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Gene: GGNBP2 |
Gene summary for GGNBP2 |
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Gene information | Species | Human | Gene symbol | GGNBP2 | Gene ID | 79893 |
Gene name | gametogenetin binding protein 2 | |
Gene Alias | DIF-3 | |
Cytomap | 17q12 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9H3C7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79893 | GGNBP2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.21e-09 | -5.63e-01 | 0.0155 |
79893 | GGNBP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.07e-05 | 3.78e-01 | -0.1954 |
79893 | GGNBP2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.93e-06 | -5.34e-01 | 0.096 |
79893 | GGNBP2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.31e-02 | -4.46e-01 | 0.0338 |
79893 | GGNBP2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.69e-03 | -2.65e-01 | 0.0674 |
79893 | GGNBP2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.42e-03 | -2.80e-01 | 0.294 |
79893 | GGNBP2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.00e-02 | -3.18e-01 | 0.3859 |
79893 | GGNBP2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.08e-07 | -4.13e-01 | 0.3005 |
79893 | GGNBP2 | A002-C-010 | Human | Colorectum | FAP | 2.91e-07 | -3.14e-01 | 0.242 |
79893 | GGNBP2 | A001-C-207 | Human | Colorectum | FAP | 2.27e-02 | -2.41e-01 | 0.1278 |
79893 | GGNBP2 | A015-C-203 | Human | Colorectum | FAP | 9.77e-29 | -1.94e-01 | -0.1294 |
79893 | GGNBP2 | A015-C-204 | Human | Colorectum | FAP | 4.08e-05 | 2.71e-02 | -0.0228 |
79893 | GGNBP2 | A014-C-040 | Human | Colorectum | FAP | 3.04e-03 | -7.85e-02 | -0.1184 |
79893 | GGNBP2 | A002-C-201 | Human | Colorectum | FAP | 5.50e-10 | -2.23e-01 | 0.0324 |
79893 | GGNBP2 | A002-C-203 | Human | Colorectum | FAP | 2.86e-05 | -2.31e-01 | 0.2786 |
79893 | GGNBP2 | A001-C-119 | Human | Colorectum | FAP | 3.47e-13 | 4.14e-01 | -0.1557 |
79893 | GGNBP2 | A001-C-108 | Human | Colorectum | FAP | 5.72e-17 | -9.81e-02 | -0.0272 |
79893 | GGNBP2 | A002-C-205 | Human | Colorectum | FAP | 2.92e-23 | 1.57e-01 | -0.1236 |
79893 | GGNBP2 | A001-C-104 | Human | Colorectum | FAP | 1.31e-06 | -5.90e-02 | 0.0184 |
79893 | GGNBP2 | A015-C-005 | Human | Colorectum | FAP | 3.80e-03 | -1.94e-01 | -0.0336 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010563 | Colorectum | AD | negative regulation of phosphorus metabolic process | 130/3918 | 442/18723 | 1.26e-05 | 2.76e-04 | 130 |
GO:0045936 | Colorectum | AD | negative regulation of phosphate metabolic process | 129/3918 | 441/18723 | 1.81e-05 | 3.76e-04 | 129 |
GO:0051348 | Colorectum | AD | negative regulation of transferase activity | 85/3918 | 268/18723 | 2.07e-05 | 4.19e-04 | 85 |
GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
GO:0001890 | Colorectum | AD | placenta development | 51/3918 | 144/18723 | 3.99e-05 | 7.16e-04 | 51 |
GO:0001892 | Colorectum | AD | embryonic placenta development | 33/3918 | 82/18723 | 5.30e-05 | 9.01e-04 | 33 |
GO:0042326 | Colorectum | AD | negative regulation of phosphorylation | 112/3918 | 385/18723 | 8.02e-05 | 1.27e-03 | 112 |
GO:0001933 | Colorectum | AD | negative regulation of protein phosphorylation | 101/3918 | 342/18723 | 9.39e-05 | 1.42e-03 | 101 |
GO:0006469 | Colorectum | AD | negative regulation of protein kinase activity | 65/3918 | 212/18723 | 5.21e-04 | 5.62e-03 | 65 |
GO:0033673 | Colorectum | AD | negative regulation of kinase activity | 71/3918 | 237/18723 | 6.18e-04 | 6.47e-03 | 71 |
GO:0060711 | Colorectum | AD | labyrinthine layer development | 19/3918 | 44/18723 | 7.13e-04 | 7.21e-03 | 19 |
GO:0061458 | Colorectum | AD | reproductive system development | 116/3918 | 427/18723 | 1.11e-03 | 1.01e-02 | 116 |
GO:0018105 | Colorectum | AD | peptidyl-serine phosphorylation | 88/3918 | 315/18723 | 1.73e-03 | 1.43e-02 | 88 |
GO:0048608 | Colorectum | AD | reproductive structure development | 114/3918 | 424/18723 | 1.78e-03 | 1.47e-02 | 114 |
GO:0018209 | Colorectum | AD | peptidyl-serine modification | 92/3918 | 338/18723 | 3.19e-03 | 2.36e-02 | 92 |
GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
GO:0060716 | Colorectum | AD | labyrinthine layer blood vessel development | 9/3918 | 18/18723 | 5.82e-03 | 3.67e-02 | 9 |
GO:0061099 | Colorectum | AD | negative regulation of protein tyrosine kinase activity | 13/3918 | 31/18723 | 6.53e-03 | 4.06e-02 | 13 |
GO:00018902 | Colorectum | MSS | placenta development | 51/3467 | 144/18723 | 1.10e-06 | 3.77e-05 | 51 |
GO:00513482 | Colorectum | MSS | negative regulation of transferase activity | 80/3467 | 268/18723 | 4.06e-06 | 1.17e-04 | 80 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GGNBP2 | SNV | Missense_Mutation | novel | c.357N>T | p.Lys119Asn | p.K119N | Q9H3C7 | protein_coding | tolerated(0.56) | benign(0) | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
GGNBP2 | SNV | Missense_Mutation | novel | c.1120N>T | p.Arg374Cys | p.R374C | Q9H3C7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
GGNBP2 | SNV | Missense_Mutation | novel | c.1487N>G | p.Glu496Gly | p.E496G | Q9H3C7 | protein_coding | deleterious(0.04) | benign(0.366) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
GGNBP2 | SNV | Missense_Mutation | novel | c.1001N>T | p.Ala334Val | p.A334V | Q9H3C7 | protein_coding | deleterious(0) | possibly_damaging(0.88) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
GGNBP2 | SNV | Missense_Mutation | novel | c.656N>A | p.Cys219Tyr | p.C219Y | Q9H3C7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VQ-A8PB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR |
GGNBP2 | insertion | Frame_Shift_Ins | novel | c.1151_1152insGT | p.Asp388ValfsTer15 | p.D388Vfs*15 | Q9H3C7 | protein_coding | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD | ||
GGNBP2 | deletion | Frame_Shift_Del | novel | c.1148delA | p.Asn383IlefsTer19 | p.N383Ifs*19 | Q9H3C7 | protein_coding | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | ||
GGNBP2 | insertion | Frame_Shift_Ins | novel | c.1167_1168insGGTCAGAA | p.Pro390GlyfsTer15 | p.P390Gfs*15 | Q9H3C7 | protein_coding | TCGA-EL-A3ZR-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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