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Gene: EXOC3 |
Gene summary for EXOC3 |
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Gene information | Species | Human | Gene symbol | EXOC3 | Gene ID | 11336 |
Gene name | exocyst complex component 3 | |
Gene Alias | SEC6 | |
Cytomap | 5p15.33 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024QYZ6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11336 | EXOC3 | Tumor | Human | Cervix | CC | 1.93e-14 | 5.20e-01 | 0.1241 |
11336 | EXOC3 | sample3 | Human | Cervix | CC | 1.87e-28 | 5.13e-01 | 0.1387 |
11336 | EXOC3 | L1 | Human | Cervix | CC | 1.96e-08 | 5.37e-01 | 0.0802 |
11336 | EXOC3 | T3 | Human | Cervix | CC | 2.65e-12 | 4.67e-01 | 0.1389 |
11336 | EXOC3 | LZE4T | Human | Esophagus | ESCC | 7.33e-07 | 2.14e-01 | 0.0811 |
11336 | EXOC3 | LZE8T | Human | Esophagus | ESCC | 3.91e-07 | 2.82e-01 | 0.067 |
11336 | EXOC3 | LZE20T | Human | Esophagus | ESCC | 2.60e-05 | 2.57e-01 | 0.0662 |
11336 | EXOC3 | LZE22T | Human | Esophagus | ESCC | 6.13e-05 | 2.77e-01 | 0.068 |
11336 | EXOC3 | LZE24T | Human | Esophagus | ESCC | 1.94e-06 | 1.61e-01 | 0.0596 |
11336 | EXOC3 | LZE21T | Human | Esophagus | ESCC | 9.50e-04 | 2.59e-01 | 0.0655 |
11336 | EXOC3 | LZE6T | Human | Esophagus | ESCC | 2.94e-04 | 2.11e-01 | 0.0845 |
11336 | EXOC3 | P1T-E | Human | Esophagus | ESCC | 8.47e-12 | 3.78e-01 | 0.0875 |
11336 | EXOC3 | P2T-E | Human | Esophagus | ESCC | 1.79e-10 | 1.83e-01 | 0.1177 |
11336 | EXOC3 | P4T-E | Human | Esophagus | ESCC | 5.48e-19 | 4.80e-01 | 0.1323 |
11336 | EXOC3 | P5T-E | Human | Esophagus | ESCC | 2.90e-15 | 1.70e-01 | 0.1327 |
11336 | EXOC3 | P8T-E | Human | Esophagus | ESCC | 8.80e-17 | 4.14e-01 | 0.0889 |
11336 | EXOC3 | P9T-E | Human | Esophagus | ESCC | 4.73e-12 | 2.82e-01 | 0.1131 |
11336 | EXOC3 | P10T-E | Human | Esophagus | ESCC | 9.40e-25 | 4.38e-01 | 0.116 |
11336 | EXOC3 | P11T-E | Human | Esophagus | ESCC | 2.50e-07 | 2.50e-01 | 0.1426 |
11336 | EXOC3 | P12T-E | Human | Esophagus | ESCC | 4.39e-18 | 2.44e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00068873 | Cervix | CC | exocytosis | 59/2311 | 352/18723 | 8.74e-03 | 4.48e-02 | 59 |
GO:003150314 | Esophagus | ESCC | protein-containing complex localization | 139/8552 | 220/18723 | 1.14e-07 | 1.85e-06 | 139 |
GO:00315031 | Liver | HCC | protein-containing complex localization | 129/7958 | 220/18723 | 9.38e-07 | 1.42e-05 | 129 |
GO:0034629 | Liver | HCC | cellular protein-containing complex localization | 17/7958 | 22/18723 | 9.84e-04 | 5.70e-03 | 17 |
GO:00315032 | Lung | IAC | protein-containing complex localization | 42/2061 | 220/18723 | 2.60e-04 | 4.32e-03 | 42 |
GO:00315034 | Oral cavity | OSCC | protein-containing complex localization | 123/7305 | 220/18723 | 2.54e-07 | 4.00e-06 | 123 |
GO:003150313 | Oral cavity | LP | protein-containing complex localization | 82/4623 | 220/18723 | 2.08e-05 | 3.44e-04 | 82 |
GO:003150315 | Skin | cSCC | protein-containing complex localization | 95/4864 | 220/18723 | 2.00e-08 | 5.82e-07 | 95 |
GO:00315037 | Thyroid | PTC | protein-containing complex localization | 107/5968 | 220/18723 | 1.47e-07 | 2.82e-06 | 107 |
GO:003150316 | Thyroid | ATC | protein-containing complex localization | 108/6293 | 220/18723 | 1.33e-06 | 1.69e-05 | 108 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EXOC3 | SNV | Missense_Mutation | novel | c.1183N>A | p.Leu395Met | p.L395M | O60645 | protein_coding | tolerated(0.29) | possibly_damaging(0.617) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
EXOC3 | SNV | Missense_Mutation | c.1766N>T | p.Pro589Leu | p.P589L | O60645 | protein_coding | tolerated(0.11) | benign(0.005) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
EXOC3 | SNV | Missense_Mutation | novel | c.2098N>T | p.Arg700Cys | p.R700C | O60645 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
EXOC3 | SNV | Missense_Mutation | c.751N>G | p.Ile251Val | p.I251V | O60645 | protein_coding | tolerated(1) | benign(0.001) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EXOC3 | SNV | Missense_Mutation | novel | c.604N>A | p.Val202Ile | p.V202I | O60645 | protein_coding | tolerated(0.22) | possibly_damaging(0.85) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
EXOC3 | deletion | In_Frame_Del | novel | c.2009_2014delNNNNNN | p.Asp670_Ser672delinsAla | p.D670_S672delinsA | O60645 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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