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Gene: KIAA1522 |
Gene summary for KIAA1522 |
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Gene information | Species | Human | Gene symbol | KIAA1522 | Gene ID | 57648 |
Gene name | KIAA1522 | |
Gene Alias | KIAA1522 | |
Cytomap | 1p35.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9P206 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57648 | KIAA1522 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.18e-03 | 9.01e-02 | 0.0155 |
57648 | KIAA1522 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.68e-21 | 9.67e-01 | -0.1808 |
57648 | KIAA1522 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.34e-14 | 8.12e-01 | -0.0811 |
57648 | KIAA1522 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.50e-09 | 7.06e-01 | -0.1088 |
57648 | KIAA1522 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.38e-35 | 1.03e+00 | -0.1954 |
57648 | KIAA1522 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.37e-10 | 1.50e+00 | -0.2602 |
57648 | KIAA1522 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.31e-07 | 1.13e+00 | -0.2196 |
57648 | KIAA1522 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.20e-05 | 5.72e-01 | -0.1207 |
57648 | KIAA1522 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.32e-12 | 8.56e-01 | -0.1526 |
57648 | KIAA1522 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.56e-22 | 9.31e-01 | -0.1464 |
57648 | KIAA1522 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.19e-12 | 6.72e-01 | -0.1001 |
57648 | KIAA1522 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.78e-19 | 1.01e+00 | -0.059 |
57648 | KIAA1522 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.27e-07 | 9.26e-01 | -0.1706 |
57648 | KIAA1522 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.15e-02 | 5.92e-01 | -0.1462 |
57648 | KIAA1522 | HTA11_546_2000001011 | Human | Colorectum | AD | 5.06e-06 | 6.68e-01 | -0.0842 |
57648 | KIAA1522 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.83e-02 | 5.33e-01 | -0.0179 |
57648 | KIAA1522 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.88e-05 | 4.08e-01 | 0.096 |
57648 | KIAA1522 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.51e-03 | 7.19e-01 | 0.0131 |
57648 | KIAA1522 | HTA11_10623_2000001011 | Human | Colorectum | AD | 3.75e-05 | 8.14e-01 | -0.0177 |
57648 | KIAA1522 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.20e-04 | 8.05e-01 | 0.0171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA1522 | SNV | Missense_Mutation | novel | c.2569C>G | p.Gln857Glu | p.Q857E | Q9P206 | protein_coding | tolerated(0.39) | benign(0.003) | TCGA-CQ-7071-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
KIAA1522 | SNV | Missense_Mutation | novel | c.2821N>G | p.Leu941Val | p.L941V | Q9P206 | protein_coding | deleterious(0.01) | benign(0.048) | TCGA-CR-7364-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
KIAA1522 | SNV | Missense_Mutation | rs749647280 | c.2453N>T | p.Ser818Leu | p.S818L | Q9P206 | protein_coding | tolerated(0.22) | benign(0) | TCGA-CV-7099-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA1522 | SNV | Missense_Mutation | rs771438006 | c.2542N>A | p.Ala848Thr | p.A848T | Q9P206 | protein_coding | tolerated(0.8) | benign(0.038) | TCGA-CV-7432-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KIAA1522 | SNV | Missense_Mutation | novel | c.310N>T | p.His104Tyr | p.H104Y | Q9P206 | protein_coding | tolerated(0.9) | possibly_damaging(0.526) | TCGA-CV-A45V-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA1522 | SNV | Missense_Mutation | rs776048847 | c.1730C>G | p.Thr577Arg | p.T577R | Q9P206 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CV-A461-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KIAA1522 | deletion | Frame_Shift_Del | c.349delC | p.His117ThrfsTer24 | p.H117Tfs*24 | Q9P206 | protein_coding | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
KIAA1522 | SNV | Missense_Mutation | rs565146691 | c.938G>A | p.Arg313Gln | p.R313Q | Q9P206 | protein_coding | tolerated(0.21) | benign(0.117) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
KIAA1522 | deletion | Frame_Shift_Del | c.343delN | p.His117ThrfsTer24 | p.H117Tfs*24 | Q9P206 | protein_coding | TCGA-KK-A59V-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |||
KIAA1522 | SNV | Missense_Mutation | rs377305212 | c.763N>T | p.Arg255Cys | p.R255C | Q9P206 | protein_coding | tolerated(0.19) | possibly_damaging(0.742) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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