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Gene: EHMT2 |
Gene summary for EHMT2 |
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Gene information | Species | Human | Gene symbol | EHMT2 | Gene ID | 10919 |
Gene name | euchromatic histone lysine methyltransferase 2 | |
Gene Alias | BAT8 | |
Cytomap | 6p21.33 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A2ABF8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10919 | EHMT2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.28e-05 | 3.32e-01 | -0.1808 |
10919 | EHMT2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.40e-07 | 4.16e-01 | -0.1954 |
10919 | EHMT2 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.33e-15 | 5.82e-01 | -0.1464 |
10919 | EHMT2 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.84e-10 | 4.30e-01 | -0.1001 |
10919 | EHMT2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.62e-06 | 4.07e-01 | -0.059 |
10919 | EHMT2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.01e-04 | 2.55e-01 | 0.0674 |
10919 | EHMT2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.34e-03 | 3.67e-01 | 0.281 |
10919 | EHMT2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.69e-05 | 3.50e-01 | 0.3859 |
10919 | EHMT2 | A015-C-104 | Human | Colorectum | FAP | 2.37e-03 | 1.31e-01 | -0.1899 |
10919 | EHMT2 | LZE4T | Human | Esophagus | ESCC | 2.33e-08 | 2.29e-01 | 0.0811 |
10919 | EHMT2 | LZE7T | Human | Esophagus | ESCC | 1.11e-12 | 3.64e-01 | 0.0667 |
10919 | EHMT2 | LZE20T | Human | Esophagus | ESCC | 1.07e-09 | 2.71e-01 | 0.0662 |
10919 | EHMT2 | LZE22D1 | Human | Esophagus | HGIN | 2.08e-03 | 2.04e-01 | 0.0595 |
10919 | EHMT2 | LZE22T | Human | Esophagus | ESCC | 6.37e-11 | 5.79e-01 | 0.068 |
10919 | EHMT2 | LZE24T | Human | Esophagus | ESCC | 6.07e-15 | 4.44e-01 | 0.0596 |
10919 | EHMT2 | LZE6T | Human | Esophagus | ESCC | 3.18e-03 | 2.45e-01 | 0.0845 |
10919 | EHMT2 | P1T-E | Human | Esophagus | ESCC | 5.29e-10 | 5.19e-01 | 0.0875 |
10919 | EHMT2 | P2T-E | Human | Esophagus | ESCC | 1.74e-67 | 9.25e-01 | 0.1177 |
10919 | EHMT2 | P4T-E | Human | Esophagus | ESCC | 1.01e-35 | 6.99e-01 | 0.1323 |
10919 | EHMT2 | P5T-E | Human | Esophagus | ESCC | 4.95e-18 | 4.08e-01 | 0.1327 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009895 | Colorectum | AD | negative regulation of catabolic process | 124/3918 | 320/18723 | 1.66e-13 | 3.35e-11 | 124 |
GO:0031330 | Colorectum | AD | negative regulation of cellular catabolic process | 104/3918 | 262/18723 | 2.66e-12 | 3.96e-10 | 104 |
GO:0010506 | Colorectum | AD | regulation of autophagy | 111/3918 | 317/18723 | 3.57e-09 | 2.35e-07 | 111 |
GO:0016236 | Colorectum | AD | macroautophagy | 103/3918 | 291/18723 | 6.76e-09 | 4.15e-07 | 103 |
GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
GO:0009636 | Colorectum | AD | response to toxic substance | 88/3918 | 262/18723 | 1.12e-06 | 3.72e-05 | 88 |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:0016241 | Colorectum | AD | regulation of macroautophagy | 50/3918 | 141/18723 | 4.55e-05 | 7.92e-04 | 50 |
GO:0042594 | Colorectum | AD | response to starvation | 63/3918 | 197/18723 | 1.77e-04 | 2.38e-03 | 63 |
GO:0071496 | Colorectum | AD | cellular response to external stimulus | 94/3918 | 320/18723 | 1.98e-04 | 2.64e-03 | 94 |
GO:0009410 | Colorectum | AD | response to xenobiotic stimulus | 128/3918 | 462/18723 | 2.69e-04 | 3.31e-03 | 128 |
GO:0009267 | Colorectum | AD | cellular response to starvation | 51/3918 | 156/18723 | 3.90e-04 | 4.44e-03 | 51 |
GO:0010507 | Colorectum | AD | negative regulation of autophagy | 31/3918 | 85/18723 | 6.91e-04 | 7.05e-03 | 31 |
GO:0031668 | Colorectum | AD | cellular response to extracellular stimulus | 71/3918 | 246/18723 | 1.86e-03 | 1.52e-02 | 71 |
GO:0031669 | Colorectum | AD | cellular response to nutrient levels | 63/3918 | 215/18723 | 2.19e-03 | 1.73e-02 | 63 |
GO:0097305 | Colorectum | AD | response to alcohol | 71/3918 | 253/18723 | 4.01e-03 | 2.80e-02 | 71 |
GO:0007033 | Colorectum | AD | vacuole organization | 53/3918 | 180/18723 | 4.18e-03 | 2.89e-02 | 53 |
GO:0031056 | Colorectum | AD | regulation of histone modification | 45/3918 | 152/18723 | 7.05e-03 | 4.31e-02 | 45 |
GO:00162361 | Colorectum | SER | macroautophagy | 79/2897 | 291/18723 | 1.97e-07 | 1.10e-05 | 79 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04211 | Colorectum | AD | Longevity regulating pathway | 33/2092 | 89/8465 | 6.15e-03 | 2.68e-02 | 1.71e-02 | 33 |
hsa042111 | Colorectum | AD | Longevity regulating pathway | 33/2092 | 89/8465 | 6.15e-03 | 2.68e-02 | 1.71e-02 | 33 |
hsa042112 | Colorectum | MSS | Longevity regulating pathway | 33/1875 | 89/8465 | 9.33e-04 | 5.58e-03 | 3.42e-03 | 33 |
hsa003102 | Colorectum | MSS | Lysine degradation | 24/1875 | 63/8465 | 2.94e-03 | 1.39e-02 | 8.50e-03 | 24 |
hsa042113 | Colorectum | MSS | Longevity regulating pathway | 33/1875 | 89/8465 | 9.33e-04 | 5.58e-03 | 3.42e-03 | 33 |
hsa003103 | Colorectum | MSS | Lysine degradation | 24/1875 | 63/8465 | 2.94e-03 | 1.39e-02 | 8.50e-03 | 24 |
hsa042114 | Colorectum | FAP | Longevity regulating pathway | 27/1404 | 89/8465 | 8.82e-04 | 5.20e-03 | 3.16e-03 | 27 |
hsa042115 | Colorectum | FAP | Longevity regulating pathway | 27/1404 | 89/8465 | 8.82e-04 | 5.20e-03 | 3.16e-03 | 27 |
hsa0421114 | Esophagus | ESCC | Longevity regulating pathway | 58/4205 | 89/8465 | 2.19e-03 | 6.16e-03 | 3.16e-03 | 58 |
hsa0031010 | Esophagus | ESCC | Lysine degradation | 41/4205 | 63/8465 | 9.63e-03 | 2.27e-02 | 1.16e-02 | 41 |
hsa0421115 | Esophagus | ESCC | Longevity regulating pathway | 58/4205 | 89/8465 | 2.19e-03 | 6.16e-03 | 3.16e-03 | 58 |
hsa0031013 | Esophagus | ESCC | Lysine degradation | 41/4205 | 63/8465 | 9.63e-03 | 2.27e-02 | 1.16e-02 | 41 |
hsa0031021 | Liver | Cirrhotic | Lysine degradation | 29/2530 | 63/8465 | 4.81e-03 | 1.74e-02 | 1.07e-02 | 29 |
hsa042118 | Liver | Cirrhotic | Longevity regulating pathway | 37/2530 | 89/8465 | 1.22e-02 | 3.89e-02 | 2.40e-02 | 37 |
hsa0031031 | Liver | Cirrhotic | Lysine degradation | 29/2530 | 63/8465 | 4.81e-03 | 1.74e-02 | 1.07e-02 | 29 |
hsa0421111 | Liver | Cirrhotic | Longevity regulating pathway | 37/2530 | 89/8465 | 1.22e-02 | 3.89e-02 | 2.40e-02 | 37 |
hsa0031041 | Liver | HCC | Lysine degradation | 47/4020 | 63/8465 | 1.02e-05 | 7.58e-05 | 4.22e-05 | 47 |
hsa0421121 | Liver | HCC | Longevity regulating pathway | 61/4020 | 89/8465 | 4.46e-05 | 2.37e-04 | 1.32e-04 | 61 |
hsa0031051 | Liver | HCC | Lysine degradation | 47/4020 | 63/8465 | 1.02e-05 | 7.58e-05 | 4.22e-05 | 47 |
hsa0421131 | Liver | HCC | Longevity regulating pathway | 61/4020 | 89/8465 | 4.46e-05 | 2.37e-04 | 1.32e-04 | 61 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EHMT2 | SNV | Missense_Mutation | novel | c.1451C>T | p.Ala484Val | p.A484V | protein_coding | tolerated(0.16) | benign(0.073) | TCGA-IQ-A61G-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD | |
EHMT2 | SNV | Missense_Mutation | novel | c.307C>T | p.Arg103Cys | p.R103C | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-QK-A6IG-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
EHMT2 | SNV | Missense_Mutation | c.3123C>A | p.Asn1041Lys | p.N1041K | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EJ-5498-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | ||
EHMT2 | SNV | Missense_Mutation | rs143327875 | c.2750G>A | p.Arg917His | p.R917H | protein_coding | tolerated(0.24) | benign(0.034) | TCGA-V1-A9O7-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | PD | |
EHMT2 | SNV | Missense_Mutation | novel | c.3128N>T | p.Ala1043Val | p.A1043V | protein_coding | tolerated(0.11) | possibly_damaging(0.673) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
EHMT2 | SNV | Missense_Mutation | c.2786N>T | p.Lys929Met | p.K929M | protein_coding | deleterious(0.01) | probably_damaging(0.94) | TCGA-BR-4369-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
EHMT2 | SNV | Missense_Mutation | c.3473N>A | p.Arg1158His | p.R1158H | protein_coding | tolerated(0.18) | benign(0.109) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
EHMT2 | SNV | Missense_Mutation | c.2924N>G | p.Tyr975Cys | p.Y975C | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | ||
EHMT2 | SNV | Missense_Mutation | rs760598540 | c.3503G>A | p.Arg1168Gln | p.R1168Q | protein_coding | tolerated(0.67) | benign(0.003) | TCGA-D7-8578-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
EHMT2 | SNV | Missense_Mutation | c.3197N>G | p.Tyr1066Cys | p.Y1066C | protein_coding | deleterious(0.02) | benign(0.423) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10919 | EHMT2 | METHYL TRANSFERASE, ENZYME, DRUGGABLE GENOME | LISINOPRIL HYDRATE | LISINOPRIL HYDRATE | ||
10919 | EHMT2 | METHYL TRANSFERASE, ENZYME, DRUGGABLE GENOME | DYCLONINE | DYCLONINE | ||
10919 | EHMT2 | METHYL TRANSFERASE, ENZYME, DRUGGABLE GENOME | SJ000114950 | CHEMBL606456 | ||
10919 | EHMT2 | METHYL TRANSFERASE, ENZYME, DRUGGABLE GENOME | WIN-552122 | WIN-552122 | ||
10919 | EHMT2 | METHYL TRANSFERASE, ENZYME, DRUGGABLE GENOME | HISTAMINE | HISTAMINE | ||
10919 | EHMT2 | METHYL TRANSFERASE, ENZYME, DRUGGABLE GENOME | N-(3-METHOXYPHENYL)ANTHRANILIC ACID | CHEMBL1328677 | ||
10919 | EHMT2 | METHYL TRANSFERASE, ENZYME, DRUGGABLE GENOME | MEDRONIC ACID | MEDRONIC ACID | ||
10919 | EHMT2 | METHYL TRANSFERASE, ENZYME, DRUGGABLE GENOME | SJ000014858 | CHEMBL591628 | ||
10919 | EHMT2 | METHYL TRANSFERASE, ENZYME, DRUGGABLE GENOME | TELMISARTAN | TELMISARTAN | ||
10919 | EHMT2 | METHYL TRANSFERASE, ENZYME, DRUGGABLE GENOME | GNF-PF-989 | CHEMBL583150 |
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