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Gene: MAGEC2 |
Gene summary for MAGEC2 |
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Gene information | Species | Human | Gene symbol | MAGEC2 | Gene ID | 51438 |
Gene name | MAGE family member C2 | |
Gene Alias | CT10 | |
Cytomap | Xq27.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9UBF1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51438 | MAGEC2 | S014 | Human | Liver | HCC | 1.72e-35 | 1.39e+00 | 0.2254 |
51438 | MAGEC2 | S015 | Human | Liver | HCC | 7.02e-42 | 1.71e+00 | 0.2375 |
51438 | MAGEC2 | S016 | Human | Liver | HCC | 3.86e-45 | 1.49e+00 | 0.2243 |
51438 | MAGEC2 | S028 | Human | Liver | HCC | 3.51e-22 | 6.86e-01 | 0.2503 |
51438 | MAGEC2 | S029 | Human | Liver | HCC | 7.94e-23 | 7.21e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190332022 | Liver | HCC | regulation of protein modification by small protein conjugation or removal | 167/7958 | 242/18723 | 4.99e-17 | 4.72e-15 | 167 |
GO:003139622 | Liver | HCC | regulation of protein ubiquitination | 142/7958 | 210/18723 | 1.39e-13 | 7.81e-12 | 142 |
GO:19033221 | Liver | HCC | positive regulation of protein modification by small protein conjugation or removal | 94/7958 | 138/18723 | 9.87e-10 | 3.01e-08 | 94 |
GO:00313981 | Liver | HCC | positive regulation of protein ubiquitination | 79/7958 | 119/18723 | 1.18e-07 | 2.26e-06 | 79 |
GO:005143821 | Liver | HCC | regulation of ubiquitin-protein transferase activity | 36/7958 | 53/18723 | 1.62e-04 | 1.29e-03 | 36 |
GO:0051443 | Liver | HCC | positive regulation of ubiquitin-protein transferase activity | 21/7958 | 31/18723 | 4.01e-03 | 1.76e-02 | 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAGEC2 | SNV | Missense_Mutation | c.193G>C | p.Gly65Arg | p.G65R | Q9UBF1 | protein_coding | tolerated(0.22) | probably_damaging(0.931) | TCGA-66-2787-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MAGEC2 | SNV | Missense_Mutation | novel | c.422N>C | p.Leu141Pro | p.L141P | Q9UBF1 | protein_coding | deleterious(0) | benign(0.445) | TCGA-77-7139-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MAGEC2 | SNV | Missense_Mutation | c.316N>A | p.Ser106Thr | p.S106T | Q9UBF1 | protein_coding | tolerated(0.44) | possibly_damaging(0.874) | TCGA-77-7141-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MAGEC2 | SNV | Missense_Mutation | novel | c.166N>C | p.Ser56Pro | p.S56P | Q9UBF1 | protein_coding | tolerated(0.21) | benign(0) | TCGA-85-7710-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAGEC2 | SNV | Missense_Mutation | novel | c.17G>T | p.Gly6Val | p.G6V | Q9UBF1 | protein_coding | tolerated_low_confidence(0.05) | benign(0.13) | TCGA-85-8070-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MAGEC2 | SNV | Missense_Mutation | novel | c.102G>T | p.Glu34Asp | p.E34D | Q9UBF1 | protein_coding | tolerated(0.14) | benign(0.286) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MAGEC2 | SNV | Missense_Mutation | novel | c.274N>G | p.Pro92Ala | p.P92A | Q9UBF1 | protein_coding | tolerated(0.26) | benign(0.154) | TCGA-96-7544-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MAGEC2 | SNV | Missense_Mutation | novel | c.661N>A | p.Asp221Asn | p.D221N | Q9UBF1 | protein_coding | tolerated(0.24) | benign(0.408) | TCGA-NC-A5HK-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MAGEC2 | SNV | Missense_Mutation | novel | c.728N>A | p.Cys243Tyr | p.C243Y | Q9UBF1 | protein_coding | tolerated(0.22) | benign(0.191) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
MAGEC2 | SNV | Missense_Mutation | c.617N>T | p.Cys206Phe | p.C206F | Q9UBF1 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-O2-A5IB-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
51438 | MAGEC2 | ENZYME | CV-9201 |
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