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Gene: ESRP1 |
Gene summary for ESRP1 |
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Gene information | Species | Human | Gene symbol | ESRP1 | Gene ID | 54845 |
Gene name | epithelial splicing regulatory protein 1 | |
Gene Alias | DFNB109 | |
Cytomap | 8q22.1 | |
Gene Type | protein-coding | GO ID | GO:0001708 | UniProtAcc | Q6NXG1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54845 | ESRP1 | CA_HPV_1 | Human | Cervix | CC | 2.62e-02 | -1.32e-01 | 0.0264 |
54845 | ESRP1 | CCI_1 | Human | Cervix | CC | 2.17e-11 | 9.93e-01 | 0.528 |
54845 | ESRP1 | CCI_2 | Human | Cervix | CC | 3.78e-13 | 1.36e+00 | 0.5249 |
54845 | ESRP1 | CCI_3 | Human | Cervix | CC | 5.29e-07 | 6.97e-01 | 0.516 |
54845 | ESRP1 | sample3 | Human | Cervix | CC | 5.18e-08 | 2.96e-01 | 0.1387 |
54845 | ESRP1 | T3 | Human | Cervix | CC | 8.52e-11 | 3.49e-01 | 0.1389 |
54845 | ESRP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.71e-11 | -4.85e-01 | 0.0155 |
54845 | ESRP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.61e-17 | 8.03e-01 | -0.1954 |
54845 | ESRP1 | HTA11_411_2000001011 | Human | Colorectum | SER | 7.19e-04 | 6.69e-01 | -0.2602 |
54845 | ESRP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.84e-05 | -4.50e-01 | 0.096 |
54845 | ESRP1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 4.28e-02 | -5.80e-01 | 0.0451 |
54845 | ESRP1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 8.04e-06 | -5.26e-01 | 0.2585 |
54845 | ESRP1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.21e-16 | -5.98e-01 | 0.3005 |
54845 | ESRP1 | F007 | Human | Colorectum | FAP | 2.44e-07 | -5.14e-01 | 0.1176 |
54845 | ESRP1 | A001-C-207 | Human | Colorectum | FAP | 1.11e-16 | -6.39e-01 | 0.1278 |
54845 | ESRP1 | A015-C-203 | Human | Colorectum | FAP | 8.18e-37 | -6.16e-01 | -0.1294 |
54845 | ESRP1 | A015-C-204 | Human | Colorectum | FAP | 6.58e-12 | -4.73e-01 | -0.0228 |
54845 | ESRP1 | A014-C-040 | Human | Colorectum | FAP | 8.16e-10 | -6.34e-01 | -0.1184 |
54845 | ESRP1 | A002-C-201 | Human | Colorectum | FAP | 6.20e-29 | -6.92e-01 | 0.0324 |
54845 | ESRP1 | A002-C-203 | Human | Colorectum | FAP | 1.08e-09 | -4.18e-01 | 0.2786 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00085446 | Cervix | CC | epidermis development | 83/2311 | 324/18723 | 3.91e-11 | 8.54e-09 | 83 |
GO:00099137 | Cervix | CC | epidermal cell differentiation | 53/2311 | 202/18723 | 5.48e-08 | 3.25e-06 | 53 |
GO:004348410 | Cervix | CC | regulation of RNA splicing | 42/2311 | 148/18723 | 1.25e-07 | 6.24e-06 | 42 |
GO:00456822 | Cervix | CC | regulation of epidermis development | 22/2311 | 65/18723 | 5.56e-06 | 1.38e-04 | 22 |
GO:00456042 | Cervix | CC | regulation of epidermal cell differentiation | 20/2311 | 58/18723 | 1.07e-05 | 2.33e-04 | 20 |
GO:00308563 | Cervix | CC | regulation of epithelial cell differentiation | 36/2311 | 154/18723 | 1.02e-04 | 1.31e-03 | 36 |
GO:000838010 | Cervix | CC | RNA splicing | 76/2311 | 434/18723 | 9.79e-04 | 8.19e-03 | 76 |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0043484 | Colorectum | AD | regulation of RNA splicing | 70/3918 | 148/18723 | 6.47e-13 | 1.16e-10 | 70 |
GO:0035315 | Colorectum | AD | hair cell differentiation | 21/3918 | 47/18723 | 2.14e-04 | 2.82e-03 | 21 |
GO:0042491 | Colorectum | AD | inner ear auditory receptor cell differentiation | 17/3918 | 38/18723 | 8.26e-04 | 8.13e-03 | 17 |
GO:0042490 | Colorectum | AD | mechanoreceptor differentiation | 24/3918 | 67/18723 | 3.48e-03 | 2.52e-02 | 24 |
GO:0009913 | Colorectum | AD | epidermal cell differentiation | 58/3918 | 202/18723 | 5.16e-03 | 3.42e-02 | 58 |
GO:0008544 | Colorectum | AD | epidermis development | 87/3918 | 324/18723 | 5.99e-03 | 3.76e-02 | 87 |
GO:00083801 | Colorectum | SER | RNA splicing | 123/2897 | 434/18723 | 3.84e-12 | 8.41e-10 | 123 |
GO:00434841 | Colorectum | SER | regulation of RNA splicing | 49/2897 | 148/18723 | 7.02e-08 | 4.49e-06 | 49 |
GO:00353151 | Colorectum | SER | hair cell differentiation | 15/2897 | 47/18723 | 3.68e-03 | 3.07e-02 | 15 |
GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
GO:00434842 | Colorectum | MSS | regulation of RNA splicing | 66/3467 | 148/18723 | 2.44e-13 | 5.25e-11 | 66 |
GO:00353152 | Colorectum | MSS | hair cell differentiation | 19/3467 | 47/18723 | 3.88e-04 | 4.86e-03 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ESRP1 | TH17 | Skin | ADJ | DSP,KRT10,KRT1, etc. | 7.98e-03 | ![]() |
ESRP1 | CD8TRM | Skin | SCCIS | DSP,KRT10,KRT1, etc. | 2.60e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ESRP1 | SNV | Missense_Mutation | novel | c.71G>C | p.Gly24Ala | p.G24A | Q6NXG1 | protein_coding | deleterious(0) | possibly_damaging(0.908) | TCGA-VQ-AA6B-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | CR |
ESRP1 | insertion | Frame_Shift_Ins | novel | c.1394_1395insG | p.Glu467GlyfsTer44 | p.E467Gfs*44 | Q6NXG1 | protein_coding | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ESRP1 | SNV | Missense_Mutation | c.1315N>T | p.Pro439Ser | p.P439S | Q6NXG1 | protein_coding | deleterious(0.02) | benign(0.04) | TCGA-H2-A2K9-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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