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Gene: NELL2 |
Gene summary for NELL2 |
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Gene information | Species | Human | Gene symbol | NELL2 | Gene ID | 4753 |
Gene name | neural EGFL like 2 | |
Gene Alias | NRP2 | |
Cytomap | 12q12 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | B7Z625 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4753 | NELL2 | LZE7T | Human | Esophagus | ESCC | 4.10e-06 | 4.89e-01 | 0.0667 |
4753 | NELL2 | LZE24T | Human | Esophagus | ESCC | 9.40e-14 | 4.22e-01 | 0.0596 |
4753 | NELL2 | P4T-E | Human | Esophagus | ESCC | 3.02e-19 | 6.08e-01 | 0.1323 |
4753 | NELL2 | P5T-E | Human | Esophagus | ESCC | 3.10e-10 | 2.83e-01 | 0.1327 |
4753 | NELL2 | P8T-E | Human | Esophagus | ESCC | 1.18e-20 | 5.94e-01 | 0.0889 |
4753 | NELL2 | P10T-E | Human | Esophagus | ESCC | 2.53e-02 | 9.09e-02 | 0.116 |
4753 | NELL2 | P12T-E | Human | Esophagus | ESCC | 3.40e-04 | 1.71e-01 | 0.1122 |
4753 | NELL2 | P16T-E | Human | Esophagus | ESCC | 1.22e-02 | 9.64e-02 | 0.1153 |
4753 | NELL2 | P20T-E | Human | Esophagus | ESCC | 1.68e-33 | 7.19e-01 | 0.1124 |
4753 | NELL2 | P22T-E | Human | Esophagus | ESCC | 4.20e-16 | 3.33e-01 | 0.1236 |
4753 | NELL2 | P26T-E | Human | Esophagus | ESCC | 2.03e-04 | 2.27e-01 | 0.1276 |
4753 | NELL2 | P27T-E | Human | Esophagus | ESCC | 1.56e-11 | 3.56e-01 | 0.1055 |
4753 | NELL2 | P32T-E | Human | Esophagus | ESCC | 3.36e-10 | 3.01e-01 | 0.1666 |
4753 | NELL2 | P37T-E | Human | Esophagus | ESCC | 1.52e-02 | 4.21e-01 | 0.1371 |
4753 | NELL2 | P39T-E | Human | Esophagus | ESCC | 5.84e-15 | 3.64e-01 | 0.0894 |
4753 | NELL2 | P47T-E | Human | Esophagus | ESCC | 6.42e-09 | 2.49e-01 | 0.1067 |
4753 | NELL2 | P49T-E | Human | Esophagus | ESCC | 1.71e-19 | 2.30e+00 | 0.1768 |
4753 | NELL2 | P52T-E | Human | Esophagus | ESCC | 1.55e-11 | 3.66e-01 | 0.1555 |
4753 | NELL2 | P54T-E | Human | Esophagus | ESCC | 2.78e-14 | 4.11e-01 | 0.0975 |
4753 | NELL2 | P56T-E | Human | Esophagus | ESCC | 4.32e-02 | 2.73e-01 | 0.1613 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NELL2 | SNV | Missense_Mutation | novel | c.867N>C | p.Gln289His | p.Q289H | Q99435 | protein_coding | deleterious(0.03) | probably_damaging(0.916) | TCGA-73-4658-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NELL2 | SNV | Missense_Mutation | novel | c.506G>T | p.Ser169Ile | p.S169I | Q99435 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
NELL2 | SNV | Missense_Mutation | novel | c.164T>A | p.Val55Asp | p.V55D | Q99435 | protein_coding | deleterious_low_confidence(0.01) | benign(0.031) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
NELL2 | SNV | Missense_Mutation | novel | c.2410C>A | p.Arg804Ser | p.R804S | Q99435 | protein_coding | deleterious(0) | probably_damaging(0.944) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
NELL2 | SNV | Missense_Mutation | novel | c.1751C>T | p.Ala584Val | p.A584V | Q99435 | protein_coding | tolerated(0.18) | benign(0.071) | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
NELL2 | SNV | Missense_Mutation | novel | c.391N>A | p.Leu131Met | p.L131M | Q99435 | protein_coding | tolerated(0.07) | probably_damaging(0.961) | TCGA-95-7947-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NELL2 | SNV | Missense_Mutation | novel | c.2471T>A | p.Leu824Gln | p.L824Q | Q99435 | protein_coding | tolerated(0.34) | benign(0.04) | TCGA-99-8032-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NELL2 | SNV | Missense_Mutation | novel | c.265N>C | p.Gly89Arg | p.G89R | Q99435 | protein_coding | tolerated(0.4) | possibly_damaging(0.643) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NELL2 | SNV | Missense_Mutation | novel | c.2249N>T | p.Cys750Phe | p.C750F | Q99435 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-MP-A4T8-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | navelbine | SD |
NELL2 | SNV | Missense_Mutation | c.2544N>T | p.Gln848His | p.Q848H | Q99435 | protein_coding | deleterious(0.01) | probably_damaging(0.976) | TCGA-MP-A4TI-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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