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Gene: KCNG1 |
Gene summary for KCNG1 |
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Gene information | Species | Human | Gene symbol | KCNG1 | Gene ID | 3755 |
Gene name | potassium voltage-gated channel modifier subfamily G member 1 | |
Gene Alias | K13 | |
Cytomap | 20q13.13 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q86Y85 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3755 | KCNG1 | P2T-E | Human | Esophagus | ESCC | 4.16e-22 | 5.07e-01 | 0.1177 |
3755 | KCNG1 | P4T-E | Human | Esophagus | ESCC | 9.30e-06 | 2.08e-01 | 0.1323 |
3755 | KCNG1 | P5T-E | Human | Esophagus | ESCC | 8.40e-04 | 8.89e-02 | 0.1327 |
3755 | KCNG1 | P8T-E | Human | Esophagus | ESCC | 3.50e-02 | 6.85e-02 | 0.0889 |
3755 | KCNG1 | P10T-E | Human | Esophagus | ESCC | 2.03e-09 | 2.05e-01 | 0.116 |
3755 | KCNG1 | P12T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.41e-01 | 0.1122 |
3755 | KCNG1 | P16T-E | Human | Esophagus | ESCC | 4.30e-10 | 1.46e-01 | 0.1153 |
3755 | KCNG1 | P24T-E | Human | Esophagus | ESCC | 4.30e-10 | 3.09e-01 | 0.1287 |
3755 | KCNG1 | P26T-E | Human | Esophagus | ESCC | 1.30e-15 | 3.03e-01 | 0.1276 |
3755 | KCNG1 | P28T-E | Human | Esophagus | ESCC | 3.60e-13 | 2.27e-01 | 0.1149 |
3755 | KCNG1 | P31T-E | Human | Esophagus | ESCC | 9.35e-10 | 2.00e-01 | 0.1251 |
3755 | KCNG1 | P32T-E | Human | Esophagus | ESCC | 9.53e-09 | 2.93e-01 | 0.1666 |
3755 | KCNG1 | P37T-E | Human | Esophagus | ESCC | 4.23e-04 | 9.34e-02 | 0.1371 |
3755 | KCNG1 | P52T-E | Human | Esophagus | ESCC | 4.12e-11 | 2.60e-01 | 0.1555 |
3755 | KCNG1 | P61T-E | Human | Esophagus | ESCC | 2.91e-09 | 2.66e-01 | 0.099 |
3755 | KCNG1 | P65T-E | Human | Esophagus | ESCC | 3.83e-06 | 2.08e-01 | 0.0978 |
3755 | KCNG1 | P74T-E | Human | Esophagus | ESCC | 1.91e-03 | 1.35e-01 | 0.1479 |
3755 | KCNG1 | P76T-E | Human | Esophagus | ESCC | 9.56e-08 | 2.32e-01 | 0.1207 |
3755 | KCNG1 | P79T-E | Human | Esophagus | ESCC | 2.06e-08 | 2.09e-01 | 0.1154 |
3755 | KCNG1 | P83T-E | Human | Esophagus | ESCC | 1.01e-04 | 1.52e-01 | 0.1738 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00512592 | Esophagus | ESCC | protein complex oligomerization | 130/8552 | 238/18723 | 3.29e-03 | 1.36e-02 | 130 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KCNG1 | SNV | Missense_Mutation | c.43N>A | p.Ala15Thr | p.A15T | Q9UIX4 | protein_coding | tolerated_low_confidence(0.46) | benign(0.166) | TCGA-BR-7959-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR | |
KCNG1 | SNV | Missense_Mutation | c.394C>T | p.Arg132Cys | p.R132C | Q9UIX4 | protein_coding | deleterious(0.04) | probably_damaging(0.93) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KCNG1 | SNV | Missense_Mutation | c.394N>T | p.Arg132Cys | p.R132C | Q9UIX4 | protein_coding | deleterious(0.04) | probably_damaging(0.93) | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR | |
KCNG1 | SNV | Missense_Mutation | c.1439N>A | p.Arg480Gln | p.R480Q | Q9UIX4 | protein_coding | tolerated(0.13) | benign(0.11) | TCGA-BR-8483-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
KCNG1 | SNV | Missense_Mutation | c.845N>G | p.Glu282Gly | p.E282G | Q9UIX4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
KCNG1 | SNV | Missense_Mutation | c.345C>A | p.Phe115Leu | p.F115L | Q9UIX4 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
KCNG1 | SNV | Missense_Mutation | c.395N>A | p.Arg132His | p.R132H | Q9UIX4 | protein_coding | deleterious(0.02) | possibly_damaging(0.829) | TCGA-D7-A4YU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | SD | |
KCNG1 | SNV | Missense_Mutation | novel | c.775G>T | p.Gly259Cys | p.G259C | Q9UIX4 | protein_coding | deleterious(0) | possibly_damaging(0.759) | TCGA-D7-A6EZ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
KCNG1 | SNV | Missense_Mutation | c.1340N>C | p.Ser447Thr | p.S447T | Q9UIX4 | protein_coding | deleterious(0.04) | probably_damaging(0.976) | TCGA-FP-7916-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
KCNG1 | SNV | Missense_Mutation | novel | c.487N>A | p.Gly163Ser | p.G163S | Q9UIX4 | protein_coding | tolerated(0.51) | benign(0.166) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3755 | KCNG1 | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL113461 | TEDISAMIL | |
3755 | KCNG1 | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL1200728 | GUANIDINE HYDROCHLORIDE | |
3755 | KCNG1 | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL2107762 | NERISPIRDINE | |
3755 | KCNG1 | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL284348 | DALFAMPRIDINE |
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