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Gene: CHD9 |
Gene summary for CHD9 |
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Gene information | Species | Human | Gene symbol | CHD9 | Gene ID | 80205 |
Gene name | chromodomain helicase DNA binding protein 9 | |
Gene Alias | AD013 | |
Cytomap | 16q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006325 | UniProtAcc | Q3L8U1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80205 | CHD9 | CA_HPV_1 | Human | Cervix | CC | 1.52e-05 | -2.12e-02 | 0.0264 |
80205 | CHD9 | CA_HPV_3 | Human | Cervix | CC | 5.01e-03 | 1.42e-01 | 0.0414 |
80205 | CHD9 | CCI_1 | Human | Cervix | CC | 3.24e-06 | 9.94e-01 | 0.528 |
80205 | CHD9 | CCI_2 | Human | Cervix | CC | 2.38e-10 | 1.15e+00 | 0.5249 |
80205 | CHD9 | CCI_3 | Human | Cervix | CC | 2.44e-14 | 1.17e+00 | 0.516 |
80205 | CHD9 | L1 | Human | Cervix | CC | 8.80e-03 | -2.50e-01 | 0.0802 |
80205 | CHD9 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.41e-44 | -8.84e-01 | 0.0155 |
80205 | CHD9 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.78e-11 | -5.26e-01 | -0.1808 |
80205 | CHD9 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.36e-02 | -7.31e-01 | 0.0216 |
80205 | CHD9 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.33e-16 | -8.50e-01 | -0.1207 |
80205 | CHD9 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.13e-04 | -6.29e-01 | -0.2061 |
80205 | CHD9 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.76e-08 | -6.54e-01 | -0.0179 |
80205 | CHD9 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.04e-21 | -7.12e-01 | 0.096 |
80205 | CHD9 | HTA11_9408_2000001011 | Human | Colorectum | AD | 4.49e-03 | -7.76e-01 | 0.0451 |
80205 | CHD9 | HTA11_8622_2000001021 | Human | Colorectum | SER | 9.47e-06 | -7.68e-01 | 0.0528 |
80205 | CHD9 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.16e-11 | -5.71e-01 | 0.0338 |
80205 | CHD9 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.34e-02 | -3.63e-01 | 0.0674 |
80205 | CHD9 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.11e-02 | -7.94e-01 | -0.0124 |
80205 | CHD9 | HTA11_11156_2000001011 | Human | Colorectum | AD | 3.54e-04 | -8.97e-01 | 0.0397 |
80205 | CHD9 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.59e-04 | -5.77e-01 | 0.0588 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:00323923 | Cervix | CC | DNA geometric change | 21/2311 | 90/18723 | 2.71e-03 | 1.85e-02 | 21 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0032392 | Colorectum | AD | DNA geometric change | 31/3918 | 90/18723 | 2.02e-03 | 1.63e-02 | 31 |
GO:00063251 | Colorectum | SER | chromatin organization | 89/2897 | 409/18723 | 4.15e-04 | 6.17e-03 | 89 |
GO:00063252 | Colorectum | MSS | chromatin organization | 107/3467 | 409/18723 | 7.22e-05 | 1.21e-03 | 107 |
GO:00323921 | Colorectum | MSS | DNA geometric change | 29/3467 | 90/18723 | 1.26e-03 | 1.20e-02 | 29 |
GO:0032508 | Colorectum | MSS | DNA duplex unwinding | 25/3467 | 84/18723 | 8.27e-03 | 4.99e-02 | 25 |
GO:00063253 | Colorectum | FAP | chromatin organization | 84/2622 | 409/18723 | 1.62e-04 | 2.47e-03 | 84 |
GO:00063254 | Colorectum | CRC | chromatin organization | 74/2078 | 409/18723 | 1.48e-05 | 4.61e-04 | 74 |
GO:000632516 | Esophagus | HGIN | chromatin organization | 92/2587 | 409/18723 | 1.05e-06 | 4.16e-05 | 92 |
GO:00323926 | Esophagus | HGIN | DNA geometric change | 25/2587 | 90/18723 | 3.77e-04 | 5.85e-03 | 25 |
GO:00325084 | Esophagus | HGIN | DNA duplex unwinding | 22/2587 | 84/18723 | 1.91e-03 | 2.03e-02 | 22 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:003239214 | Esophagus | ESCC | DNA geometric change | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:003250813 | Esophagus | ESCC | DNA duplex unwinding | 58/8552 | 84/18723 | 1.23e-05 | 1.14e-04 | 58 |
GO:00063255 | Liver | NAFLD | chromatin organization | 64/1882 | 409/18723 | 2.31e-04 | 3.89e-03 | 64 |
GO:00323922 | Liver | NAFLD | DNA geometric change | 18/1882 | 90/18723 | 3.34e-03 | 2.93e-02 | 18 |
GO:003239211 | Liver | HCC | DNA geometric change | 54/7958 | 90/18723 | 6.04e-04 | 3.79e-03 | 54 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHD9 | SNV | Missense_Mutation | novel | c.6257N>T | p.Pro2086Leu | p.P2086L | Q3L8U1 | protein_coding | tolerated(0.09) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CHD9 | SNV | Missense_Mutation | novel | c.6687N>T | p.Glu2229Asp | p.E2229D | Q3L8U1 | protein_coding | tolerated(0.11) | benign(0.437) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CHD9 | SNV | Missense_Mutation | novel | c.7888N>T | p.Arg2630Trp | p.R2630W | Q3L8U1 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CHD9 | SNV | Missense_Mutation | novel | c.8499N>A | p.Asp2833Glu | p.D2833E | Q3L8U1 | protein_coding | tolerated_low_confidence(0.3) | possibly_damaging(0.753) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHD9 | SNV | Missense_Mutation | rs570326018 | c.6479G>A | p.Arg2160Gln | p.R2160Q | Q3L8U1 | protein_coding | tolerated(0.46) | benign(0.005) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHD9 | SNV | Missense_Mutation | novel | c.157N>G | p.Leu53Val | p.L53V | Q3L8U1 | protein_coding | tolerated_low_confidence(0.12) | benign(0.43) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHD9 | SNV | Missense_Mutation | rs773225940 | c.5683N>T | p.Arg1895Trp | p.R1895W | Q3L8U1 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHD9 | SNV | Missense_Mutation | novel | c.4278N>T | p.Trp1426Cys | p.W1426C | Q3L8U1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AJ-A3BK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHD9 | SNV | Missense_Mutation | novel | c.5350N>T | p.Arg1784Cys | p.R1784C | Q3L8U1 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
CHD9 | SNV | Missense_Mutation | novel | c.1275A>C | p.Gln425His | p.Q425H | Q3L8U1 | protein_coding | deleterious_low_confidence(0.02) | benign(0.001) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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