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Gene: HCFC2 |
Gene summary for HCFC2 |
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Gene information | Species | Human | Gene symbol | HCFC2 | Gene ID | 29915 |
Gene name | host cell factor C2 | |
Gene Alias | HCF-2 | |
Cytomap | 12q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9Y5Z7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29915 | HCFC2 | male-WTA | Human | Thyroid | PTC | 5.53e-08 | 3.96e-02 | 0.1037 |
29915 | HCFC2 | PTC01 | Human | Thyroid | PTC | 3.51e-05 | 4.57e-02 | 0.1899 |
29915 | HCFC2 | PTC04 | Human | Thyroid | PTC | 2.02e-12 | 1.41e-01 | 0.1927 |
29915 | HCFC2 | PTC05 | Human | Thyroid | PTC | 5.84e-04 | 1.34e-01 | 0.2065 |
29915 | HCFC2 | PTC06 | Human | Thyroid | PTC | 1.62e-12 | 2.31e-01 | 0.2057 |
29915 | HCFC2 | PTC07 | Human | Thyroid | PTC | 2.18e-09 | 1.77e-01 | 0.2044 |
29915 | HCFC2 | ATC12 | Human | Thyroid | ATC | 2.03e-11 | 2.50e-01 | 0.34 |
29915 | HCFC2 | ATC13 | Human | Thyroid | ATC | 3.49e-18 | 2.79e-01 | 0.34 |
29915 | HCFC2 | ATC2 | Human | Thyroid | ATC | 3.93e-09 | 5.84e-01 | 0.34 |
29915 | HCFC2 | ATC4 | Human | Thyroid | ATC | 2.57e-13 | 3.42e-01 | 0.34 |
29915 | HCFC2 | ATC5 | Human | Thyroid | ATC | 3.00e-22 | 3.11e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032113 | Thyroid | PTC | viral process | 236/5968 | 415/18723 | 2.48e-26 | 8.24e-24 | 236 |
GO:000632520 | Thyroid | PTC | chromatin organization | 183/5968 | 409/18723 | 2.55e-08 | 5.70e-07 | 183 |
GO:00063385 | Thyroid | PTC | chromatin remodeling | 106/5968 | 255/18723 | 6.56e-04 | 4.13e-03 | 106 |
GO:001603234 | Thyroid | ATC | viral process | 241/6293 | 415/18723 | 5.50e-25 | 2.04e-22 | 241 |
GO:0006325110 | Thyroid | ATC | chromatin organization | 189/6293 | 409/18723 | 6.40e-08 | 1.13e-06 | 189 |
GO:000633813 | Thyroid | ATC | chromatin remodeling | 109/6293 | 255/18723 | 1.38e-03 | 7.15e-03 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
HCFC2 | cDC | Lung | Healthy | ESD,ERAP2,EPSTI1, etc. | 4.03e-03 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HCFC2 | SNV | Missense_Mutation | novel | c.1277C>A | p.Pro426His | p.P426H | Q9Y5Z7 | protein_coding | tolerated(0.06) | benign(0) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
HCFC2 | SNV | Missense_Mutation | novel | c.1830G>T | p.Leu610Phe | p.L610F | Q9Y5Z7 | protein_coding | tolerated(0.37) | benign(0.216) | TCGA-CV-5434-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
HCFC2 | SNV | Missense_Mutation | novel | c.2216N>T | p.Thr739Ile | p.T739I | Q9Y5Z7 | protein_coding | deleterious(0.03) | probably_damaging(0.942) | TCGA-IQ-7630-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | CR |
HCFC2 | SNV | Missense_Mutation | c.1423N>T | p.His475Tyr | p.H475Y | Q9Y5Z7 | protein_coding | tolerated(0.15) | benign(0.043) | TCGA-CH-5792-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |
HCFC2 | SNV | Missense_Mutation | c.690N>C | p.Met230Ile | p.M230I | Q9Y5Z7 | protein_coding | deleterious(0.03) | benign(0.1) | TCGA-EJ-7782-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD | |
HCFC2 | SNV | Missense_Mutation | novel | c.1666G>T | p.Val556Phe | p.V556F | Q9Y5Z7 | protein_coding | deleterious(0.02) | benign(0.282) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
HCFC2 | SNV | Missense_Mutation | c.1744G>A | p.Glu582Lys | p.E582K | Q9Y5Z7 | protein_coding | tolerated(0.54) | benign(0) | TCGA-CG-5719-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
HCFC2 | SNV | Missense_Mutation | rs144090047 | c.970N>A | p.Gly324Ser | p.G324S | Q9Y5Z7 | protein_coding | tolerated(0.06) | probably_damaging(0.976) | TCGA-R5-A805-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
HCFC2 | SNV | Missense_Mutation | novel | c.653N>A | p.Arg218His | p.R218H | Q9Y5Z7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
HCFC2 | insertion | Frame_Shift_Ins | novel | c.983_984insT | p.Trp330LeufsTer13 | p.W330Lfs*13 | Q9Y5Z7 | protein_coding | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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