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Gene: NUP188 |
Gene summary for NUP188 |
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Gene information | Species | Human | Gene symbol | NUP188 | Gene ID | 23511 |
Gene name | nucleoporin 188 | |
Gene Alias | KIAA0169 | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0006403 | UniProtAcc | Q5SRE5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23511 | NUP188 | CCI_2 | Human | Cervix | CC | 2.17e-08 | 7.22e-01 | 0.5249 |
23511 | NUP188 | CCI_3 | Human | Cervix | CC | 7.12e-03 | 5.20e-01 | 0.516 |
23511 | NUP188 | C04 | Human | Oral cavity | OSCC | 2.21e-02 | 2.52e-01 | 0.2633 |
23511 | NUP188 | C21 | Human | Oral cavity | OSCC | 1.40e-05 | 2.88e-01 | 0.2678 |
23511 | NUP188 | C30 | Human | Oral cavity | OSCC | 1.32e-31 | 1.12e+00 | 0.3055 |
23511 | NUP188 | C46 | Human | Oral cavity | OSCC | 1.60e-06 | 2.17e-01 | 0.1673 |
23511 | NUP188 | C51 | Human | Oral cavity | OSCC | 1.92e-13 | 6.56e-01 | 0.2674 |
23511 | NUP188 | C57 | Human | Oral cavity | OSCC | 1.80e-03 | 2.17e-01 | 0.1679 |
23511 | NUP188 | LN22 | Human | Oral cavity | OSCC | 3.48e-03 | 5.00e-01 | 0.1733 |
23511 | NUP188 | SYSMH2 | Human | Oral cavity | OSCC | 2.25e-03 | 2.45e-01 | 0.2326 |
23511 | NUP188 | SYSMH3 | Human | Oral cavity | OSCC | 1.20e-10 | 3.68e-01 | 0.2442 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00725949 | Cervix | CC | establishment of protein localization to organelle | 99/2311 | 422/18723 | 1.23e-10 | 2.11e-08 | 99 |
GO:00069139 | Cervix | CC | nucleocytoplasmic transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:00511699 | Cervix | CC | nuclear transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:00345048 | Cervix | CC | protein localization to nucleus | 68/2311 | 290/18723 | 9.91e-08 | 5.25e-06 | 68 |
GO:00170388 | Cervix | CC | protein import | 48/2311 | 206/18723 | 8.62e-06 | 1.98e-04 | 48 |
GO:00511689 | Cervix | CC | nuclear export | 38/2311 | 154/18723 | 1.86e-05 | 3.46e-04 | 38 |
GO:00511707 | Cervix | CC | import into nucleus | 38/2311 | 159/18723 | 3.98e-05 | 6.18e-04 | 38 |
GO:00512368 | Cervix | CC | establishment of RNA localization | 39/2311 | 166/18723 | 4.76e-05 | 7.25e-04 | 39 |
GO:00066067 | Cervix | CC | protein import into nucleus | 37/2311 | 155/18723 | 5.13e-05 | 7.71e-04 | 37 |
GO:00506578 | Cervix | CC | nucleic acid transport | 38/2311 | 163/18723 | 7.06e-05 | 9.85e-04 | 38 |
GO:00506588 | Cervix | CC | RNA transport | 38/2311 | 163/18723 | 7.06e-05 | 9.85e-04 | 38 |
GO:000640310 | Cervix | CC | RNA localization | 43/2311 | 201/18723 | 2.00e-04 | 2.29e-03 | 43 |
GO:00510284 | Cervix | CC | mRNA transport | 31/2311 | 130/18723 | 2.05e-04 | 2.33e-03 | 31 |
GO:00159318 | Cervix | CC | nucleobase-containing compound transport | 43/2311 | 222/18723 | 1.72e-03 | 1.30e-02 | 43 |
GO:00064054 | Cervix | CC | RNA export from nucleus | 19/2311 | 84/18723 | 6.02e-03 | 3.43e-02 | 19 |
GO:007259418 | Oral cavity | OSCC | establishment of protein localization to organelle | 284/7305 | 422/18723 | 1.50e-32 | 1.35e-29 | 284 |
GO:000640318 | Oral cavity | OSCC | RNA localization | 150/7305 | 201/18723 | 6.90e-25 | 1.98e-22 | 150 |
GO:000691317 | Oral cavity | OSCC | nucleocytoplasmic transport | 204/7305 | 301/18723 | 2.65e-24 | 6.98e-22 | 204 |
GO:005116917 | Oral cavity | OSCC | nuclear transport | 204/7305 | 301/18723 | 2.65e-24 | 6.98e-22 | 204 |
GO:003450415 | Oral cavity | OSCC | protein localization to nucleus | 193/7305 | 290/18723 | 1.22e-21 | 2.35e-19 | 193 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501418 | Cervix | CC | Amyotrophic lateral sclerosis | 103/1267 | 364/8465 | 1.79e-11 | 4.47e-10 | 2.64e-10 | 103 |
hsa0501419 | Cervix | CC | Amyotrophic lateral sclerosis | 103/1267 | 364/8465 | 1.79e-11 | 4.47e-10 | 2.64e-10 | 103 |
hsa0501428 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa030136 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa05014112 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa0301311 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUP188 | SNV | Missense_Mutation | novel | c.3509N>T | p.Trp1170Leu | p.W1170L | Q5SRE5 | protein_coding | deleterious(0.02) | probably_damaging(0.979) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
NUP188 | SNV | Missense_Mutation | novel | c.4550N>A | p.Arg1517Gln | p.R1517Q | Q5SRE5 | protein_coding | tolerated(0.08) | benign(0.005) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
NUP188 | insertion | Nonsense_Mutation | novel | c.2942_2943insACAGTGAGGAAC | p.His981delinsGlnGlnTerGlyThr | p.H981delinsQQ*GT | Q5SRE5 | protein_coding | TCGA-D1-A102-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
NUP188 | SNV | Missense_Mutation | c.3785N>T | p.Lys1262Met | p.K1262M | Q5SRE5 | protein_coding | deleterious(0.03) | possibly_damaging(0.635) | TCGA-DD-A4NI-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NUP188 | SNV | Missense_Mutation | c.3898N>A | p.Gly1300Ser | p.G1300S | Q5SRE5 | protein_coding | tolerated(0.25) | probably_damaging(0.998) | TCGA-LG-A6GG-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NUP188 | SNV | Missense_Mutation | c.1579G>T | p.Ala527Ser | p.A527S | Q5SRE5 | protein_coding | tolerated(0.53) | benign(0.415) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NUP188 | SNV | Missense_Mutation | rs148207291 | c.2225C>T | p.Ala742Val | p.A742V | Q5SRE5 | protein_coding | tolerated(0.24) | probably_damaging(0.995) | TCGA-50-5931-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NUP188 | SNV | Missense_Mutation | c.3748C>A | p.Arg1250Ser | p.R1250S | Q5SRE5 | protein_coding | tolerated(0.06) | benign(0.255) | TCGA-55-6975-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
NUP188 | SNV | Missense_Mutation | novel | c.3708N>T | p.Glu1236Asp | p.E1236D | Q5SRE5 | protein_coding | tolerated(0.3) | benign(0.113) | TCGA-55-8508-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NUP188 | SNV | Missense_Mutation | c.894G>T | p.Gln298His | p.Q298H | Q5SRE5 | protein_coding | tolerated(0.07) | benign(0.232) | TCGA-64-1678-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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