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Gene: MIOS |
Gene summary for MIOS |
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Gene information | Species | Human | Gene symbol | MIOS | Gene ID | 54468 |
Gene name | meiosis regulator for oocyte development | |
Gene Alias | MIO | |
Cytomap | 7p21.3 | |
Gene Type | protein-coding | GO ID | GO:0006950 | UniProtAcc | A0A024RA24 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54468 | MIOS | LZE4T | Human | Esophagus | ESCC | 3.52e-06 | 1.75e-01 | 0.0811 |
54468 | MIOS | LZE24T | Human | Esophagus | ESCC | 1.92e-09 | 2.09e-01 | 0.0596 |
54468 | MIOS | LZE21T | Human | Esophagus | ESCC | 2.13e-02 | 1.30e-01 | 0.0655 |
54468 | MIOS | P2T-E | Human | Esophagus | ESCC | 8.88e-23 | 3.08e-01 | 0.1177 |
54468 | MIOS | P4T-E | Human | Esophagus | ESCC | 2.93e-11 | 1.97e-01 | 0.1323 |
54468 | MIOS | P5T-E | Human | Esophagus | ESCC | 8.31e-04 | 1.21e-01 | 0.1327 |
54468 | MIOS | P8T-E | Human | Esophagus | ESCC | 2.50e-09 | 1.48e-01 | 0.0889 |
54468 | MIOS | P9T-E | Human | Esophagus | ESCC | 1.39e-05 | 7.29e-02 | 0.1131 |
54468 | MIOS | P10T-E | Human | Esophagus | ESCC | 4.93e-07 | 1.66e-01 | 0.116 |
54468 | MIOS | P11T-E | Human | Esophagus | ESCC | 2.91e-13 | 3.90e-01 | 0.1426 |
54468 | MIOS | P12T-E | Human | Esophagus | ESCC | 1.56e-22 | 2.44e-01 | 0.1122 |
54468 | MIOS | P15T-E | Human | Esophagus | ESCC | 7.57e-11 | 1.98e-01 | 0.1149 |
54468 | MIOS | P16T-E | Human | Esophagus | ESCC | 3.06e-18 | 1.79e-01 | 0.1153 |
54468 | MIOS | P17T-E | Human | Esophagus | ESCC | 4.35e-02 | 1.14e-01 | 0.1278 |
54468 | MIOS | P20T-E | Human | Esophagus | ESCC | 1.50e-05 | 1.50e-01 | 0.1124 |
54468 | MIOS | P21T-E | Human | Esophagus | ESCC | 6.64e-13 | 1.45e-01 | 0.1617 |
54468 | MIOS | P22T-E | Human | Esophagus | ESCC | 7.00e-18 | 1.46e-01 | 0.1236 |
54468 | MIOS | P23T-E | Human | Esophagus | ESCC | 4.81e-16 | 1.45e-01 | 0.108 |
54468 | MIOS | P24T-E | Human | Esophagus | ESCC | 3.14e-08 | 9.95e-02 | 0.1287 |
54468 | MIOS | P26T-E | Human | Esophagus | ESCC | 5.68e-12 | 2.73e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0071496111 | Esophagus | ESCC | cellular response to external stimulus | 215/8552 | 320/18723 | 4.29e-15 | 2.43e-13 | 215 |
GO:0031668111 | Esophagus | ESCC | cellular response to extracellular stimulus | 168/8552 | 246/18723 | 4.93e-13 | 2.23e-11 | 168 |
GO:0031669110 | Esophagus | ESCC | cellular response to nutrient levels | 148/8552 | 215/18723 | 4.58e-12 | 1.76e-10 | 148 |
GO:0031667111 | Esophagus | ESCC | response to nutrient levels | 289/8552 | 474/18723 | 9.25e-12 | 3.47e-10 | 289 |
GO:0009267110 | Esophagus | ESCC | cellular response to starvation | 110/8552 | 156/18723 | 2.63e-10 | 7.37e-09 | 110 |
GO:004259419 | Esophagus | ESCC | response to starvation | 133/8552 | 197/18723 | 4.31e-10 | 1.14e-08 | 133 |
GO:003150314 | Esophagus | ESCC | protein-containing complex localization | 139/8552 | 220/18723 | 1.14e-07 | 1.85e-06 | 139 |
GO:19909284 | Esophagus | ESCC | response to amino acid starvation | 37/8552 | 49/18723 | 2.05e-05 | 1.78e-04 | 37 |
GO:00319294 | Esophagus | ESCC | TOR signaling | 79/8552 | 126/18723 | 8.57e-05 | 6.21e-04 | 79 |
GO:00341984 | Esophagus | ESCC | cellular response to amino acid starvation | 34/8552 | 46/18723 | 9.39e-05 | 6.70e-04 | 34 |
GO:00320061 | Esophagus | ESCC | regulation of TOR signaling | 63/8552 | 104/18723 | 1.55e-03 | 7.29e-03 | 63 |
GO:00320082 | Esophagus | ESCC | positive regulation of TOR signaling | 31/8552 | 47/18723 | 4.01e-03 | 1.62e-02 | 31 |
GO:00316677 | Liver | NAFLD | response to nutrient levels | 85/1882 | 474/18723 | 8.23e-08 | 7.09e-06 | 85 |
GO:00714967 | Liver | NAFLD | cellular response to external stimulus | 51/1882 | 320/18723 | 6.21e-04 | 8.18e-03 | 51 |
GO:00425945 | Liver | NAFLD | response to starvation | 33/1882 | 197/18723 | 2.35e-03 | 2.21e-02 | 33 |
GO:003166722 | Liver | HCC | response to nutrient levels | 276/7958 | 474/18723 | 2.30e-12 | 1.08e-10 | 276 |
GO:007149622 | Liver | HCC | cellular response to external stimulus | 191/7958 | 320/18723 | 3.40e-10 | 1.13e-08 | 191 |
GO:003166812 | Liver | HCC | cellular response to extracellular stimulus | 149/7958 | 246/18723 | 7.35e-09 | 1.86e-07 | 149 |
GO:004259421 | Liver | HCC | response to starvation | 121/7958 | 197/18723 | 6.08e-08 | 1.28e-06 | 121 |
GO:003166912 | Liver | HCC | cellular response to nutrient levels | 130/7958 | 215/18723 | 7.52e-08 | 1.51e-06 | 130 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041505 | Esophagus | ESCC | mTOR signaling pathway | 98/4205 | 156/8465 | 5.81e-04 | 1.95e-03 | 9.97e-04 | 98 |
hsa0415013 | Esophagus | ESCC | mTOR signaling pathway | 98/4205 | 156/8465 | 5.81e-04 | 1.95e-03 | 9.97e-04 | 98 |
hsa041502 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
hsa0415011 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MIOS | SNV | Missense_Mutation | novel | c.268A>T | p.Thr90Ser | p.T90S | Q9NXC5 | protein_coding | tolerated(0.32) | benign(0.019) | TCGA-92-7341-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MIOS | SNV | Missense_Mutation | novel | c.8N>T | p.Gly3Val | p.G3V | Q9NXC5 | protein_coding | tolerated(0.1) | probably_damaging(0.949) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MIOS | deletion | Frame_Shift_Del | c.752delN | p.Asp252IlefsTer10 | p.D252Ifs*10 | Q9NXC5 | protein_coding | TCGA-35-4122-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
MIOS | SNV | Missense_Mutation | novel | c.1262N>T | p.Pro421Leu | p.P421L | Q9NXC5 | protein_coding | tolerated(0.05) | benign(0.012) | TCGA-CV-7177-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MIOS | SNV | Missense_Mutation | c.2336N>A | p.Arg779Gln | p.R779Q | Q9NXC5 | protein_coding | deleterious(0) | possibly_damaging(0.892) | TCGA-CV-7435-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MIOS | SNV | Missense_Mutation | novel | c.368N>T | p.Pro123Leu | p.P123L | Q9NXC5 | protein_coding | deleterious(0) | benign(0.382) | TCGA-CV-A468-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MIOS | SNV | Missense_Mutation | novel | c.2354G>A | p.Cys785Tyr | p.C785Y | Q9NXC5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DQ-5629-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD |
MIOS | SNV | Missense_Mutation | rs761486524 | c.1216N>G | p.Thr406Ala | p.T406A | Q9NXC5 | protein_coding | tolerated(0.75) | benign(0.031) | TCGA-KK-A6E2-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
MIOS | SNV | Missense_Mutation | novel | c.2296N>A | p.Ser766Thr | p.S766T | Q9NXC5 | protein_coding | tolerated(0.76) | benign(0.039) | TCGA-V1-A9OQ-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 6 | Unknown | Unknown | SD |
MIOS | SNV | Missense_Mutation | rs370610296 | c.1664A>G | p.Asn555Ser | p.N555S | Q9NXC5 | protein_coding | tolerated(0.11) | benign(0.153) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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