 7.54e-10 | 1.88e-08 | 275 |
GO:0052548111 | Esophagus | ESCC | regulation of endopeptidase activity | 253/8552 | 432/18723 | 3.68e-08 | 6.78e-07 | 253 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OVOS2 | insertion | Frame_Shift_Ins | novel | c.1676_1677insGCTCTGTCACCCAGGATGGAGTGTAGTGGCACGATCT | p.Gly560LeufsTer17 | p.G560Lfs*17 | protein_coding | TCGA-B5-A11F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | |||
OVOS2 | SNV | Missense_Mutation | novel | c.1936N>A | p.Asp646Asn | p.D646N | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-44-2656-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
OVOS2 | SNV | Missense_Mutation | novel | c.1436N>T | p.Ser479Ile | p.S479I | protein_coding | tolerated(0.35) | benign(0.06) | TCGA-44-3918-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
OVOS2 | SNV | Missense_Mutation | novel | c.1735N>C | p.Ala579Pro | p.A579P | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-44-7662-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
OVOS2 | SNV | Missense_Mutation | novel | c.1244G>C | p.Trp415Ser | p.W415S | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-49-6745-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | unknown | SD | |
OVOS2 | SNV | Missense_Mutation | novel | c.2187G>T | p.Trp729Cys | p.W729C | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-7907-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
OVOS2 | SNV | Missense_Mutation | novel | c.2224N>G | p.Leu742Val | p.L742V | protein_coding | tolerated(0.38) | benign(0.169) | TCGA-55-A4DF-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
OVOS2 | SNV | Missense_Mutation | novel | c.1204G>C | p.Ala402Pro | p.A402P | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-62-A46S-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | tarceva | PD | |
OVOS2 | SNV | Missense_Mutation | novel | c.1754T>C | p.Leu585Pro | p.L585P | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-78-7150-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD | |
OVOS2 | SNV | Missense_Mutation | c.2695N>C | p.Glu899Gln | p.E899Q | protein_coding | deleterious(0.01) | probably_damaging(0.925) | TCGA-78-7152-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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