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Gene: KRT1 |
Gene summary for KRT1 |
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Gene information | Species | Human | Gene symbol | KRT1 | Gene ID | 3848 |
Gene name | keratin 1 | |
Gene Alias | CK1 | |
Cytomap | 12q13.13 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | P04264 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3848 | KRT1 | CA_HPV_1 | Human | Cervix | CC | 3.31e-02 | -1.97e-01 | 0.0264 |
3848 | KRT1 | CA_HPV_2 | Human | Cervix | CC | 6.26e-03 | -2.17e-01 | 0.0391 |
3848 | KRT1 | CA_HPV_3 | Human | Cervix | CC | 1.43e-02 | 4.87e-01 | 0.0414 |
3848 | KRT1 | N_HPV_1 | Human | Cervix | N_HPV | 1.93e-06 | -2.46e-01 | 0.0079 |
3848 | KRT1 | N_HPV_2 | Human | Cervix | N_HPV | 1.75e-13 | 6.51e-01 | -0.0131 |
3848 | KRT1 | Tumor | Human | Cervix | CC | 2.98e-30 | 9.28e-01 | 0.1241 |
3848 | KRT1 | sample3 | Human | Cervix | CC | 3.84e-11 | 5.60e-01 | 0.1387 |
3848 | KRT1 | H2 | Human | Cervix | HSIL_HPV | 9.00e-07 | -2.45e-01 | 0.0632 |
3848 | KRT1 | T1 | Human | Cervix | CC | 3.40e-05 | -2.54e-01 | 0.0918 |
3848 | KRT1 | T3 | Human | Cervix | CC | 6.96e-16 | 6.31e-01 | 0.1389 |
3848 | KRT1 | P1_S1_AK | Human | Skin | AK | 1.36e-04 | 8.04e-02 | -0.3399 |
3848 | KRT1 | P2_S3_AK | Human | Skin | AK | 8.77e-11 | -1.52e-02 | -0.3287 |
3848 | KRT1 | P2_S4_SCCIS | Human | Skin | SCCIS | 5.46e-16 | -5.70e-01 | -0.3043 |
3848 | KRT1 | P3_S6_AK | Human | Skin | AK | 7.17e-32 | 8.98e-01 | -0.3256 |
3848 | KRT1 | P5_S10_cSCC | Human | Skin | cSCC | 1.73e-25 | -7.80e-01 | -0.299 |
3848 | KRT1 | P4_cSCC | Human | Skin | cSCC | 2.42e-08 | 1.09e+00 | -0.00290000000000005 |
3848 | KRT1 | P10_cSCC | Human | Skin | cSCC | 1.04e-07 | -5.05e-01 | 0.1017 |
3848 | KRT1 | cSCC_p1 | Human | Skin | cSCC | 5.72e-06 | 4.94e-01 | -0.1916 |
3848 | KRT1 | cSCC_p10 | Human | Skin | cSCC | 3.93e-10 | 3.70e-01 | -0.2095 |
3848 | KRT1 | cSCC_p11 | Human | Skin | cSCC | 1.58e-18 | 4.56e-01 | -0.2102 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064179 | Breast | Precancer | regulation of translation | 67/1080 | 468/18723 | 4.71e-12 | 7.64e-10 | 67 |
GO:00457279 | Breast | Precancer | positive regulation of translation | 32/1080 | 136/18723 | 5.89e-12 | 9.27e-10 | 32 |
GO:00342509 | Breast | Precancer | positive regulation of cellular amide metabolic process | 33/1080 | 162/18723 | 1.72e-10 | 1.77e-08 | 33 |
GO:00100389 | Breast | Precancer | response to metal ion | 47/1080 | 373/18723 | 3.88e-07 | 1.79e-05 | 47 |
GO:00075688 | Breast | Precancer | aging | 41/1080 | 339/18723 | 5.95e-06 | 1.71e-04 | 41 |
GO:00487329 | Breast | Precancer | gland development | 49/1080 | 436/18723 | 6.11e-06 | 1.73e-04 | 49 |
GO:00971919 | Breast | Precancer | extrinsic apoptotic signaling pathway | 30/1080 | 219/18723 | 9.42e-06 | 2.50e-04 | 30 |
GO:00436273 | Breast | Precancer | response to estrogen | 15/1080 | 75/18723 | 2.06e-05 | 4.83e-04 | 15 |
GO:00342849 | Breast | Precancer | response to monosaccharide | 29/1080 | 225/18723 | 4.19e-05 | 9.00e-04 | 29 |
GO:00106319 | Breast | Precancer | epithelial cell migration | 40/1080 | 357/18723 | 4.57e-05 | 9.71e-04 | 40 |
GO:00901329 | Breast | Precancer | epithelium migration | 40/1080 | 360/18723 | 5.51e-05 | 1.14e-03 | 40 |
GO:00097439 | Breast | Precancer | response to carbohydrate | 31/1080 | 253/18723 | 6.15e-05 | 1.25e-03 | 31 |
GO:00901309 | Breast | Precancer | tissue migration | 40/1080 | 365/18723 | 7.48e-05 | 1.47e-03 | 40 |
GO:00093148 | Breast | Precancer | response to radiation | 47/1080 | 456/18723 | 8.39e-05 | 1.62e-03 | 47 |
GO:00018898 | Breast | Precancer | liver development | 21/1080 | 147/18723 | 1.08e-04 | 1.96e-03 | 21 |
GO:00102125 | Breast | Precancer | response to ionizing radiation | 21/1080 | 148/18723 | 1.19e-04 | 2.13e-03 | 21 |
GO:0045104 | Breast | Precancer | intermediate filament cytoskeleton organization | 11/1080 | 51/18723 | 1.26e-04 | 2.22e-03 | 11 |
GO:00713568 | Breast | Precancer | cellular response to tumor necrosis factor | 28/1080 | 229/18723 | 1.42e-04 | 2.45e-03 | 28 |
GO:00610088 | Breast | Precancer | hepaticobiliary system development | 21/1080 | 150/18723 | 1.45e-04 | 2.49e-03 | 21 |
GO:0045103 | Breast | Precancer | intermediate filament-based process | 11/1080 | 52/18723 | 1.52e-04 | 2.60e-03 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KRT1 | SNV | Missense_Mutation | rs60359468 | c.800G>A | p.Arg267Gln | p.R267Q | P04264 | protein_coding | deleterious(0.01) | possibly_damaging(0.676) | TCGA-BR-8590-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | PD |
KRT1 | SNV | Missense_Mutation | rs769968882 | c.1046G>A | p.Ser349Asn | p.S349N | P04264 | protein_coding | deleterious(0.01) | probably_damaging(0.965) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
KRT1 | SNV | Missense_Mutation | c.1142A>G | p.Gln381Arg | p.Q381R | P04264 | protein_coding | deleterious(0.02) | probably_damaging(0.978) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
KRT1 | SNV | Missense_Mutation | c.1927N>C | p.Thr643Pro | p.T643P | P04264 | protein_coding | deleterious_low_confidence(0) | benign(0.11) | TCGA-HU-A4GH-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KRT1 | SNV | Missense_Mutation | c.1070N>G | p.Gln357Arg | p.Q357R | P04264 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-HU-A4GH-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KRT1 | SNV | Missense_Mutation | novel | c.1786N>A | p.Gly596Ser | p.G596S | P04264 | protein_coding | tolerated_low_confidence(0.58) | benign(0.098) | TCGA-RD-A8NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
KRT1 | SNV | Missense_Mutation | novel | c.1340N>G | p.Leu447Arg | p.L447R | P04264 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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