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Gene: MVP |
Gene summary for MVP |
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Gene information | Species | Human | Gene symbol | MVP | Gene ID | 9961 |
Gene name | major vault protein | |
Gene Alias | LRP | |
Cytomap | 16p11.2 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q14764 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9961 | MVP | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.75e-18 | 1.00e+00 | -0.1808 |
9961 | MVP | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.12e-10 | 7.19e-01 | -0.0811 |
9961 | MVP | HTA11_78_2000001011 | Human | Colorectum | AD | 3.25e-05 | 5.65e-01 | -0.1088 |
9961 | MVP | HTA11_347_2000001011 | Human | Colorectum | AD | 2.19e-24 | 8.62e-01 | -0.1954 |
9961 | MVP | HTA11_411_2000001011 | Human | Colorectum | SER | 2.63e-10 | 1.68e+00 | -0.2602 |
9961 | MVP | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.55e-13 | 1.42e+00 | -0.2196 |
9961 | MVP | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.76e-10 | 7.86e-01 | -0.1207 |
9961 | MVP | HTA11_83_2000001011 | Human | Colorectum | SER | 1.63e-08 | 7.91e-01 | -0.1526 |
9961 | MVP | HTA11_696_2000001011 | Human | Colorectum | AD | 1.67e-33 | 1.12e+00 | -0.1464 |
9961 | MVP | HTA11_866_2000001011 | Human | Colorectum | AD | 4.17e-12 | 6.22e-01 | -0.1001 |
9961 | MVP | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.22e-20 | 1.05e+00 | -0.059 |
9961 | MVP | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.36e-06 | 8.75e-01 | -0.1706 |
9961 | MVP | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.01e-03 | 7.01e-01 | -0.2061 |
9961 | MVP | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.33e-03 | 8.34e-01 | -0.1462 |
9961 | MVP | HTA11_546_2000001011 | Human | Colorectum | AD | 1.88e-05 | 6.84e-01 | -0.0842 |
9961 | MVP | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.00e-02 | 4.10e-01 | 0.0338 |
9961 | MVP | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.43e-02 | 3.23e-01 | 0.0674 |
9961 | MVP | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.93e-11 | 6.51e-01 | 0.3859 |
9961 | MVP | F007 | Human | Colorectum | FAP | 1.89e-04 | -3.42e-01 | 0.1176 |
9961 | MVP | A002-C-010 | Human | Colorectum | FAP | 4.10e-05 | -2.19e-01 | 0.242 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0038127 | Colorectum | AD | ERBB signaling pathway | 55/3918 | 121/18723 | 1.19e-09 | 8.85e-08 | 55 |
GO:0007173 | Colorectum | AD | epidermal growth factor receptor signaling pathway | 50/3918 | 108/18723 | 3.08e-09 | 2.07e-07 | 50 |
GO:0006403 | Colorectum | AD | RNA localization | 71/3918 | 201/18723 | 1.54e-06 | 4.76e-05 | 71 |
GO:1901185 | Colorectum | AD | negative regulation of ERBB signaling pathway | 19/3918 | 32/18723 | 2.39e-06 | 6.98e-05 | 19 |
GO:1901184 | Colorectum | AD | regulation of ERBB signaling pathway | 34/3918 | 79/18723 | 7.46e-06 | 1.82e-04 | 34 |
GO:0010563 | Colorectum | AD | negative regulation of phosphorus metabolic process | 130/3918 | 442/18723 | 1.26e-05 | 2.76e-04 | 130 |
GO:0045936 | Colorectum | AD | negative regulation of phosphate metabolic process | 129/3918 | 441/18723 | 1.81e-05 | 3.76e-04 | 129 |
GO:0051236 | Colorectum | AD | establishment of RNA localization | 58/3918 | 166/18723 | 1.95e-05 | 4.01e-04 | 58 |
GO:0015931 | Colorectum | AD | nucleobase-containing compound transport | 73/3918 | 222/18723 | 2.02e-05 | 4.10e-04 | 73 |
GO:0051348 | Colorectum | AD | negative regulation of transferase activity | 85/3918 | 268/18723 | 2.07e-05 | 4.19e-04 | 85 |
GO:0050657 | Colorectum | AD | nucleic acid transport | 57/3918 | 163/18723 | 2.22e-05 | 4.39e-04 | 57 |
GO:0050658 | Colorectum | AD | RNA transport | 57/3918 | 163/18723 | 2.22e-05 | 4.39e-04 | 57 |
GO:0046777 | Colorectum | AD | protein autophosphorylation | 74/3918 | 227/18723 | 2.48e-05 | 4.76e-04 | 74 |
GO:0042058 | Colorectum | AD | regulation of epidermal growth factor receptor signaling pathway | 31/3918 | 73/18723 | 2.56e-05 | 4.89e-04 | 31 |
GO:0042059 | Colorectum | AD | negative regulation of epidermal growth factor receptor signaling pathway | 16/3918 | 28/18723 | 2.96e-05 | 5.46e-04 | 16 |
GO:0042326 | Colorectum | AD | negative regulation of phosphorylation | 112/3918 | 385/18723 | 8.02e-05 | 1.27e-03 | 112 |
GO:0001933 | Colorectum | AD | negative regulation of protein phosphorylation | 101/3918 | 342/18723 | 9.39e-05 | 1.42e-03 | 101 |
GO:0006469 | Colorectum | AD | negative regulation of protein kinase activity | 65/3918 | 212/18723 | 5.21e-04 | 5.62e-03 | 65 |
GO:0033673 | Colorectum | AD | negative regulation of kinase activity | 71/3918 | 237/18723 | 6.18e-04 | 6.47e-03 | 71 |
GO:0051028 | Colorectum | AD | mRNA transport | 42/3918 | 130/18723 | 1.57e-03 | 1.32e-02 | 42 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MVP | SNV | Missense_Mutation | c.847N>T | p.Val283Leu | p.V283L | Q14764 | protein_coding | tolerated(0.05) | possibly_damaging(0.648) | TCGA-CR-7377-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MVP | insertion | In_Frame_Ins | novel | c.368_369insGGTATTTTTGTGGTTACC | p.Leu123_Lys124insValPheLeuTrpLeuPro | p.L123_K124insVFLWLP | Q14764 | protein_coding | TCGA-CR-6474-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unspecific | PD | |||
MVP | SNV | Missense_Mutation | rs560872333 | c.146N>A | p.Arg49His | p.R49H | Q14764 | protein_coding | tolerated(0.12) | benign(0.025) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
MVP | SNV | Missense_Mutation | novel | c.691N>A | p.Ala231Thr | p.A231T | Q14764 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
MVP | SNV | Missense_Mutation | rs753938190 | c.523N>T | p.Arg175Trp | p.R175W | Q14764 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MVP | SNV | Missense_Mutation | novel | c.1495N>C | p.Ser499Pro | p.S499P | Q14764 | protein_coding | deleterious(0) | possibly_damaging(0.779) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
MVP | SNV | Missense_Mutation | c.2365N>A | p.Glu789Lys | p.E789K | Q14764 | protein_coding | tolerated(0.11) | benign(0.024) | TCGA-EQ-8122-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
MVP | SNV | Missense_Mutation | rs754161146 | c.256N>A | p.Ala86Thr | p.A86T | Q14764 | protein_coding | deleterious(0) | possibly_damaging(0.71) | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
MVP | SNV | Missense_Mutation | rs755247776 | c.608N>T | p.Ala203Val | p.A203V | Q14764 | protein_coding | tolerated(0.06) | probably_damaging(1) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MVP | SNV | Missense_Mutation | c.1341N>T | p.Gln447His | p.Q447H | Q14764 | protein_coding | tolerated(0.09) | benign(0.235) | TCGA-HU-A4H4-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | ts-1 | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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