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Gene: HNRNPM |
Gene summary for HNRNPM |
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Gene information | Species | Human | Gene symbol | HNRNPM | Gene ID | 4670 |
Gene name | heterogeneous nuclear ribonucleoprotein M | |
Gene Alias | CEAR | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | Q59ES8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4670 | HNRNPM | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.37e-02 | 3.01e-01 | 0.0155 |
4670 | HNRNPM | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.61e-02 | 4.34e-01 | -0.1808 |
4670 | HNRNPM | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.80e-07 | 7.25e-01 | -0.0811 |
4670 | HNRNPM | HTA11_78_2000001011 | Human | Colorectum | AD | 9.21e-03 | 4.92e-01 | -0.1088 |
4670 | HNRNPM | HTA11_347_2000001011 | Human | Colorectum | AD | 9.04e-12 | 5.86e-01 | -0.1954 |
4670 | HNRNPM | HTA11_411_2000001011 | Human | Colorectum | SER | 1.08e-05 | 1.01e+00 | -0.2602 |
4670 | HNRNPM | HTA11_83_2000001011 | Human | Colorectum | SER | 1.57e-04 | 5.60e-01 | -0.1526 |
4670 | HNRNPM | HTA11_696_2000001011 | Human | Colorectum | AD | 8.71e-13 | 7.54e-01 | -0.1464 |
4670 | HNRNPM | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.93e-13 | 9.68e-01 | -0.059 |
4670 | HNRNPM | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.97e-08 | 7.68e-01 | -0.0179 |
4670 | HNRNPM | HTA11_866_3004761011 | Human | Colorectum | AD | 9.08e-18 | 1.03e+00 | 0.096 |
4670 | HNRNPM | HTA11_7663_2000001011 | Human | Colorectum | SER | 5.14e-07 | 9.86e-01 | 0.0131 |
4670 | HNRNPM | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.53e-06 | 7.90e-01 | -0.0177 |
4670 | HNRNPM | HTA11_6801_2000001011 | Human | Colorectum | SER | 6.04e-08 | 1.08e+00 | 0.0171 |
4670 | HNRNPM | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.71e-06 | 6.23e-01 | 0.0338 |
4670 | HNRNPM | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.51e-28 | 1.19e+00 | 0.0674 |
4670 | HNRNPM | HTA11_7469_2000001011 | Human | Colorectum | AD | 5.81e-06 | 1.07e+00 | -0.0124 |
4670 | HNRNPM | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.86e-04 | 5.81e-01 | 0.0588 |
4670 | HNRNPM | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.92e-32 | 1.34e+00 | 0.294 |
4670 | HNRNPM | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.07e-17 | 1.79e+00 | 0.3487 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:1903311 | Colorectum | AD | regulation of mRNA metabolic process | 117/3918 | 288/18723 | 1.69e-14 | 4.23e-12 | 117 |
GO:0006401 | Colorectum | AD | RNA catabolic process | 102/3918 | 278/18723 | 8.64e-10 | 6.76e-08 | 102 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0006402 | Colorectum | AD | mRNA catabolic process | 87/3918 | 232/18723 | 4.40e-09 | 2.84e-07 | 87 |
GO:0006979 | Colorectum | AD | response to oxidative stress | 145/3918 | 446/18723 | 5.16e-09 | 3.23e-07 | 145 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0061013 | Colorectum | AD | regulation of mRNA catabolic process | 64/3918 | 166/18723 | 1.44e-07 | 6.59e-06 | 64 |
GO:0043487 | Colorectum | AD | regulation of RNA stability | 63/3918 | 170/18723 | 9.17e-07 | 3.12e-05 | 63 |
GO:0043488 | Colorectum | AD | regulation of mRNA stability | 59/3918 | 158/18723 | 1.50e-06 | 4.66e-05 | 59 |
GO:0000380 | Colorectum | AD | alternative mRNA splicing, via spliceosome | 33/3918 | 77/18723 | 1.13e-05 | 2.55e-04 | 33 |
GO:00083801 | Colorectum | SER | RNA splicing | 123/2897 | 434/18723 | 3.84e-12 | 8.41e-10 | 123 |
GO:00003751 | Colorectum | SER | RNA splicing, via transesterification reactions | 90/2897 | 324/18723 | 8.68e-09 | 7.50e-07 | 90 |
GO:00003771 | Colorectum | SER | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 89/2897 | 320/18723 | 9.82e-09 | 8.14e-07 | 89 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa03040 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030401 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030402 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030403 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030404 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa030405 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa030409 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304014 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304024 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304034 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304018 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304019 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa030407 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304012 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304022 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304032 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304016 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304017 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HNRNPM | SNV | Missense_Mutation | c.301N>A | p.Val101Met | p.V101M | P52272 | protein_coding | deleterious(0.01) | benign(0.329) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HNRNPM | SNV | Missense_Mutation | c.1139N>C | p.Leu380Pro | p.L380P | P52272 | protein_coding | deleterious(0.05) | benign(0.07) | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HNRNPM | SNV | Missense_Mutation | c.470T>C | p.Met157Thr | p.M157T | P52272 | protein_coding | tolerated(0.09) | benign(0.062) | TCGA-CD-A4MJ-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
HNRNPM | SNV | Missense_Mutation | rs770001698 | c.1603G>A | p.Ala535Thr | p.A535T | P52272 | protein_coding | tolerated(0.26) | benign(0.005) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
HNRNPM | SNV | Missense_Mutation | novel | c.319N>A | p.Ala107Thr | p.A107T | P52272 | protein_coding | deleterious(0.01) | possibly_damaging(0.621) | TCGA-D7-A6F2-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HNRNPM | SNV | Missense_Mutation | c.877N>T | p.Arg293Cys | p.R293C | P52272 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-F1-6177-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HNRNPM | SNV | Missense_Mutation | rs759532478 | c.1817G>A | p.Arg606His | p.R606H | P52272 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-FP-A9TM-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
HNRNPM | SNV | Missense_Mutation | rs746414049 | c.1447N>A | p.Val483Met | p.V483M | P52272 | protein_coding | tolerated(0.69) | benign(0.166) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
HNRNPM | SNV | Missense_Mutation | c.1454G>A | p.Arg485His | p.R485H | P52272 | protein_coding | tolerated(0.08) | benign(0.382) | TCGA-HU-A4GX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | SD | |
HNRNPM | SNV | Missense_Mutation | novel | c.898G>A | p.Gly300Ser | p.G300S | P52272 | protein_coding | deleterious(0) | possibly_damaging(0.612) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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