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Gene: LRRC8D |
Gene summary for LRRC8D |
Gene summary. |
Gene information | Species | Human | Gene symbol | LRRC8D | Gene ID | 55144 |
Gene name | leucine rich repeat containing 8 VRAC subunit D | |
Gene Alias | HsLRRC8D | |
Cytomap | 1p22.2 | |
Gene Type | protein-coding | GO ID | GO:0001678 | UniProtAcc | B3KRU1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55144 | LRRC8D | LZE4T | Human | Esophagus | ESCC | 1.33e-02 | 7.31e-02 | 0.0811 |
55144 | LRRC8D | LZE7T | Human | Esophagus | ESCC | 1.72e-06 | 1.80e-01 | 0.0667 |
55144 | LRRC8D | LZE24T | Human | Esophagus | ESCC | 7.06e-10 | 9.52e-02 | 0.0596 |
55144 | LRRC8D | P2T-E | Human | Esophagus | ESCC | 4.74e-17 | 2.74e-01 | 0.1177 |
55144 | LRRC8D | P4T-E | Human | Esophagus | ESCC | 7.90e-11 | 3.06e-01 | 0.1323 |
55144 | LRRC8D | P5T-E | Human | Esophagus | ESCC | 1.86e-09 | 1.00e-01 | 0.1327 |
55144 | LRRC8D | P8T-E | Human | Esophagus | ESCC | 1.54e-08 | 1.59e-01 | 0.0889 |
55144 | LRRC8D | P9T-E | Human | Esophagus | ESCC | 1.80e-05 | 1.27e-01 | 0.1131 |
55144 | LRRC8D | P10T-E | Human | Esophagus | ESCC | 2.58e-30 | 3.23e-01 | 0.116 |
55144 | LRRC8D | P11T-E | Human | Esophagus | ESCC | 1.98e-02 | 3.46e-01 | 0.1426 |
55144 | LRRC8D | P12T-E | Human | Esophagus | ESCC | 9.67e-77 | 1.58e+00 | 0.1122 |
55144 | LRRC8D | P15T-E | Human | Esophagus | ESCC | 3.29e-13 | 3.07e-01 | 0.1149 |
55144 | LRRC8D | P16T-E | Human | Esophagus | ESCC | 6.56e-18 | 4.00e-01 | 0.1153 |
55144 | LRRC8D | P17T-E | Human | Esophagus | ESCC | 3.87e-02 | 2.01e-01 | 0.1278 |
55144 | LRRC8D | P20T-E | Human | Esophagus | ESCC | 5.46e-14 | 2.11e-01 | 0.1124 |
55144 | LRRC8D | P21T-E | Human | Esophagus | ESCC | 1.58e-22 | 5.75e-01 | 0.1617 |
55144 | LRRC8D | P22T-E | Human | Esophagus | ESCC | 8.02e-10 | 1.49e-01 | 0.1236 |
55144 | LRRC8D | P23T-E | Human | Esophagus | ESCC | 1.82e-14 | 3.32e-01 | 0.108 |
55144 | LRRC8D | P24T-E | Human | Esophagus | ESCC | 2.32e-06 | 4.41e-02 | 0.1287 |
55144 | LRRC8D | P26T-E | Human | Esophagus | ESCC | 8.12e-33 | 6.15e-01 | 0.1276 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:007121419 | Esophagus | ESCC | cellular response to abiotic stimulus | 206/8552 | 331/18723 | 7.52e-10 | 1.88e-08 | 206 |
GO:010400419 | Esophagus | ESCC | cellular response to environmental stimulus | 206/8552 | 331/18723 | 7.52e-10 | 1.88e-08 | 206 |
GO:00069707 | Esophagus | ESCC | response to osmotic stress | 57/8552 | 84/18723 | 3.26e-05 | 2.70e-04 | 57 |
GO:00714707 | Esophagus | ESCC | cellular response to osmotic stress | 31/8552 | 41/18723 | 9.32e-05 | 6.68e-04 | 31 |
GO:00512592 | Esophagus | ESCC | protein complex oligomerization | 130/8552 | 238/18723 | 3.29e-03 | 1.36e-02 | 130 |
GO:006219722 | Liver | HCC | cellular response to chemical stress | 216/7958 | 337/18723 | 6.86e-16 | 5.44e-14 | 216 |
GO:007121421 | Liver | HCC | cellular response to abiotic stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:010400421 | Liver | HCC | cellular response to environmental stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:00069702 | Liver | HCC | response to osmotic stress | 52/7958 | 84/18723 | 2.58e-04 | 1.92e-03 | 52 |
GO:004259322 | Liver | HCC | glucose homeostasis | 137/7958 | 258/18723 | 3.59e-04 | 2.49e-03 | 137 |
GO:003350022 | Liver | HCC | carbohydrate homeostasis | 137/7958 | 259/18723 | 4.45e-04 | 2.98e-03 | 137 |
GO:000167822 | Liver | HCC | cellular glucose homeostasis | 95/7958 | 172/18723 | 4.95e-04 | 3.24e-03 | 95 |
GO:00714701 | Liver | HCC | cellular response to osmotic stress | 28/7958 | 41/18723 | 7.54e-04 | 4.55e-03 | 28 |
GO:006219720 | Oral cavity | OSCC | cellular response to chemical stress | 204/7305 | 337/18723 | 6.89e-16 | 5.19e-14 | 204 |
GO:007121416 | Oral cavity | OSCC | cellular response to abiotic stimulus | 186/7305 | 331/18723 | 1.38e-10 | 4.10e-09 | 186 |
GO:010400416 | Oral cavity | OSCC | cellular response to environmental stimulus | 186/7305 | 331/18723 | 1.38e-10 | 4.10e-09 | 186 |
GO:00069706 | Oral cavity | OSCC | response to osmotic stress | 50/7305 | 84/18723 | 1.11e-04 | 8.15e-04 | 50 |
GO:0051259 | Oral cavity | OSCC | protein complex oligomerization | 121/7305 | 238/18723 | 1.29e-04 | 9.21e-04 | 121 |
GO:000167816 | Oral cavity | OSCC | cellular glucose homeostasis | 88/7305 | 172/18723 | 7.74e-04 | 4.22e-03 | 88 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRRC8D | insertion | Frame_Shift_Ins | novel | c.2079_2080insA | p.Ile695AsnfsTer21 | p.I695Nfs*21 | Q7L1W4 | protein_coding | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
LRRC8D | insertion | Frame_Shift_Ins | novel | c.1714_1715insGAAATCTTAGCAGGAATTTT | p.Asn572ArgfsTer14 | p.N572Rfs*14 | Q7L1W4 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
LRRC8D | insertion | Frame_Shift_Ins | novel | c.1321_1322insC | p.Val441AlafsTer2 | p.V441Afs*2 | Q7L1W4 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
LRRC8D | insertion | Frame_Shift_Ins | novel | c.1322_1323insTTTTCAACATG | p.Ser442PhefsTer14 | p.S442Ffs*14 | Q7L1W4 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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