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Gene: CDH26 |
Gene summary for CDH26 |
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Gene information | Species | Human | Gene symbol | CDH26 | Gene ID | 60437 |
Gene name | cadherin 26 | |
Gene Alias | VR20 | |
Cytomap | 20q13.33 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q8IXH8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
60437 | CDH26 | LZE4T | Human | Esophagus | ESCC | 4.53e-04 | 1.60e-01 | 0.0811 |
60437 | CDH26 | LZE5T | Human | Esophagus | ESCC | 1.00e-09 | 5.59e-01 | 0.0514 |
60437 | CDH26 | P1T-E | Human | Esophagus | ESCC | 7.11e-04 | 3.62e-01 | 0.0875 |
60437 | CDH26 | P5T-E | Human | Esophagus | ESCC | 3.66e-04 | 7.39e-02 | 0.1327 |
60437 | CDH26 | P8T-E | Human | Esophagus | ESCC | 2.20e-17 | 3.04e-01 | 0.0889 |
60437 | CDH26 | P12T-E | Human | Esophagus | ESCC | 3.50e-02 | 8.08e-02 | 0.1122 |
60437 | CDH26 | P23T-E | Human | Esophagus | ESCC | 6.05e-08 | 2.40e-01 | 0.108 |
60437 | CDH26 | P26T-E | Human | Esophagus | ESCC | 3.07e-02 | 1.11e-01 | 0.1276 |
60437 | CDH26 | P39T-E | Human | Esophagus | ESCC | 9.44e-07 | 2.04e-01 | 0.0894 |
60437 | CDH26 | P47T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.31e-01 | 0.1067 |
60437 | CDH26 | P48T-E | Human | Esophagus | ESCC | 3.50e-02 | 9.62e-02 | 0.0959 |
60437 | CDH26 | P54T-E | Human | Esophagus | ESCC | 1.34e-09 | 2.96e-01 | 0.0975 |
60437 | CDH26 | P61T-E | Human | Esophagus | ESCC | 3.11e-12 | 2.83e-01 | 0.099 |
60437 | CDH26 | P74T-E | Human | Esophagus | ESCC | 4.85e-08 | 2.36e-01 | 0.1479 |
60437 | CDH26 | P75T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.86e-01 | 0.1125 |
60437 | CDH26 | P76T-E | Human | Esophagus | ESCC | 2.63e-03 | 7.37e-02 | 0.1207 |
60437 | CDH26 | P83T-E | Human | Esophagus | ESCC | 1.35e-05 | 1.93e-01 | 0.1738 |
60437 | CDH26 | P84T-E | Human | Esophagus | ESCC | 8.33e-03 | 2.42e-01 | 0.0933 |
60437 | CDH26 | P127T-E | Human | Esophagus | ESCC | 1.80e-08 | 1.83e-01 | 0.0826 |
60437 | CDH26 | P128T-E | Human | Esophagus | ESCC | 6.78e-38 | 1.22e+00 | 0.1241 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004211018 | Esophagus | ESCC | T cell activation | 256/8552 | 487/18723 | 1.18e-03 | 5.87e-03 | 256 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDH26 | SNV | Missense_Mutation | rs754090670 | c.807N>A | p.Asn269Lys | p.N269K | Q8IXH8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DD-A1EE-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
CDH26 | SNV | Missense_Mutation | rs547604097 | c.1063N>G | p.Ile355Val | p.I355V | Q8IXH8 | protein_coding | tolerated(0.1) | benign(0.318) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD |
CDH26 | SNV | Missense_Mutation | c.320C>T | p.Ser107Phe | p.S107F | Q8IXH8 | protein_coding | deleterious(0) | benign(0.437) | TCGA-05-4422-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CDH26 | SNV | Missense_Mutation | novel | c.545N>T | p.Gln182Leu | p.Q182L | Q8IXH8 | protein_coding | tolerated(0.11) | benign(0.031) | TCGA-05-4424-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | erlotinib | SD |
CDH26 | SNV | Missense_Mutation | novel | c.1787N>A | p.Pro596His | p.P596H | Q8IXH8 | protein_coding | tolerated(0.54) | benign(0.214) | TCGA-55-6979-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
CDH26 | SNV | Missense_Mutation | novel | c.1472N>T | p.Ser491Phe | p.S491F | Q8IXH8 | protein_coding | deleterious(0.05) | benign(0.052) | TCGA-55-6987-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CDH26 | SNV | Missense_Mutation | novel | c.1574N>T | p.Pro525Leu | p.P525L | Q8IXH8 | protein_coding | tolerated(0.16) | benign(0.065) | TCGA-78-7148-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CDH26 | SNV | Missense_Mutation | rs184110890 | c.902G>A | p.Arg301Gln | p.R301Q | Q8IXH8 | protein_coding | tolerated(0.55) | benign(0) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD |
CDH26 | SNV | Missense_Mutation | novel | c.1264G>T | p.Asp422Tyr | p.D422Y | Q8IXH8 | protein_coding | tolerated(0.3) | probably_damaging(1) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CDH26 | SNV | Missense_Mutation | novel | c.2012N>T | p.Ser671Leu | p.S671L | Q8IXH8 | protein_coding | tolerated(0.75) | benign(0.012) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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