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Gene: LRIG2 |
Gene summary for LRIG2 |
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Gene information | Species | Human | Gene symbol | LRIG2 | Gene ID | 9860 |
Gene name | leucine rich repeats and immunoglobulin like domains 2 | |
Gene Alias | LIG-2 | |
Cytomap | 1p13.2 | |
Gene Type | protein-coding | GO ID | GO:0001764 | UniProtAcc | O94898 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9860 | LRIG2 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.61e-03 | -2.46e-02 | -0.1869 |
9860 | LRIG2 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 4.25e-03 | -3.95e-02 | -0.1883 |
9860 | LRIG2 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 5.65e-03 | -8.51e-02 | -0.1917 |
9860 | LRIG2 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 3.44e-04 | -6.51e-02 | -0.1916 |
9860 | LRIG2 | LZE4T | Human | Esophagus | ESCC | 3.63e-04 | 1.32e-01 | 0.0811 |
9860 | LRIG2 | P2T-E | Human | Esophagus | ESCC | 4.02e-10 | 1.96e-01 | 0.1177 |
9860 | LRIG2 | P4T-E | Human | Esophagus | ESCC | 4.85e-03 | 9.87e-02 | 0.1323 |
9860 | LRIG2 | P5T-E | Human | Esophagus | ESCC | 7.70e-08 | 6.63e-02 | 0.1327 |
9860 | LRIG2 | P8T-E | Human | Esophagus | ESCC | 7.53e-09 | 1.27e-01 | 0.0889 |
9860 | LRIG2 | P9T-E | Human | Esophagus | ESCC | 4.98e-02 | 8.43e-02 | 0.1131 |
9860 | LRIG2 | P10T-E | Human | Esophagus | ESCC | 3.17e-35 | 5.09e-01 | 0.116 |
9860 | LRIG2 | P11T-E | Human | Esophagus | ESCC | 1.16e-03 | 1.77e-01 | 0.1426 |
9860 | LRIG2 | P12T-E | Human | Esophagus | ESCC | 7.87e-49 | 7.23e-01 | 0.1122 |
9860 | LRIG2 | P15T-E | Human | Esophagus | ESCC | 6.76e-06 | 1.67e-01 | 0.1149 |
9860 | LRIG2 | P16T-E | Human | Esophagus | ESCC | 1.16e-08 | 9.19e-02 | 0.1153 |
9860 | LRIG2 | P20T-E | Human | Esophagus | ESCC | 4.82e-04 | 1.22e-01 | 0.1124 |
9860 | LRIG2 | P21T-E | Human | Esophagus | ESCC | 1.06e-04 | 3.91e-02 | 0.1617 |
9860 | LRIG2 | P22T-E | Human | Esophagus | ESCC | 1.97e-13 | 1.63e-01 | 0.1236 |
9860 | LRIG2 | P23T-E | Human | Esophagus | ESCC | 3.42e-03 | 1.33e-01 | 0.108 |
9860 | LRIG2 | P26T-E | Human | Esophagus | ESCC | 1.10e-05 | 8.70e-02 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004217617 | Endometrium | EEC | regulation of protein catabolic process | 103/2168 | 391/18723 | 3.54e-16 | 1.52e-13 | 103 |
GO:190382917 | Endometrium | EEC | positive regulation of cellular protein localization | 67/2168 | 276/18723 | 2.27e-09 | 1.84e-07 | 67 |
GO:006156412 | Endometrium | EEC | axon development | 93/2168 | 467/18723 | 9.60e-08 | 4.69e-06 | 93 |
GO:004217716 | Endometrium | EEC | negative regulation of protein catabolic process | 35/2168 | 121/18723 | 1.79e-07 | 8.20e-06 | 35 |
GO:004586117 | Endometrium | EEC | negative regulation of proteolysis | 72/2168 | 351/18723 | 8.46e-07 | 2.98e-05 | 72 |
GO:003109914 | Endometrium | EEC | regeneration | 45/2168 | 198/18723 | 6.19e-06 | 1.49e-04 | 45 |
GO:003133017 | Endometrium | EEC | negative regulation of cellular catabolic process | 55/2168 | 262/18723 | 7.93e-06 | 1.80e-04 | 55 |
GO:000989516 | Endometrium | EEC | negative regulation of catabolic process | 61/2168 | 320/18723 | 5.76e-05 | 8.97e-04 | 61 |
GO:001097513 | Endometrium | EEC | regulation of neuron projection development | 79/2168 | 445/18723 | 6.80e-05 | 1.01e-03 | 79 |
GO:190303415 | Endometrium | EEC | regulation of response to wounding | 36/2168 | 167/18723 | 1.58e-04 | 1.99e-03 | 36 |
GO:00017641 | Endometrium | EEC | neuron migration | 33/2168 | 156/18723 | 4.17e-04 | 4.38e-03 | 33 |
GO:0031102 | Endometrium | EEC | neuron projection regeneration | 15/2168 | 60/18723 | 2.88e-03 | 2.03e-02 | 15 |
GO:00311031 | Endometrium | EEC | axon regeneration | 13/2168 | 52/18723 | 5.34e-03 | 3.31e-02 | 13 |
GO:00486783 | Endometrium | EEC | response to axon injury | 18/2168 | 83/18723 | 6.04e-03 | 3.57e-02 | 18 |
GO:0042176111 | Esophagus | ESCC | regulation of protein catabolic process | 280/8552 | 391/18723 | 8.65e-26 | 2.39e-23 | 280 |
GO:1903829111 | Esophagus | ESCC | positive regulation of cellular protein localization | 199/8552 | 276/18723 | 2.99e-19 | 3.45e-17 | 199 |
GO:0009895111 | Esophagus | ESCC | negative regulation of catabolic process | 201/8552 | 320/18723 | 3.88e-10 | 1.05e-08 | 201 |
GO:0031330111 | Esophagus | ESCC | negative regulation of cellular catabolic process | 166/8552 | 262/18723 | 5.17e-09 | 1.08e-07 | 166 |
GO:0042177111 | Esophagus | ESCC | negative regulation of protein catabolic process | 84/8552 | 121/18723 | 1.03e-07 | 1.69e-06 | 84 |
GO:003109910 | Esophagus | ESCC | regeneration | 122/8552 | 198/18723 | 4.26e-06 | 4.57e-05 | 122 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0436022 | Endometrium | EEC | Axon guidance | 39/1237 | 182/8465 | 7.78e-03 | 3.66e-02 | 2.73e-02 | 39 |
hsa0436032 | Endometrium | EEC | Axon guidance | 39/1237 | 182/8465 | 7.78e-03 | 3.66e-02 | 2.73e-02 | 39 |
hsa0436016 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0436017 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRIG2 | SNV | Missense_Mutation | novel | c.1645N>T | p.Val549Phe | p.V549F | O94898 | protein_coding | deleterious(0.02) | possibly_damaging(0.516) | TCGA-P3-A6T6-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cetuximab | PD |
LRIG2 | SNV | Missense_Mutation | novel | c.898N>C | p.Glu300Gln | p.E300Q | O94898 | protein_coding | tolerated(0.06) | benign(0.011) | TCGA-T3-A92M-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
LRIG2 | SNV | Missense_Mutation | rs371835362 | c.2582N>T | p.Thr861Met | p.T861M | O94898 | protein_coding | deleterious(0.03) | probably_damaging(0.991) | TCGA-J4-A6M7-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
LRIG2 | SNV | Missense_Mutation | novel | c.986N>T | p.Ser329Phe | p.S329F | O94898 | protein_coding | tolerated(0.24) | benign(0.021) | TCGA-X4-A8KQ-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Hormone Therapy | eligard | SD |
LRIG2 | SNV | Missense_Mutation | rs374982078 | c.2989N>A | p.Val997Met | p.V997M | O94898 | protein_coding | deleterious(0.02) | benign(0.031) | TCGA-BR-4257-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LRIG2 | SNV | Missense_Mutation | c.1750N>G | p.Asn584Asp | p.N584D | O94898 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
LRIG2 | SNV | Missense_Mutation | rs368559211 | c.2138N>T | p.Ala713Val | p.A713V | O94898 | protein_coding | tolerated(0.67) | benign(0.131) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
LRIG2 | SNV | Missense_Mutation | novel | c.262N>C | p.Ser88Pro | p.S88P | O94898 | protein_coding | tolerated(0.08) | benign(0.005) | TCGA-BR-7704-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LRIG2 | SNV | Missense_Mutation | c.1911N>T | p.Lys637Asn | p.K637N | O94898 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CD-5801-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
LRIG2 | SNV | Missense_Mutation | rs139029257 | c.2984N>A | p.Arg995Gln | p.R995Q | O94898 | protein_coding | tolerated(0.22) | benign(0.03) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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