Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MYO5B

Gene summary for MYO5B

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MYO5B

Gene ID

4645

Gene namemyosin VB
Gene AliasDIAR2
Cytomap18q21.1
Gene Typeprotein-coding
GO ID

GO:0003008

UniProtAcc

Q7Z7A5


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
4645MYO5BHTA11_3410_2000001011HumanColorectumAD3.40e-18-6.06e-010.0155
4645MYO5BHTA11_3361_2000001011HumanColorectumAD4.31e-04-4.73e-01-0.1207
4645MYO5BHTA11_8622_2000001021HumanColorectumSER1.17e-02-6.35e-010.0528
4645MYO5BHTA11_7696_3000711011HumanColorectumAD5.21e-03-3.40e-010.0674
4645MYO5BHTA11_99999970781_79442HumanColorectumMSS4.48e-17-5.89e-010.294
4645MYO5BHTA11_99999971662_82457HumanColorectumMSS1.46e-13-5.58e-010.3859
4645MYO5BHTA11_99999974143_84620HumanColorectumMSS1.22e-35-7.09e-010.3005
4645MYO5BF007HumanColorectumFAP1.85e-03-2.57e-010.1176
4645MYO5BA001-C-207HumanColorectumFAP9.71e-03-2.62e-010.1278
4645MYO5BA015-C-203HumanColorectumFAP2.40e-46-6.91e-01-0.1294
4645MYO5BA015-C-204HumanColorectumFAP1.93e-07-3.77e-01-0.0228
4645MYO5BA014-C-040HumanColorectumFAP7.43e-09-6.17e-01-0.1184
4645MYO5BA002-C-201HumanColorectumFAP5.68e-18-3.65e-010.0324
4645MYO5BA002-C-203HumanColorectumFAP6.43e-07-2.90e-010.2786
4645MYO5BA001-C-119HumanColorectumFAP8.37e-11-5.21e-01-0.1557
4645MYO5BA001-C-108HumanColorectumFAP2.16e-27-4.78e-01-0.0272
4645MYO5BA002-C-205HumanColorectumFAP4.56e-30-6.27e-01-0.1236
4645MYO5BA001-C-104HumanColorectumFAP4.34e-05-3.17e-010.0184
4645MYO5BA015-C-005HumanColorectumFAP1.15e-03-3.18e-01-0.0336
4645MYO5BA015-C-006HumanColorectumFAP1.57e-23-6.32e-01-0.0994
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0007015ColorectumADactin filament organization167/3918442/187231.65e-167.94e-14167
GO:0016197ColorectumADendosomal transport90/3918230/187231.88e-101.73e-0890
GO:0051656ColorectumADestablishment of organelle localization131/3918390/187233.00e-092.06e-07131
GO:0051650ColorectumADestablishment of vesicle localization57/3918161/187231.47e-053.15e-0457
GO:0051648ColorectumADvesicle localization59/3918177/187237.83e-051.25e-0359
GO:0030048ColorectumADactin filament-based movement44/3918127/187232.31e-042.99e-0344
GO:0050878ColorectumADregulation of body fluid levels108/3918379/187232.54e-043.20e-03108
GO:0099515ColorectumADactin filament-based transport12/391821/187233.02e-043.62e-0312
GO:0030050ColorectumADvesicle transport along actin filament11/391819/187234.66e-045.15e-0311
GO:0030705ColorectumADcytoskeleton-dependent intracellular transport60/3918195/187237.56e-047.59e-0360
GO:0003014ColorectumADrenal system process35/3918110/187234.85e-033.27e-0235
GO:00070151ColorectumSERactin filament organization134/2897442/187231.39e-155.70e-13134
GO:00516561ColorectumSERestablishment of organelle localization100/2897390/187231.11e-076.79e-06100
GO:00161971ColorectumSERendosomal transport61/2897230/187231.03e-053.35e-0461
GO:00300481ColorectumSERactin filament-based movement38/2897127/187232.80e-057.56e-0438
GO:00995151ColorectumSERactin filament-based transport11/289721/187239.28e-051.98e-0311
GO:00300501ColorectumSERvesicle transport along actin filament10/289719/187231.86e-043.43e-0310
GO:00516501ColorectumSERestablishment of vesicle localization42/2897161/187233.38e-045.35e-0342
GO:00030141ColorectumSERrenal system process30/2897110/187231.05e-031.22e-0230
GO:00508781ColorectumSERregulation of body fluid levels81/2897379/187231.28e-031.43e-0281
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa05130ColorectumADPathogenic Escherichia coli infection79/2092197/84651.05e-061.36e-058.65e-0679
hsa051301ColorectumADPathogenic Escherichia coli infection79/2092197/84651.05e-061.36e-058.65e-0679
hsa051302ColorectumSERPathogenic Escherichia coli infection60/1580197/84653.63e-054.31e-043.13e-0460
hsa051303ColorectumSERPathogenic Escherichia coli infection60/1580197/84653.63e-054.31e-043.13e-0460
hsa051304ColorectumMSSPathogenic Escherichia coli infection73/1875197/84651.10e-061.48e-059.06e-0673
hsa051305ColorectumMSSPathogenic Escherichia coli infection73/1875197/84651.10e-061.48e-059.06e-0673
hsa051308ColorectumFAPPathogenic Escherichia coli infection62/1404197/84651.37e-073.08e-061.87e-0662
hsa051309ColorectumFAPPathogenic Escherichia coli infection62/1404197/84651.37e-073.08e-061.87e-0662
hsa0513010ColorectumCRCPathogenic Escherichia coli infection47/1091197/84651.49e-053.84e-042.60e-0447
hsa0513011ColorectumCRCPathogenic Escherichia coli infection47/1091197/84651.49e-053.84e-042.60e-0447
hsa0513026EndometriumAEHPathogenic Escherichia coli infection50/1197197/84651.72e-051.86e-041.36e-0450
hsa048144EndometriumAEHMotor proteins42/1197193/84652.41e-031.42e-021.04e-0242
hsa05130112EndometriumAEHPathogenic Escherichia coli infection50/1197197/84651.72e-051.86e-041.36e-0450
hsa0481411EndometriumAEHMotor proteins42/1197193/84652.41e-031.42e-021.04e-0242
hsa0513027EndometriumEECPathogenic Escherichia coli infection51/1237197/84651.98e-052.28e-041.70e-0451
hsa048142EndometriumEECMotor proteins42/1237193/84654.43e-032.39e-021.78e-0242
hsa0513036EndometriumEECPathogenic Escherichia coli infection51/1237197/84651.98e-052.28e-041.70e-0451
hsa048143EndometriumEECMotor proteins42/1237193/84654.43e-032.39e-021.78e-0242
hsa05130211EsophagusESCCPathogenic Escherichia coli infection142/4205197/84658.21e-111.06e-095.42e-10142
hsa05130310EsophagusESCCPathogenic Escherichia coli infection142/4205197/84658.21e-111.06e-095.42e-10142
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MYO5BSNVMissense_Mutationnovelc.1601N>Ap.Ser534Asnp.S534NQ9ULV0protein_codingtolerated(0.16)benign(0)TCGA-EO-A22U-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MYO5BSNVMissense_Mutationrs368289471c.1403N>Tp.Ser468Leup.S468LQ9ULV0protein_codingtolerated(1)benign(0)TCGA-EO-A22X-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnspecificCarboplatinComplete Response
MYO5BSNVMissense_Mutationnovelc.3982N>Ap.Glu1328Lysp.E1328KQ9ULV0protein_codingdeleterious(0.01)probably_damaging(0.987)TCGA-EO-A3B0-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
MYO5BSNVMissense_Mutationrs774950157c.3239N>Ap.Arg1080Lysp.R1080KQ9ULV0protein_codingtolerated(0.09)benign(0.056)TCGA-EO-A3B0-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
MYO5BSNVMissense_Mutationnovelc.1077N>Gp.Ser359Argp.S359RQ9ULV0protein_codingtolerated(0.51)benign(0)TCGA-EY-A1GT-01Endometriumuterine corpus endometrioid carcinomaFemale>=65III/IVUnspecificCarboplatinSD
MYO5BSNVMissense_Mutationrs771243169c.2431N>Tp.Arg811Trpp.R811WQ9ULV0protein_codingdeleterious(0)probably_damaging(0.996)TCGA-FI-A2D0-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
MYO5BSNVMissense_Mutationrs121908105c.1966C>Tp.Arg656Cysp.R656CQ9ULV0protein_codingdeleterious(0)probably_damaging(0.99)TCGA-FI-A2D5-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycarboplatinumPD
MYO5BSNVMissense_Mutationrs746376479c.5171N>Ap.Arg1724Glnp.R1724QQ9ULV0protein_codingdeleterious(0.01)probably_damaging(0.97)TCGA-PG-A917-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MYO5BdeletionFrame_Shift_Delnovelc.5327delNp.Leu1776Terp.L1776*Q9ULV0protein_codingTCGA-AX-A2HD-01Endometriumuterine corpus endometrioid carcinomaFemale>=65III/IVUnknownUnknownSD
MYO5BinsertionFrame_Shift_Insnovelc.1546_1547insCTGTGCCTTACGTTGCTTATGTGp.Val516AlafsTer73p.V516Afs*73Q9ULV0protein_codingTCGA-B5-A11V-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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