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Gene: HIVEP2 |
Gene summary for HIVEP2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | HIVEP2 | Gene ID | 3097 |
Gene name | HIVEP zinc finger 2 | |
Gene Alias | HIV-EP2 | |
Cytomap | 6q24.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P31629 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3097 | HIVEP2 | CCI_1 | Human | Cervix | CC | 2.89e-10 | 1.01e+00 | 0.528 |
3097 | HIVEP2 | CCI_2 | Human | Cervix | CC | 5.21e-11 | 1.17e+00 | 0.5249 |
3097 | HIVEP2 | CCI_3 | Human | Cervix | CC | 2.80e-25 | 1.10e+00 | 0.516 |
3097 | HIVEP2 | H2 | Human | Cervix | HSIL_HPV | 6.14e-04 | 2.05e-01 | 0.0632 |
3097 | HIVEP2 | AEH-subject1 | Human | Endometrium | AEH | 3.63e-52 | 9.78e-01 | -0.3059 |
3097 | HIVEP2 | AEH-subject2 | Human | Endometrium | AEH | 6.81e-25 | 6.88e-01 | -0.2525 |
3097 | HIVEP2 | AEH-subject3 | Human | Endometrium | AEH | 2.38e-14 | 5.59e-01 | -0.2576 |
3097 | HIVEP2 | AEH-subject4 | Human | Endometrium | AEH | 3.13e-25 | 7.83e-01 | -0.2657 |
3097 | HIVEP2 | AEH-subject5 | Human | Endometrium | AEH | 7.29e-55 | 1.27e+00 | -0.2953 |
3097 | HIVEP2 | EEC-subject1 | Human | Endometrium | EEC | 3.12e-35 | 8.38e-01 | -0.2682 |
3097 | HIVEP2 | EEC-subject2 | Human | Endometrium | EEC | 3.15e-22 | 6.27e-01 | -0.2607 |
3097 | HIVEP2 | EEC-subject3 | Human | Endometrium | EEC | 8.70e-31 | 7.32e-01 | -0.2525 |
3097 | HIVEP2 | EEC-subject4 | Human | Endometrium | EEC | 2.46e-26 | 7.53e-01 | -0.2571 |
3097 | HIVEP2 | EEC-subject5 | Human | Endometrium | EEC | 3.47e-16 | 5.47e-01 | -0.249 |
3097 | HIVEP2 | GSM5276934 | Human | Endometrium | EEC | 1.07e-08 | 3.60e-01 | -0.0913 |
3097 | HIVEP2 | GSM5276937 | Human | Endometrium | EEC | 8.67e-04 | 2.59e-01 | -0.0897 |
3097 | HIVEP2 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.25e-06 | -6.37e-03 | -0.1869 |
3097 | HIVEP2 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.20e-02 | -3.85e-02 | -0.1875 |
3097 | HIVEP2 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.12e-05 | -7.23e-03 | -0.1883 |
3097 | HIVEP2 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.74e-09 | 8.34e-02 | -0.1917 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIVEP2 | SNV | Missense_Mutation | rs773500636 | c.590C>T | p.Ala197Val | p.A197V | P31629 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HIVEP2 | SNV | Missense_Mutation | novel | c.5117N>A | p.Thr1706Asn | p.T1706N | P31629 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIVEP2 | SNV | Missense_Mutation | novel | c.2764N>A | p.Gln922Lys | p.Q922K | P31629 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIVEP2 | SNV | Missense_Mutation | rs778150820 | c.2270N>A | p.Arg757His | p.R757H | P31629 | protein_coding | tolerated(0.13) | benign(0.044) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIVEP2 | SNV | Missense_Mutation | rs746928726 | c.5936N>A | p.Arg1979Gln | p.R1979Q | P31629 | protein_coding | tolerated(1) | benign(0) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HIVEP2 | SNV | Missense_Mutation | rs748022954 | c.4808N>A | p.Arg1603Gln | p.R1603Q | P31629 | protein_coding | tolerated(0.35) | benign(0.017) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
HIVEP2 | SNV | Missense_Mutation | novel | c.5474N>A | p.Arg1825Gln | p.R1825Q | P31629 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
HIVEP2 | SNV | Missense_Mutation | novel | c.4147N>A | p.Ala1383Thr | p.A1383T | P31629 | protein_coding | tolerated(0.33) | benign(0) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
HIVEP2 | SNV | Missense_Mutation | novel | c.5821C>T | p.Pro1941Ser | p.P1941S | P31629 | protein_coding | tolerated(0.05) | possibly_damaging(0.702) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
HIVEP2 | SNV | Missense_Mutation | novel | c.4974T>G | p.Asn1658Lys | p.N1658K | P31629 | protein_coding | deleterious(0) | benign(0.11) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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