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Gene: KIAA0586 |
Gene summary for KIAA0586 |
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Gene information | Species | Human | Gene symbol | KIAA0586 | Gene ID | 9786 |
Gene name | KIAA0586 | |
Gene Alias | JBTS23 | |
Cytomap | 14q23.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q9BVV6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9786 | KIAA0586 | LZE4T | Human | Esophagus | ESCC | 4.91e-11 | 2.57e-01 | 0.0811 |
9786 | KIAA0586 | LZE5T | Human | Esophagus | ESCC | 8.31e-04 | 2.48e-01 | 0.0514 |
9786 | KIAA0586 | LZE21D1 | Human | Esophagus | HGIN | 2.96e-02 | 2.24e-01 | 0.0632 |
9786 | KIAA0586 | LZE24T | Human | Esophagus | ESCC | 1.33e-04 | 1.46e-01 | 0.0596 |
9786 | KIAA0586 | P1T-E | Human | Esophagus | ESCC | 3.86e-02 | 1.81e-01 | 0.0875 |
9786 | KIAA0586 | P2T-E | Human | Esophagus | ESCC | 2.05e-07 | 1.80e-01 | 0.1177 |
9786 | KIAA0586 | P4T-E | Human | Esophagus | ESCC | 1.41e-04 | 2.12e-01 | 0.1323 |
9786 | KIAA0586 | P5T-E | Human | Esophagus | ESCC | 1.78e-03 | 9.30e-02 | 0.1327 |
9786 | KIAA0586 | P8T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.49e-01 | 0.0889 |
9786 | KIAA0586 | P9T-E | Human | Esophagus | ESCC | 3.50e-03 | 8.31e-02 | 0.1131 |
9786 | KIAA0586 | P10T-E | Human | Esophagus | ESCC | 4.12e-11 | 1.92e-01 | 0.116 |
9786 | KIAA0586 | P12T-E | Human | Esophagus | ESCC | 9.02e-11 | 2.52e-01 | 0.1122 |
9786 | KIAA0586 | P15T-E | Human | Esophagus | ESCC | 1.33e-12 | 3.37e-01 | 0.1149 |
9786 | KIAA0586 | P16T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.22e-01 | 0.1153 |
9786 | KIAA0586 | P17T-E | Human | Esophagus | ESCC | 1.83e-02 | 1.70e-01 | 0.1278 |
9786 | KIAA0586 | P19T-E | Human | Esophagus | ESCC | 2.12e-03 | 2.46e-01 | 0.1662 |
9786 | KIAA0586 | P20T-E | Human | Esophagus | ESCC | 1.97e-02 | 1.17e-01 | 0.1124 |
9786 | KIAA0586 | P21T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.27e-01 | 0.1617 |
9786 | KIAA0586 | P23T-E | Human | Esophagus | ESCC | 4.80e-10 | 1.60e-01 | 0.108 |
9786 | KIAA0586 | P24T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.72e-01 | 0.1287 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA0586 | SNV | Missense_Mutation | c.3424N>T | p.Asp1142Tyr | p.D1142Y | Q9BVV6 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
KIAA0586 | SNV | Missense_Mutation | novel | c.1325N>T | p.Asn442Ile | p.N442I | Q9BVV6 | protein_coding | deleterious(0.01) | possibly_damaging(0.461) | TCGA-D1-A0ZR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIAA0586 | SNV | Missense_Mutation | c.2126N>A | p.Arg709Gln | p.R709Q | Q9BVV6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KIAA0586 | SNV | Missense_Mutation | novel | c.2995N>A | p.Glu999Lys | p.E999K | Q9BVV6 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
KIAA0586 | SNV | Missense_Mutation | c.775N>G | p.Ser259Ala | p.S259A | Q9BVV6 | protein_coding | tolerated(0.05) | possibly_damaging(0.775) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KIAA0586 | SNV | Missense_Mutation | c.2126N>A | p.Arg709Gln | p.R709Q | Q9BVV6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KIAA0586 | SNV | Missense_Mutation | novel | c.71N>C | p.Lys24Thr | p.K24T | Q9BVV6 | protein_coding | deleterious(0.02) | benign(0.12) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
KIAA0586 | SNV | Missense_Mutation | novel | c.307N>T | p.Asp103Tyr | p.D103Y | Q9BVV6 | protein_coding | deleterious(0) | possibly_damaging(0.66) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
KIAA0586 | SNV | Missense_Mutation | novel | c.4070T>G | p.Phe1357Cys | p.F1357C | Q9BVV6 | protein_coding | tolerated(0.31) | benign(0.007) | TCGA-DF-A2KV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIAA0586 | SNV | Missense_Mutation | c.2407C>A | p.Leu803Ile | p.L803I | Q9BVV6 | protein_coding | tolerated(0.32) | possibly_damaging(0.851) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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