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Gene: GRIPAP1 |
Gene summary for GRIPAP1 |
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Gene information | Species | Human | Gene symbol | GRIPAP1 | Gene ID | 56850 |
Gene name | GRIP1 associated protein 1 | |
Gene Alias | GRASP-1 | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q4V328 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56850 | GRIPAP1 | LZE4T | Human | Esophagus | ESCC | 1.06e-09 | 2.30e-01 | 0.0811 |
56850 | GRIPAP1 | LZE7T | Human | Esophagus | ESCC | 3.69e-07 | 3.34e-01 | 0.0667 |
56850 | GRIPAP1 | LZE8T | Human | Esophagus | ESCC | 1.51e-07 | 2.15e-01 | 0.067 |
56850 | GRIPAP1 | LZE20T | Human | Esophagus | ESCC | 2.76e-03 | 1.26e-01 | 0.0662 |
56850 | GRIPAP1 | LZE24T | Human | Esophagus | ESCC | 1.33e-08 | 2.67e-01 | 0.0596 |
56850 | GRIPAP1 | P1T-E | Human | Esophagus | ESCC | 1.08e-08 | 3.98e-01 | 0.0875 |
56850 | GRIPAP1 | P2T-E | Human | Esophagus | ESCC | 5.75e-15 | 4.08e-01 | 0.1177 |
56850 | GRIPAP1 | P4T-E | Human | Esophagus | ESCC | 1.23e-16 | 3.37e-01 | 0.1323 |
56850 | GRIPAP1 | P5T-E | Human | Esophagus | ESCC | 1.35e-19 | 1.25e-01 | 0.1327 |
56850 | GRIPAP1 | P8T-E | Human | Esophagus | ESCC | 2.55e-26 | 3.27e-01 | 0.0889 |
56850 | GRIPAP1 | P9T-E | Human | Esophagus | ESCC | 6.51e-06 | 2.22e-01 | 0.1131 |
56850 | GRIPAP1 | P10T-E | Human | Esophagus | ESCC | 4.27e-19 | 1.92e-01 | 0.116 |
56850 | GRIPAP1 | P11T-E | Human | Esophagus | ESCC | 5.96e-17 | 6.35e-01 | 0.1426 |
56850 | GRIPAP1 | P12T-E | Human | Esophagus | ESCC | 2.26e-17 | 1.90e-01 | 0.1122 |
56850 | GRIPAP1 | P15T-E | Human | Esophagus | ESCC | 4.87e-13 | 2.91e-01 | 0.1149 |
56850 | GRIPAP1 | P16T-E | Human | Esophagus | ESCC | 2.99e-14 | 2.76e-01 | 0.1153 |
56850 | GRIPAP1 | P17T-E | Human | Esophagus | ESCC | 6.49e-04 | 2.04e-01 | 0.1278 |
56850 | GRIPAP1 | P20T-E | Human | Esophagus | ESCC | 1.31e-12 | 2.47e-01 | 0.1124 |
56850 | GRIPAP1 | P21T-E | Human | Esophagus | ESCC | 5.15e-16 | 1.74e-01 | 0.1617 |
56850 | GRIPAP1 | P22T-E | Human | Esophagus | ESCC | 4.76e-26 | 4.90e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003238618 | Esophagus | ESCC | regulation of intracellular transport | 243/8552 | 337/18723 | 3.20e-23 | 7.25e-21 | 243 |
GO:0033157110 | Esophagus | ESCC | regulation of intracellular protein transport | 169/8552 | 229/18723 | 3.31e-18 | 3.23e-16 | 169 |
GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
GO:0090150110 | Esophagus | ESCC | establishment of protein localization to membrane | 182/8552 | 260/18723 | 1.27e-15 | 8.19e-14 | 182 |
GO:0072659110 | Esophagus | ESCC | protein localization to plasma membrane | 193/8552 | 284/18723 | 1.95e-14 | 1.03e-12 | 193 |
GO:199077819 | Esophagus | ESCC | protein localization to cell periphery | 217/8552 | 333/18723 | 4.08e-13 | 1.88e-11 | 217 |
GO:009887615 | Esophagus | ESCC | vesicle-mediated transport to the plasma membrane | 99/8552 | 136/18723 | 1.13e-10 | 3.39e-09 | 99 |
GO:190547519 | Esophagus | ESCC | regulation of protein localization to membrane | 117/8552 | 175/18723 | 1.14e-08 | 2.26e-07 | 117 |
GO:003150314 | Esophagus | ESCC | protein-containing complex localization | 139/8552 | 220/18723 | 1.14e-07 | 1.85e-06 | 139 |
GO:190437519 | Esophagus | ESCC | regulation of protein localization to cell periphery | 85/8552 | 125/18723 | 3.63e-07 | 5.06e-06 | 85 |
GO:1903076110 | Esophagus | ESCC | regulation of protein localization to plasma membrane | 72/8552 | 104/18723 | 9.74e-07 | 1.23e-05 | 72 |
GO:006195114 | Esophagus | ESCC | establishment of protein localization to plasma membrane | 44/8552 | 60/18723 | 1.25e-05 | 1.15e-04 | 44 |
GO:00324565 | Esophagus | ESCC | endocytic recycling | 51/8552 | 73/18723 | 2.47e-05 | 2.10e-04 | 51 |
GO:00995324 | Esophagus | ESCC | synaptic vesicle endosomal processing | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
GO:00995635 | Esophagus | ESCC | modification of synaptic structure | 16/8552 | 22/18723 | 9.46e-03 | 3.28e-02 | 16 |
GO:003238621 | Liver | HCC | regulation of intracellular transport | 231/7958 | 337/18723 | 1.99e-22 | 3.40e-20 | 231 |
GO:003315721 | Liver | HCC | regulation of intracellular protein transport | 165/7958 | 229/18723 | 8.37e-20 | 1.15e-17 | 165 |
GO:001619721 | Liver | HCC | endosomal transport | 154/7958 | 230/18723 | 4.74e-14 | 2.95e-12 | 154 |
GO:009015012 | Liver | HCC | establishment of protein localization to membrane | 168/7958 | 260/18723 | 4.07e-13 | 2.13e-11 | 168 |
GO:007265921 | Liver | HCC | protein localization to plasma membrane | 177/7958 | 284/18723 | 1.02e-11 | 4.18e-10 | 177 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRIPAP1 | SNV | Missense_Mutation | rs371110226 | c.293C>G | p.Ala98Gly | p.A98G | Q4V328 | protein_coding | tolerated(0.1) | probably_damaging(0.991) | TCGA-66-2763-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRIPAP1 | SNV | Missense_Mutation | rs782079718 | c.421N>A | p.Gln141Lys | p.Q141K | Q4V328 | protein_coding | deleterious(0.01) | probably_damaging(0.968) | TCGA-66-2778-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
GRIPAP1 | SNV | Missense_Mutation | novel | c.487N>T | p.Gly163Trp | p.G163W | Q4V328 | protein_coding | deleterious(0.01) | possibly_damaging(0.884) | TCGA-68-7757-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GRIPAP1 | SNV | Missense_Mutation | novel | c.1738N>C | p.Asp580His | p.D580H | Q4V328 | protein_coding | deleterious(0.02) | possibly_damaging(0.878) | TCGA-85-7710-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRIPAP1 | SNV | Missense_Mutation | novel | c.1038G>T | p.Glu346Asp | p.E346D | Q4V328 | protein_coding | deleterious(0) | possibly_damaging(0.79) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
GRIPAP1 | SNV | Missense_Mutation | novel | c.62N>T | p.Arg21Leu | p.R21L | Q4V328 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CV-6948-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRIPAP1 | SNV | Missense_Mutation | rs782108488 | c.1132G>A | p.Glu378Lys | p.E378K | Q4V328 | protein_coding | tolerated(0.05) | probably_damaging(0.993) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRIPAP1 | SNV | Missense_Mutation | novel | c.2294C>G | p.Ala765Gly | p.A765G | Q4V328 | protein_coding | tolerated(0.49) | benign(0.009) | TCGA-CH-5748-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
GRIPAP1 | SNV | Missense_Mutation | c.542N>A | p.Pro181His | p.P181H | Q4V328 | protein_coding | deleterious(0.01) | possibly_damaging(0.828) | TCGA-EJ-7125-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
GRIPAP1 | SNV | Missense_Mutation | c.1871N>A | p.Arg624Gln | p.R624Q | Q4V328 | protein_coding | deleterious(0.05) | benign(0.018) | TCGA-BR-4267-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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