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Gene: CCAR1 |
Gene summary for CCAR1 |
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Gene information | Species | Human | Gene symbol | CCAR1 | Gene ID | 55749 |
Gene name | cell division cycle and apoptosis regulator 1 | |
Gene Alias | CCAR1 | |
Cytomap | 10q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8IX12 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55749 | CCAR1 | LZE2T | Human | Esophagus | ESCC | 2.70e-07 | 9.56e-01 | 0.082 |
55749 | CCAR1 | LZE4T | Human | Esophagus | ESCC | 1.21e-18 | 5.74e-01 | 0.0811 |
55749 | CCAR1 | LZE5T | Human | Esophagus | ESCC | 3.29e-02 | 6.19e-01 | 0.0514 |
55749 | CCAR1 | LZE7T | Human | Esophagus | ESCC | 2.92e-06 | 3.82e-01 | 0.0667 |
55749 | CCAR1 | LZE8T | Human | Esophagus | ESCC | 6.63e-09 | 4.38e-01 | 0.067 |
55749 | CCAR1 | LZE22D1 | Human | Esophagus | HGIN | 5.13e-08 | 1.56e-01 | 0.0595 |
55749 | CCAR1 | LZE22T | Human | Esophagus | ESCC | 1.61e-08 | 4.58e-01 | 0.068 |
55749 | CCAR1 | LZE24T | Human | Esophagus | ESCC | 2.72e-21 | 7.39e-01 | 0.0596 |
55749 | CCAR1 | LZE6T | Human | Esophagus | ESCC | 4.48e-05 | 3.17e-01 | 0.0845 |
55749 | CCAR1 | P1T-E | Human | Esophagus | ESCC | 9.81e-06 | 5.39e-01 | 0.0875 |
55749 | CCAR1 | P2T-E | Human | Esophagus | ESCC | 1.77e-49 | 1.01e+00 | 0.1177 |
55749 | CCAR1 | P4T-E | Human | Esophagus | ESCC | 6.25e-46 | 1.23e+00 | 0.1323 |
55749 | CCAR1 | P5T-E | Human | Esophagus | ESCC | 2.86e-32 | 8.56e-01 | 0.1327 |
55749 | CCAR1 | P8T-E | Human | Esophagus | ESCC | 1.60e-29 | 7.19e-01 | 0.0889 |
55749 | CCAR1 | P9T-E | Human | Esophagus | ESCC | 2.64e-18 | 6.13e-01 | 0.1131 |
55749 | CCAR1 | P10T-E | Human | Esophagus | ESCC | 1.98e-30 | 6.79e-01 | 0.116 |
55749 | CCAR1 | P11T-E | Human | Esophagus | ESCC | 1.10e-20 | 9.25e-01 | 0.1426 |
55749 | CCAR1 | P12T-E | Human | Esophagus | ESCC | 4.59e-38 | 1.04e+00 | 0.1122 |
55749 | CCAR1 | P15T-E | Human | Esophagus | ESCC | 8.13e-24 | 7.34e-01 | 0.1149 |
55749 | CCAR1 | P16T-E | Human | Esophagus | ESCC | 1.79e-41 | 9.25e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCAR1 | deletion | Frame_Shift_Del | c.1295delA | p.Asn432IlefsTer18 | p.N432Ifs*18 | Q8IX12 | protein_coding | TCGA-D1-A0ZO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
CCAR1 | SNV | Missense_Mutation | novel | c.827N>T | p.Ala276Val | p.A276V | Q8IX12 | protein_coding | tolerated(0.27) | benign(0) | TCGA-DD-A3A7-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Chemotherapy | unknown | PD |
CCAR1 | SNV | Missense_Mutation | c.826N>A | p.Ala276Thr | p.A276T | Q8IX12 | protein_coding | tolerated(0.13) | benign(0.011) | TCGA-UB-A7MD-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CCAR1 | insertion | Frame_Shift_Ins | novel | c.57_58insA | p.Ala20SerfsTer74 | p.A20Sfs*74 | Q8IX12 | protein_coding | TCGA-ZP-A9D0-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CCAR1 | SNV | Missense_Mutation | c.1268A>T | p.His423Leu | p.H423L | Q8IX12 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-53-7624-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
CCAR1 | SNV | Missense_Mutation | novel | c.1688N>A | p.Pro563Gln | p.P563Q | Q8IX12 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-53-7626-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unspecific | Cisplatin | PD |
CCAR1 | SNV | Missense_Mutation | novel | c.1389N>T | p.Lys463Asn | p.K463N | Q8IX12 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-69-7974-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
CCAR1 | SNV | Missense_Mutation | c.1201N>A | p.Trp401Arg | p.W401R | Q8IX12 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-86-7955-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | PD | |
CCAR1 | SNV | Missense_Mutation | c.1202N>T | p.Trp401Leu | p.W401L | Q8IX12 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-86-7955-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | PD | |
CCAR1 | SNV | Missense_Mutation | c.2533N>T | p.Arg845Trp | p.R845W | Q8IX12 | protein_coding | deleterious(0.02) | benign(0.237) | TCGA-97-A4M0-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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