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Gene: OSBPL8 |
Gene summary for OSBPL8 |
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Gene information | Species | Human | Gene symbol | OSBPL8 | Gene ID | 114882 |
Gene name | oxysterol binding protein like 8 | |
Gene Alias | MST120 | |
Cytomap | 12q21.2 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q5HYM3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114882 | OSBPL8 | CA_HPV_1 | Human | Cervix | CC | 1.79e-06 | -2.16e-01 | 0.0264 |
114882 | OSBPL8 | CCI_2 | Human | Cervix | CC | 4.99e-06 | 6.05e-01 | 0.5249 |
114882 | OSBPL8 | CCII_1 | Human | Cervix | CC | 1.09e-10 | -6.13e-01 | 0.3249 |
114882 | OSBPL8 | Tumor | Human | Cervix | CC | 9.77e-19 | -5.28e-01 | 0.1241 |
114882 | OSBPL8 | sample1 | Human | Cervix | CC | 2.03e-03 | -4.83e-01 | 0.0959 |
114882 | OSBPL8 | sample3 | Human | Cervix | CC | 1.24e-14 | -4.38e-01 | 0.1387 |
114882 | OSBPL8 | H2 | Human | Cervix | HSIL_HPV | 1.14e-08 | -3.61e-01 | 0.0632 |
114882 | OSBPL8 | L1 | Human | Cervix | CC | 9.00e-09 | -4.87e-01 | 0.0802 |
114882 | OSBPL8 | T1 | Human | Cervix | CC | 1.19e-11 | -5.14e-01 | 0.0918 |
114882 | OSBPL8 | T3 | Human | Cervix | CC | 4.72e-14 | -4.21e-01 | 0.1389 |
114882 | OSBPL8 | LZE4T | Human | Esophagus | ESCC | 8.60e-18 | 5.71e-01 | 0.0811 |
114882 | OSBPL8 | LZE5T | Human | Esophagus | ESCC | 5.94e-05 | 4.97e-01 | 0.0514 |
114882 | OSBPL8 | LZE7T | Human | Esophagus | ESCC | 2.61e-06 | 5.05e-01 | 0.0667 |
114882 | OSBPL8 | LZE8T | Human | Esophagus | ESCC | 3.13e-04 | -8.14e-03 | 0.067 |
114882 | OSBPL8 | LZE20T | Human | Esophagus | ESCC | 1.54e-05 | 1.61e-01 | 0.0662 |
114882 | OSBPL8 | LZE22D1 | Human | Esophagus | HGIN | 2.06e-06 | 7.18e-02 | 0.0595 |
114882 | OSBPL8 | LZE22T | Human | Esophagus | ESCC | 3.02e-04 | 2.21e-01 | 0.068 |
114882 | OSBPL8 | LZE24T | Human | Esophagus | ESCC | 4.02e-14 | 3.84e-01 | 0.0596 |
114882 | OSBPL8 | LZE21T | Human | Esophagus | ESCC | 7.15e-08 | 3.09e-01 | 0.0655 |
114882 | OSBPL8 | LZE6T | Human | Esophagus | ESCC | 6.73e-06 | 1.20e-01 | 0.0845 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00512359 | Cervix | CC | maintenance of location | 78/2311 | 327/18723 | 5.18e-09 | 4.92e-07 | 78 |
GO:003367410 | Cervix | CC | positive regulation of kinase activity | 101/2311 | 467/18723 | 8.66e-09 | 7.22e-07 | 101 |
GO:00458608 | Cervix | CC | positive regulation of protein kinase activity | 85/2311 | 386/18723 | 5.61e-08 | 3.29e-06 | 85 |
GO:00345048 | Cervix | CC | protein localization to nucleus | 68/2311 | 290/18723 | 9.91e-08 | 5.25e-06 | 68 |
GO:00454445 | Cervix | CC | fat cell differentiation | 53/2311 | 229/18723 | 3.72e-06 | 9.75e-05 | 53 |
GO:19016538 | Cervix | CC | cellular response to peptide | 72/2311 | 359/18723 | 1.89e-05 | 3.48e-04 | 72 |
GO:00512713 | Cervix | CC | negative regulation of cellular component movement | 73/2311 | 367/18723 | 2.22e-05 | 3.95e-04 | 73 |
GO:00400133 | Cervix | CC | negative regulation of locomotion | 76/2311 | 391/18723 | 3.47e-05 | 5.60e-04 | 76 |
GO:20001463 | Cervix | CC | negative regulation of cell motility | 71/2311 | 359/18723 | 3.47e-05 | 5.60e-04 | 71 |
GO:00303363 | Cervix | CC | negative regulation of cell migration | 68/2311 | 344/18723 | 5.11e-05 | 7.70e-04 | 68 |
GO:00434349 | Cervix | CC | response to peptide hormone | 77/2311 | 414/18723 | 1.40e-04 | 1.70e-03 | 77 |
GO:00713757 | Cervix | CC | cellular response to peptide hormone stimulus | 57/2311 | 290/18723 | 2.32e-04 | 2.59e-03 | 57 |
GO:00328698 | Cervix | CC | cellular response to insulin stimulus | 42/2311 | 203/18723 | 4.95e-04 | 4.83e-03 | 42 |
GO:00518964 | Cervix | CC | regulation of protein kinase B signaling | 39/2311 | 185/18723 | 5.25e-04 | 5.10e-03 | 39 |
GO:00518973 | Cervix | CC | positive regulation of protein kinase B signaling | 28/2311 | 120/18723 | 5.90e-04 | 5.59e-03 | 28 |
GO:00434913 | Cervix | CC | protein kinase B signaling | 43/2311 | 211/18723 | 5.95e-04 | 5.60e-03 | 43 |
GO:00328688 | Cervix | CC | response to insulin | 50/2311 | 264/18723 | 1.28e-03 | 1.02e-02 | 50 |
GO:00108834 | Cervix | CC | regulation of lipid storage | 15/2311 | 57/18723 | 3.13e-03 | 2.05e-02 | 15 |
GO:00082865 | Cervix | CC | insulin receptor signaling pathway | 25/2311 | 116/18723 | 3.59e-03 | 2.30e-02 | 25 |
GO:00347645 | Cervix | CC | positive regulation of transmembrane transport | 40/2311 | 219/18723 | 6.97e-03 | 3.76e-02 | 40 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OSBPL8 | SNV | Missense_Mutation | novel | c.561G>T | p.Trp187Cys | p.W187C | Q9BZF1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BA-4078-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
OSBPL8 | SNV | Missense_Mutation | novel | c.475G>A | p.Gly159Ser | p.G159S | Q9BZF1 | protein_coding | tolerated(0.07) | possibly_damaging(0.905) | TCGA-CV-7254-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
OSBPL8 | SNV | Missense_Mutation | novel | c.2266N>A | p.Asp756Asn | p.D756N | Q9BZF1 | protein_coding | deleterious(0.01) | probably_damaging(0.951) | TCGA-CV-7425-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
OSBPL8 | SNV | Missense_Mutation | novel | c.112N>G | p.Leu38Val | p.L38V | Q9BZF1 | protein_coding | deleterious_low_confidence(0.02) | benign(0) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
OSBPL8 | SNV | Missense_Mutation | novel | c.2473A>G | p.Ile825Val | p.I825V | Q9BZF1 | protein_coding | tolerated(0.61) | benign(0) | TCGA-DQ-5630-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
OSBPL8 | SNV | Missense_Mutation | novel | c.197C>T | p.Pro66Leu | p.P66L | Q9BZF1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.981) | TCGA-HC-A6AQ-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
OSBPL8 | SNV | Missense_Mutation | c.1072N>A | p.Ser358Thr | p.S358T | Q9BZF1 | protein_coding | tolerated(0.11) | benign(0.168) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
OSBPL8 | SNV | Missense_Mutation | c.1695N>A | p.Asp565Glu | p.D565E | Q9BZF1 | protein_coding | tolerated(0.36) | benign(0.013) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
OSBPL8 | SNV | Missense_Mutation | c.1079G>A | p.Arg360Lys | p.R360K | Q9BZF1 | protein_coding | tolerated(0.97) | benign(0.053) | TCGA-BR-6458-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | |
OSBPL8 | SNV | Missense_Mutation | c.1103C>A | p.Pro368His | p.P368H | Q9BZF1 | protein_coding | tolerated(0.09) | benign(0.416) | TCGA-D7-A4YY-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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