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Gene: DCHS1 |
Gene summary for DCHS1 |
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Gene information | Species | Human | Gene symbol | DCHS1 | Gene ID | 8642 |
Gene name | dachsous cadherin-related 1 | |
Gene Alias | CDH19 | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q96JQ0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8642 | DCHS1 | HCC1_Meng | Human | Liver | HCC | 1.54e-02 | -3.29e-03 | 0.0246 |
8642 | DCHS1 | S014 | Human | Liver | HCC | 2.30e-15 | 5.29e-01 | 0.2254 |
8642 | DCHS1 | S015 | Human | Liver | HCC | 1.49e-10 | 4.73e-01 | 0.2375 |
8642 | DCHS1 | S016 | Human | Liver | HCC | 1.17e-23 | 6.01e-01 | 0.2243 |
8642 | DCHS1 | ATC13 | Human | Thyroid | ATC | 2.19e-27 | 5.32e-01 | 0.34 |
8642 | DCHS1 | ATC5 | Human | Thyroid | ATC | 1.84e-32 | 5.76e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007265921 | Liver | HCC | protein localization to plasma membrane | 177/7958 | 284/18723 | 1.02e-11 | 4.18e-10 | 177 |
GO:199077821 | Liver | HCC | protein localization to cell periphery | 200/7958 | 333/18723 | 6.07e-11 | 2.23e-09 | 200 |
GO:004521622 | Liver | HCC | cell-cell junction organization | 107/7958 | 200/18723 | 1.06e-03 | 6.11e-03 | 107 |
GO:00016553 | Liver | HCC | urogenital system development | 170/7958 | 338/18723 | 2.15e-03 | 1.08e-02 | 170 |
GO:00219154 | Liver | HCC | neural tube development | 82/7958 | 152/18723 | 2.83e-03 | 1.33e-02 | 82 |
GO:00018222 | Liver | HCC | kidney development | 148/7958 | 293/18723 | 3.25e-03 | 1.49e-02 | 148 |
GO:00720012 | Liver | HCC | renal system development | 152/7958 | 302/18723 | 3.45e-03 | 1.56e-02 | 152 |
GO:003433211 | Liver | HCC | adherens junction organization | 30/7958 | 49/18723 | 6.31e-03 | 2.57e-02 | 30 |
GO:000704312 | Liver | HCC | cell-cell junction assembly | 76/7958 | 146/18723 | 1.23e-02 | 4.47e-02 | 76 |
GO:007265928 | Thyroid | ATC | protein localization to plasma membrane | 161/6293 | 284/18723 | 8.45e-16 | 6.52e-14 | 161 |
GO:199077826 | Thyroid | ATC | protein localization to cell periphery | 181/6293 | 333/18723 | 3.72e-15 | 2.56e-13 | 181 |
GO:000150332 | Thyroid | ATC | ossification | 206/6293 | 408/18723 | 9.23e-13 | 3.95e-11 | 206 |
GO:000182222 | Thyroid | ATC | kidney development | 146/6293 | 293/18723 | 5.81e-09 | 1.28e-07 | 146 |
GO:000165522 | Thyroid | ATC | urogenital system development | 164/6293 | 338/18723 | 7.92e-09 | 1.70e-07 | 164 |
GO:007200122 | Thyroid | ATC | renal system development | 149/6293 | 302/18723 | 9.48e-09 | 1.99e-07 | 149 |
GO:006056222 | Thyroid | ATC | epithelial tube morphogenesis | 156/6293 | 325/18723 | 4.48e-08 | 8.14e-07 | 156 |
GO:002191515 | Thyroid | ATC | neural tube development | 80/6293 | 152/18723 | 9.87e-07 | 1.29e-05 | 80 |
GO:006034813 | Thyroid | ATC | bone development | 102/6293 | 205/18723 | 1.18e-06 | 1.52e-05 | 102 |
GO:003432924 | Thyroid | ATC | cell junction assembly | 187/6293 | 420/18723 | 1.71e-06 | 2.08e-05 | 187 |
GO:006048521 | Thyroid | ATC | mesenchyme development | 136/6293 | 291/18723 | 2.04e-06 | 2.43e-05 | 136 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DCHS1 | SNV | Missense_Mutation | c.4C>G | p.Gln2Glu | p.Q2E | Q96JQ0 | protein_coding | deleterious_low_confidence(0) | benign(0.094) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DCHS1 | SNV | Missense_Mutation | rs762213705 | c.2750N>A | p.Arg917Gln | p.R917Q | Q96JQ0 | protein_coding | tolerated(1) | probably_damaging(0.986) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
DCHS1 | SNV | Missense_Mutation | c.2428N>T | p.Gly810Cys | p.G810C | Q96JQ0 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
DCHS1 | SNV | Missense_Mutation | rs200122562 | c.8306N>T | p.Ala2769Val | p.A2769V | Q96JQ0 | protein_coding | tolerated(0.06) | possibly_damaging(0.539) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
DCHS1 | SNV | Missense_Mutation | rs867539218 | c.9043N>T | p.Ala3015Ser | p.A3015S | Q96JQ0 | protein_coding | tolerated(0.32) | benign(0.001) | TCGA-CM-6164-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DCHS1 | SNV | Missense_Mutation | rs147257039 | c.305G>A | p.Arg102His | p.R102H | Q96JQ0 | protein_coding | deleterious(0.03) | benign(0.413) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DCHS1 | SNV | Missense_Mutation | novel | c.1307A>G | p.Asp436Gly | p.D436G | Q96JQ0 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-D5-6929-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatinum+ | SD |
DCHS1 | SNV | Missense_Mutation | c.9187N>G | p.Arg3063Gly | p.R3063G | Q96JQ0 | protein_coding | deleterious(0) | possibly_damaging(0.856) | TCGA-DM-A0XF-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | mayo | CR | |
DCHS1 | SNV | Missense_Mutation | rs755687394 | c.440G>A | p.Arg147Gln | p.R147Q | Q96JQ0 | protein_coding | tolerated(0.23) | benign(0.011) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
DCHS1 | SNV | Missense_Mutation | rs143832439 | c.313C>T | p.Arg105Cys | p.R105C | Q96JQ0 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-DM-A28K-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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