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Gene: IL12RB2 |
Gene summary for IL12RB2 |
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Gene information | Species | Human | Gene symbol | IL12RB2 | Gene ID | 3595 |
Gene name | interleukin 12 receptor subunit beta 2 | |
Gene Alias | IL12RB2 | |
Cytomap | 1p31.3 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | B4DGA4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3595 | IL12RB2 | CCI_1 | Human | Cervix | CC | 1.30e-17 | 6.75e-01 | 0.528 |
3595 | IL12RB2 | CCI_2 | Human | Cervix | CC | 2.30e-10 | 5.16e-01 | 0.5249 |
3595 | IL12RB2 | CCI_3 | Human | Cervix | CC | 1.77e-02 | 2.18e-01 | 0.516 |
3595 | IL12RB2 | P5T-E | Human | Esophagus | ESCC | 3.50e-02 | 8.68e-02 | 0.1327 |
3595 | IL12RB2 | P9T-E | Human | Esophagus | ESCC | 5.23e-05 | 1.89e-01 | 0.1131 |
3595 | IL12RB2 | P10T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.32e-01 | 0.116 |
3595 | IL12RB2 | P23T-E | Human | Esophagus | ESCC | 1.66e-06 | 1.93e-01 | 0.108 |
3595 | IL12RB2 | P24T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.02e-01 | 0.1287 |
3595 | IL12RB2 | P26T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.02e-01 | 0.1276 |
3595 | IL12RB2 | P52T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.97e-01 | 0.1555 |
3595 | IL12RB2 | P80T-E | Human | Esophagus | ESCC | 3.99e-15 | 4.91e-01 | 0.155 |
3595 | IL12RB2 | P83T-E | Human | Esophagus | ESCC | 4.97e-05 | 1.56e-01 | 0.1738 |
3595 | IL12RB2 | P89T-E | Human | Esophagus | ESCC | 5.33e-06 | 2.98e-01 | 0.1752 |
3595 | IL12RB2 | P91T-E | Human | Esophagus | ESCC | 5.34e-06 | 6.19e-01 | 0.1828 |
3595 | IL12RB2 | P107T-E | Human | Esophagus | ESCC | 2.82e-13 | 2.95e-01 | 0.171 |
3595 | IL12RB2 | P128T-E | Human | Esophagus | ESCC | 9.30e-22 | 5.68e-01 | 0.1241 |
3595 | IL12RB2 | P130T-E | Human | Esophagus | ESCC | 7.52e-23 | 4.53e-01 | 0.1676 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00018197 | Cervix | CC | positive regulation of cytokine production | 95/2311 | 467/18723 | 4.88e-07 | 1.85e-05 | 95 |
GO:00022379 | Cervix | CC | response to molecule of bacterial origin | 78/2311 | 363/18723 | 5.55e-07 | 2.06e-05 | 78 |
GO:00324969 | Cervix | CC | response to lipopolysaccharide | 74/2311 | 343/18723 | 9.15e-07 | 3.25e-05 | 74 |
GO:00192213 | Cervix | CC | cytokine-mediated signaling pathway | 84/2311 | 472/18723 | 3.25e-04 | 3.44e-03 | 84 |
GO:003249619 | Esophagus | ESCC | response to lipopolysaccharide | 191/8552 | 343/18723 | 1.11e-04 | 7.73e-04 | 191 |
GO:00182124 | Esophagus | ESCC | peptidyl-tyrosine modification | 202/8552 | 378/18723 | 1.34e-03 | 6.39e-03 | 202 |
GO:00181084 | Esophagus | ESCC | peptidyl-tyrosine phosphorylation | 200/8552 | 375/18723 | 1.60e-03 | 7.45e-03 | 200 |
GO:000223719 | Esophagus | ESCC | response to molecule of bacterial origin | 194/8552 | 363/18723 | 1.64e-03 | 7.61e-03 | 194 |
GO:000181916 | Esophagus | ESCC | positive regulation of cytokine production | 244/8552 | 467/18723 | 2.29e-03 | 1.01e-02 | 244 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04658 | Cervix | CC | Th1 and Th2 cell differentiation | 24/1267 | 92/8465 | 3.71e-03 | 1.34e-02 | 7.91e-03 | 24 |
hsa046581 | Cervix | CC | Th1 and Th2 cell differentiation | 24/1267 | 92/8465 | 3.71e-03 | 1.34e-02 | 7.91e-03 | 24 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IL12RB2 | SNV | Missense_Mutation | novel | c.2234N>G | p.His745Arg | p.H745R | Q99665 | protein_coding | tolerated(0.34) | benign(0.012) | TCGA-NC-A5HN-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
IL12RB2 | SNV | Missense_Mutation | novel | c.530A>C | p.Tyr177Ser | p.Y177S | Q99665 | protein_coding | tolerated(0.27) | benign(0.089) | TCGA-BA-6872-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unspecific | PD | |
IL12RB2 | SNV | Missense_Mutation | novel | c.2302N>G | p.Lys768Glu | p.K768E | Q99665 | protein_coding | deleterious(0) | possibly_damaging(0.541) | TCGA-CN-4727-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
IL12RB2 | SNV | Missense_Mutation | novel | c.39N>T | p.Met13Ile | p.M13I | Q99665 | protein_coding | tolerated(1) | benign(0) | TCGA-CQ-7069-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IL12RB2 | SNV | Missense_Mutation | novel | c.89N>C | p.Arg30Thr | p.R30T | Q99665 | protein_coding | deleterious(0.01) | possibly_damaging(0.516) | TCGA-CR-6480-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
IL12RB2 | SNV | Missense_Mutation | novel | c.2416N>A | p.Asp806Asn | p.D806N | Q99665 | protein_coding | deleterious(0.03) | benign(0.007) | TCGA-CV-7178-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
IL12RB2 | SNV | Missense_Mutation | novel | c.274C>G | p.Leu92Val | p.L92V | Q99665 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CV-7433-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
IL12RB2 | SNV | Missense_Mutation | novel | c.2110N>A | p.Pro704Thr | p.P704T | Q99665 | protein_coding | tolerated(0.84) | benign(0.003) | TCGA-F7-7848-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IL12RB2 | SNV | Missense_Mutation | novel | c.2111N>A | p.Pro704Gln | p.P704Q | Q99665 | protein_coding | deleterious(0.01) | possibly_damaging(0.769) | TCGA-F7-7848-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IL12RB2 | SNV | Missense_Mutation | c.2452N>A | p.Ser818Thr | p.S818T | Q99665 | protein_coding | tolerated(0.18) | benign(0.073) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3595 | IL12RB2 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | INCELL-1001+ AD-1001 | |||
3595 | IL12RB2 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | AS1409 | |||
3595 | IL12RB2 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | DENILEUKIN DIFTITOX |
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