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Gene: KCND3 |
Gene summary for KCND3 |
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Gene information | Species | Human | Gene symbol | KCND3 | Gene ID | 3752 |
Gene name | potassium voltage-gated channel subfamily D member 3 | |
Gene Alias | BRGDA9 | |
Cytomap | 1p13.2 | |
Gene Type | protein-coding | GO ID | GO:0001508 | UniProtAcc | Q9UK17 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3752 | KCND3 | 048752_1579-all-cells | Human | Prostate | BPH | 5.04e-18 | 4.25e-01 | 0.1008 |
3752 | KCND3 | 052095_1628-all-cells | Human | Prostate | BPH | 9.33e-11 | 3.24e-01 | 0.1032 |
3752 | KCND3 | 052097_1595-all-cells | Human | Prostate | BPH | 1.40e-12 | 3.79e-01 | 0.0972 |
3752 | KCND3 | 052099_1652-all-cells | Human | Prostate | BPH | 1.18e-13 | 3.97e-01 | 0.1038 |
3752 | KCND3 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 3.88e-03 | 3.82e-01 | 0.1604 |
3752 | KCND3 | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 1.57e-02 | 5.08e-01 | 0.1622 |
3752 | KCND3 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 1.90e-05 | 3.71e-01 | 0.1575 |
3752 | KCND3 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 7.85e-03 | 3.05e-01 | 0.1545 |
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Tissue | Expression Dynamics | Abbreviation |
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00300489 | Prostate | BPH | actin filament-based movement | 38/3107 | 127/18723 | 1.31e-04 | 1.18e-03 | 38 |
GO:00030127 | Prostate | BPH | muscle system process | 103/3107 | 452/18723 | 3.54e-04 | 2.62e-03 | 103 |
GO:00860018 | Prostate | BPH | cardiac muscle cell action potential | 21/3107 | 76/18723 | 1.05e-02 | 4.39e-02 | 21 |
GO:000301214 | Prostate | Tumor | muscle system process | 105/3246 | 452/18723 | 7.44e-04 | 5.14e-03 | 105 |
GO:003004815 | Prostate | Tumor | actin filament-based movement | 36/3246 | 127/18723 | 1.38e-03 | 8.62e-03 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501720 | Prostate | BPH | Spinocerebellar ataxia | 55/1718 | 143/8465 | 3.63e-07 | 3.74e-06 | 2.32e-06 | 55 |
hsa05017110 | Prostate | BPH | Spinocerebellar ataxia | 55/1718 | 143/8465 | 3.63e-07 | 3.74e-06 | 2.32e-06 | 55 |
hsa0501724 | Prostate | Tumor | Spinocerebellar ataxia | 54/1791 | 143/8465 | 3.50e-06 | 3.13e-05 | 1.94e-05 | 54 |
hsa0501734 | Prostate | Tumor | Spinocerebellar ataxia | 54/1791 | 143/8465 | 3.50e-06 | 3.13e-05 | 1.94e-05 | 54 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KCND3 | SNV | Missense_Mutation | c.213N>T | p.Lys71Asn | p.K71N | Q9UK17 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-NJ-A4YI-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
KCND3 | SNV | Missense_Mutation | c.428A>G | p.Asn143Ser | p.N143S | Q9UK17 | protein_coding | tolerated(0.06) | benign(0.028) | TCGA-22-5491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KCND3 | SNV | Missense_Mutation | novel | c.263N>A | p.Pro88His | p.P88H | Q9UK17 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-46-3768-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | SD |
KCND3 | SNV | Missense_Mutation | c.1149N>A | p.Phe383Leu | p.F383L | Q9UK17 | protein_coding | tolerated(0.23) | benign(0.048) | TCGA-56-8201-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KCND3 | SNV | Missense_Mutation | c.1813T>A | p.Cys605Ser | p.C605S | Q9UK17 | protein_coding | tolerated_low_confidence(0.09) | benign(0.05) | TCGA-60-2726-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KCND3 | SNV | Missense_Mutation | c.539N>T | p.Thr180Met | p.T180M | Q9UK17 | protein_coding | deleterious(0.03) | possibly_damaging(0.561) | TCGA-66-2782-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unspecific | PD | ||
KCND3 | SNV | Missense_Mutation | novel | c.61C>A | p.Pro21Thr | p.P21T | Q9UK17 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-NC-A5HF-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
KCND3 | deletion | Frame_Shift_Del | novel | c.365delN | p.Gly122AlafsTer67 | p.G122Afs*67 | Q9UK17 | protein_coding | TCGA-52-7809-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
KCND3 | SNV | Missense_Mutation | rs760710842 | c.1876N>A | p.Glu626Lys | p.E626K | Q9UK17 | protein_coding | deleterious_low_confidence(0.01) | benign(0.37) | TCGA-D6-A6ES-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KCND3 | SNV | Missense_Mutation | rs751093070 | c.1033G>A | p.Gly345Ser | p.G345S | Q9UK17 | protein_coding | tolerated(0.11) | benign(0.224) | TCGA-EJ-5511-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3752 | KCND3 | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL1200728 | GUANIDINE HYDROCHLORIDE | |
3752 | KCND3 | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL284348 | DALFAMPRIDINE | |
3752 | KCND3 | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL113461 | TEDISAMIL | |
3752 | KCND3 | ION CHANNEL, DRUGGABLE GENOME | Sodium bicarbonate | |||
3752 | KCND3 | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL2107762 | NERISPIRDINE |
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