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Gene: LGR6 |
Gene summary for LGR6 |
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Gene information | Species | Human | Gene symbol | LGR6 | Gene ID | 59352 |
Gene name | leucine rich repeat containing G protein-coupled receptor 6 | |
Gene Alias | GPCR | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9HBX8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
59352 | LGR6 | P2T-E | Human | Esophagus | ESCC | 3.42e-12 | 5.05e-01 | 0.1177 |
59352 | LGR6 | P4T-E | Human | Esophagus | ESCC | 1.05e-06 | 3.65e-01 | 0.1323 |
59352 | LGR6 | P8T-E | Human | Esophagus | ESCC | 4.48e-04 | 1.15e-01 | 0.0889 |
59352 | LGR6 | P9T-E | Human | Esophagus | ESCC | 4.56e-05 | 1.34e-02 | 0.1131 |
59352 | LGR6 | P10T-E | Human | Esophagus | ESCC | 2.08e-45 | 9.68e-01 | 0.116 |
59352 | LGR6 | P11T-E | Human | Esophagus | ESCC | 4.73e-02 | 1.41e-01 | 0.1426 |
59352 | LGR6 | P12T-E | Human | Esophagus | ESCC | 4.66e-03 | 1.99e-01 | 0.1122 |
59352 | LGR6 | P15T-E | Human | Esophagus | ESCC | 6.58e-09 | 4.55e-01 | 0.1149 |
59352 | LGR6 | P16T-E | Human | Esophagus | ESCC | 3.32e-69 | 2.20e+00 | 0.1153 |
59352 | LGR6 | P21T-E | Human | Esophagus | ESCC | 7.14e-03 | 2.08e-01 | 0.1617 |
59352 | LGR6 | P27T-E | Human | Esophagus | ESCC | 3.12e-11 | 2.69e-01 | 0.1055 |
59352 | LGR6 | P28T-E | Human | Esophagus | ESCC | 1.46e-06 | 1.00e-01 | 0.1149 |
59352 | LGR6 | P30T-E | Human | Esophagus | ESCC | 4.21e-14 | 7.95e-01 | 0.137 |
59352 | LGR6 | P31T-E | Human | Esophagus | ESCC | 3.49e-04 | 1.66e-01 | 0.1251 |
59352 | LGR6 | P56T-E | Human | Esophagus | ESCC | 6.32e-12 | 2.89e+00 | 0.1613 |
59352 | LGR6 | P57T-E | Human | Esophagus | ESCC | 1.79e-05 | 3.96e-01 | 0.0926 |
59352 | LGR6 | P62T-E | Human | Esophagus | ESCC | 3.11e-06 | 1.76e-01 | 0.1302 |
59352 | LGR6 | P65T-E | Human | Esophagus | ESCC | 1.27e-06 | 2.02e-01 | 0.0978 |
59352 | LGR6 | P107T-E | Human | Esophagus | ESCC | 3.82e-02 | 3.65e-02 | 0.171 |
59352 | LGR6 | P127T-E | Human | Esophagus | ESCC | 5.47e-04 | 1.80e-02 | 0.0826 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:003011117 | Esophagus | ESCC | regulation of Wnt signaling pathway | 194/8552 | 328/18723 | 5.39e-07 | 7.14e-06 | 194 |
GO:006007016 | Esophagus | ESCC | canonical Wnt signaling pathway | 180/8552 | 303/18723 | 9.15e-07 | 1.17e-05 | 180 |
GO:006082817 | Esophagus | ESCC | regulation of canonical Wnt signaling pathway | 153/8552 | 253/18723 | 1.38e-06 | 1.67e-05 | 153 |
GO:003109910 | Esophagus | ESCC | regeneration | 122/8552 | 198/18723 | 4.26e-06 | 4.57e-05 | 122 |
GO:009026316 | Esophagus | ESCC | positive regulation of canonical Wnt signaling pathway | 69/8552 | 106/18723 | 4.22e-05 | 3.39e-04 | 69 |
GO:003017716 | Esophagus | ESCC | positive regulation of Wnt signaling pathway | 87/8552 | 140/18723 | 6.18e-05 | 4.73e-04 | 87 |
GO:006156415 | Esophagus | ESCC | axon development | 251/8552 | 467/18723 | 2.41e-04 | 1.49e-03 | 251 |
GO:000740915 | Esophagus | ESCC | axonogenesis | 219/8552 | 418/18723 | 3.14e-03 | 1.31e-02 | 219 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LGR6 | SNV | Missense_Mutation | novel | c.2459N>G | p.Ala820Gly | p.A820G | Q9HBX8 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-66-2765-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LGR6 | SNV | Missense_Mutation | novel | c.444C>A | p.Asn148Lys | p.N148K | Q9HBX8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-77-A5GH-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LGR6 | SNV | Missense_Mutation | novel | c.651N>C | p.Leu217Phe | p.L217F | Q9HBX8 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-85-8355-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LGR6 | SNV | Missense_Mutation | novel | c.1270C>G | p.Leu424Val | p.L424V | Q9HBX8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-94-A5I4-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
LGR6 | deletion | Frame_Shift_Del | c.2661delG | p.Pro889LeufsTer11 | p.P889Lfs*11 | Q9HBX8 | protein_coding | TCGA-55-6985-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
LGR6 | deletion | Frame_Shift_Del | novel | c.1907delN | p.Glu637ArgfsTer4 | p.E637Rfs*4 | Q9HBX8 | protein_coding | TCGA-75-5126-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | SD | ||
LGR6 | deletion | Frame_Shift_Del | novel | c.976delN | p.Gly326AlafsTer8 | p.G326Afs*8 | Q9HBX8 | protein_coding | TCGA-98-A53I-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | navelbine | SD | ||
LGR6 | SNV | Missense_Mutation | novel | c.2515N>T | p.Arg839Trp | p.R839W | Q9HBX8 | protein_coding | tolerated(0.13) | possibly_damaging(0.772) | TCGA-CQ-5326-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
LGR6 | SNV | Missense_Mutation | novel | c.2593G>A | p.Asp865Asn | p.D865N | Q9HBX8 | protein_coding | deleterious(0.04) | benign(0.191) | TCGA-CR-6472-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
LGR6 | SNV | Missense_Mutation | novel | c.649N>G | p.Leu217Val | p.L217V | Q9HBX8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CV-7097-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
59352 | LGR6 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178102181 | ||
59352 | LGR6 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178101191 | ||
59352 | LGR6 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178100586 | ||
59352 | LGR6 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178102183 | ||
59352 | LGR6 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178100587 | ||
59352 | LGR6 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178100588 | ||
59352 | LGR6 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178100589 | ||
59352 | LGR6 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178102182 |
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