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Gene: GRM6 |
Gene summary for GRM6 |
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Gene information | Species | Human | Gene symbol | GRM6 | Gene ID | 2916 |
Gene name | glutamate metabotropic receptor 6 | |
Gene Alias | CSNB1B | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0001654 | UniProtAcc | O15303 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2916 | GRM6 | HCC1 | Human | Liver | HCC | 1.78e-03 | 8.39e-01 | 0.5336 |
2916 | GRM6 | HCC2 | Human | Liver | HCC | 4.50e-19 | 1.21e+00 | 0.5341 |
2916 | GRM6 | HCC5 | Human | Liver | HCC | 1.15e-18 | 8.83e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00093146 | Liver | HCC | response to radiation | 223/7958 | 456/18723 | 3.08e-03 | 1.43e-02 | 223 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRM6 | SNV | Missense_Mutation | novel | c.1250N>T | p.Ser417Ile | p.S417I | O15303 | protein_coding | deleterious(0.02) | benign(0.296) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
GRM6 | SNV | Missense_Mutation | novel | c.2411N>C | p.Phe804Ser | p.F804S | O15303 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRM6 | SNV | Missense_Mutation | novel | c.1294N>A | p.Ala432Thr | p.A432T | O15303 | protein_coding | tolerated(0.45) | benign(0.062) | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRM6 | SNV | Missense_Mutation | rs151156480 | c.1846N>A | p.Val616Ile | p.V616I | O15303 | protein_coding | tolerated(0.11) | possibly_damaging(0.835) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
GRM6 | insertion | Frame_Shift_Ins | novel | c.767_768insA | p.Pro257AlafsTer26 | p.P257Afs*26 | O15303 | protein_coding | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | ||
GRM6 | SNV | Missense_Mutation | novel | c.1610N>A | p.Cys537Tyr | p.C537Y | O15303 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BC-4073-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | sorafenib | SD |
GRM6 | SNV | Missense_Mutation | c.1449C>A | p.Ser483Arg | p.S483R | O15303 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-CC-A5UC-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
GRM6 | SNV | Missense_Mutation | novel | c.2200N>C | p.Asp734His | p.D734H | O15303 | protein_coding | tolerated(0.22) | possibly_damaging(0.873) | TCGA-05-4244-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
GRM6 | SNV | Missense_Mutation | c.683G>C | p.Ser228Thr | p.S228T | O15303 | protein_coding | tolerated(0.54) | possibly_damaging(0.593) | TCGA-05-5423-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GRM6 | SNV | Missense_Mutation | c.1718N>A | p.Pro573His | p.P573H | O15303 | protein_coding | deleterious(0.02) | benign(0.03) | TCGA-44-6144-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2916 | GRM6 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 135651172 | ||
2916 | GRM6 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135650510 | ||
2916 | GRM6 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135650421 | ||
2916 | GRM6 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135650554 | EGLUMEGAD | |
2916 | GRM6 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 178100385 | ||
2916 | GRM6 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135650423 | ||
2916 | GRM6 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135651501 | ||
2916 | GRM6 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135649666 | ||
2916 | GRM6 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135651511 | ||
2916 | GRM6 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135650556 |
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