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Gene: DPP8 |
Gene summary for DPP8 |
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Gene information | Species | Human | Gene symbol | DPP8 | Gene ID | 54878 |
Gene name | dipeptidyl peptidase 8 | |
Gene Alias | DP8 | |
Cytomap | 15q22.31 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | A0A024R5Z6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54878 | DPP8 | LZE4T | Human | Esophagus | ESCC | 5.55e-09 | 1.93e-01 | 0.0811 |
54878 | DPP8 | LZE7T | Human | Esophagus | ESCC | 6.75e-08 | 4.29e-01 | 0.0667 |
54878 | DPP8 | LZE20T | Human | Esophagus | ESCC | 8.07e-06 | 1.63e-01 | 0.0662 |
54878 | DPP8 | LZE24T | Human | Esophagus | ESCC | 5.95e-07 | 2.08e-01 | 0.0596 |
54878 | DPP8 | P1T-E | Human | Esophagus | ESCC | 4.70e-07 | 3.54e-01 | 0.0875 |
54878 | DPP8 | P2T-E | Human | Esophagus | ESCC | 6.65e-14 | 3.17e-01 | 0.1177 |
54878 | DPP8 | P4T-E | Human | Esophagus | ESCC | 9.16e-18 | 3.32e-01 | 0.1323 |
54878 | DPP8 | P5T-E | Human | Esophagus | ESCC | 2.21e-07 | 1.29e-01 | 0.1327 |
54878 | DPP8 | P8T-E | Human | Esophagus | ESCC | 1.56e-22 | 3.18e-01 | 0.0889 |
54878 | DPP8 | P9T-E | Human | Esophagus | ESCC | 3.82e-12 | 2.43e-01 | 0.1131 |
54878 | DPP8 | P10T-E | Human | Esophagus | ESCC | 3.56e-17 | 3.39e-01 | 0.116 |
54878 | DPP8 | P11T-E | Human | Esophagus | ESCC | 2.41e-09 | 2.45e-01 | 0.1426 |
54878 | DPP8 | P12T-E | Human | Esophagus | ESCC | 6.88e-13 | 3.62e-01 | 0.1122 |
54878 | DPP8 | P15T-E | Human | Esophagus | ESCC | 1.53e-16 | 4.13e-01 | 0.1149 |
54878 | DPP8 | P16T-E | Human | Esophagus | ESCC | 4.07e-13 | 3.69e-01 | 0.1153 |
54878 | DPP8 | P19T-E | Human | Esophagus | ESCC | 3.36e-04 | 5.71e-01 | 0.1662 |
54878 | DPP8 | P20T-E | Human | Esophagus | ESCC | 7.95e-12 | 2.70e-01 | 0.1124 |
54878 | DPP8 | P21T-E | Human | Esophagus | ESCC | 1.30e-08 | 1.49e-01 | 0.1617 |
54878 | DPP8 | P22T-E | Human | Esophagus | ESCC | 1.72e-17 | 1.45e-01 | 0.1236 |
54878 | DPP8 | P23T-E | Human | Esophagus | ESCC | 5.42e-16 | 3.54e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DPP8 | SNV | Missense_Mutation | c.2575N>T | p.Ile859Phe | p.I859F | Q6V1X1 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-BR-8289-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
DPP8 | SNV | Missense_Mutation | rs753995054 | c.547N>A | p.Gly183Ser | p.G183S | Q6V1X1 | protein_coding | tolerated(1) | benign(0.153) | TCGA-D7-A4YT-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
DPP8 | SNV | Missense_Mutation | novel | c.1963N>A | p.Asp655Asn | p.D655N | Q6V1X1 | protein_coding | tolerated(1) | benign(0) | TCGA-D7-A6EX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DPP8 | SNV | Missense_Mutation | novel | c.661N>A | p.Cys221Ser | p.C221S | Q6V1X1 | protein_coding | tolerated(0.12) | possibly_damaging(0.817) | TCGA-IN-A6RN-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DPP8 | insertion | Frame_Shift_Ins | novel | c.1372_1373insC | p.Gln458ProfsTer8 | p.Q458Pfs*8 | Q6V1X1 | protein_coding | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD | ||
DPP8 | SNV | Missense_Mutation | c.2504N>C | p.Asn835Thr | p.N835T | Q6V1X1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DJ-A4V5-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DPP8 | insertion | Frame_Shift_Ins | novel | c.1882_1883insTCAAAATCTTAAA | p.Pro628LeufsTer6 | p.P628Lfs*6 | Q6V1X1 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
54878 | DPP8 | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 178103150 | ||
54878 | DPP8 | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 252166751 | ||
54878 | DPP8 | DRUGGABLE GENOME, PROTEASE, ENZYME | Thiomorpholine derivative 1 | |||
54878 | DPP8 | DRUGGABLE GENOME, PROTEASE, ENZYME | Thiomorpholine derivative 2 | |||
54878 | DPP8 | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 252166752 | ||
54878 | DPP8 | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 363894200 | TENELIGLIPTIN | |
54878 | DPP8 | DRUGGABLE GENOME, PROTEASE, ENZYME | Talabostat | TALABOSTAT | ||
54878 | DPP8 | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 363894187 | ||
54878 | DPP8 | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 363894186 | TALABOSTAT |
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