![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CASK |
Gene summary for CASK |
![]() |
Gene information | Species | Human | Gene symbol | CASK | Gene ID | 8573 |
Gene name | calcium/calmodulin dependent serine protein kinase | |
Gene Alias | CAGH39 | |
Cytomap | Xp11.4 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | O14936 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8573 | CASK | CCI_1 | Human | Cervix | CC | 3.11e-18 | 1.26e+00 | 0.528 |
8573 | CASK | CCI_2 | Human | Cervix | CC | 4.38e-13 | 1.47e+00 | 0.5249 |
8573 | CASK | CCI_3 | Human | Cervix | CC | 7.57e-17 | 1.17e+00 | 0.516 |
8573 | CASK | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.58e-12 | -3.56e-01 | 0.0155 |
8573 | CASK | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.71e-04 | -3.09e-01 | -0.1808 |
8573 | CASK | HTA11_347_2000001011 | Human | Colorectum | AD | 6.34e-08 | 5.12e-01 | -0.1954 |
8573 | CASK | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.28e-08 | -6.10e-01 | -0.2061 |
8573 | CASK | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.40e-05 | -6.05e-01 | -0.1462 |
8573 | CASK | HTA11_8622_2000001021 | Human | Colorectum | SER | 9.09e-04 | -5.47e-01 | 0.0528 |
8573 | CASK | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.02e-09 | -3.84e-01 | 0.294 |
8573 | CASK | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.41e-20 | 1.25e+00 | 0.281 |
8573 | CASK | A015-C-203 | Human | Colorectum | FAP | 4.08e-39 | -5.54e-01 | -0.1294 |
8573 | CASK | A015-C-204 | Human | Colorectum | FAP | 1.93e-04 | -3.55e-01 | -0.0228 |
8573 | CASK | A014-C-040 | Human | Colorectum | FAP | 4.95e-06 | -5.88e-01 | -0.1184 |
8573 | CASK | A002-C-201 | Human | Colorectum | FAP | 2.55e-11 | -4.03e-01 | 0.0324 |
8573 | CASK | A002-C-203 | Human | Colorectum | FAP | 5.46e-03 | -1.67e-01 | 0.2786 |
8573 | CASK | A001-C-119 | Human | Colorectum | FAP | 3.33e-10 | -5.57e-01 | -0.1557 |
8573 | CASK | A001-C-108 | Human | Colorectum | FAP | 1.60e-16 | -2.73e-01 | -0.0272 |
8573 | CASK | A002-C-205 | Human | Colorectum | FAP | 5.41e-29 | -6.62e-01 | -0.1236 |
8573 | CASK | A015-C-006 | Human | Colorectum | FAP | 6.23e-22 | -7.18e-01 | -0.0994 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206010 | Cervix | CC | wound healing | 109/2311 | 422/18723 | 1.84e-14 | 1.57e-11 | 109 |
GO:001081010 | Cervix | CC | regulation of cell-substrate adhesion | 69/2311 | 221/18723 | 8.57e-14 | 5.69e-11 | 69 |
GO:00315898 | Cervix | CC | cell-substrate adhesion | 96/2311 | 363/18723 | 1.48e-13 | 8.85e-11 | 96 |
GO:00506737 | Cervix | CC | epithelial cell proliferation | 98/2311 | 437/18723 | 2.01e-09 | 2.15e-07 | 98 |
GO:00019528 | Cervix | CC | regulation of cell-matrix adhesion | 40/2311 | 128/18723 | 1.32e-08 | 1.04e-06 | 40 |
GO:00071608 | Cervix | CC | cell-matrix adhesion | 60/2311 | 233/18723 | 1.58e-08 | 1.23e-06 | 60 |
GO:00071626 | Cervix | CC | negative regulation of cell adhesion | 72/2311 | 303/18723 | 2.36e-08 | 1.70e-06 | 72 |
GO:00506787 | Cervix | CC | regulation of epithelial cell proliferation | 83/2311 | 381/18723 | 1.31e-07 | 6.42e-06 | 83 |
GO:19030349 | Cervix | CC | regulation of response to wounding | 44/2311 | 167/18723 | 6.33e-07 | 2.31e-05 | 44 |
GO:00610418 | Cervix | CC | regulation of wound healing | 34/2311 | 134/18723 | 2.70e-05 | 4.52e-04 | 34 |
GO:00108122 | Cervix | CC | negative regulation of cell-substrate adhesion | 21/2311 | 68/18723 | 4.35e-05 | 6.66e-04 | 21 |
GO:00436164 | Cervix | CC | keratinocyte proliferation | 15/2311 | 46/18723 | 2.70e-04 | 2.97e-03 | 15 |
GO:00196939 | Cervix | CC | ribose phosphate metabolic process | 72/2311 | 396/18723 | 4.49e-04 | 4.48e-03 | 72 |
GO:00092599 | Cervix | CC | ribonucleotide metabolic process | 70/2311 | 385/18723 | 5.35e-04 | 5.18e-03 | 70 |
GO:00321022 | Cervix | CC | negative regulation of response to external stimulus | 75/2311 | 420/18723 | 5.96e-04 | 5.61e-03 | 75 |
GO:00108376 | Cervix | CC | regulation of keratinocyte proliferation | 12/2311 | 35/18723 | 6.55e-04 | 6.05e-03 | 12 |
GO:000915010 | Cervix | CC | purine ribonucleotide metabolic process | 66/2311 | 368/18723 | 1.09e-03 | 9.07e-03 | 66 |
GO:00171574 | Cervix | CC | regulation of exocytosis | 39/2311 | 202/18723 | 2.90e-03 | 1.93e-02 | 39 |
GO:000616310 | Cervix | CC | purine nucleotide metabolic process | 67/2311 | 396/18723 | 4.41e-03 | 2.69e-02 | 67 |
GO:007252110 | Cervix | CC | purine-containing compound metabolic process | 69/2311 | 416/18723 | 6.27e-03 | 3.54e-02 | 69 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CASK | SNV | Missense_Mutation | novel | c.2428A>C | p.Met810Leu | p.M810L | O14936 | protein_coding | tolerated(0.13) | benign(0.046) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CASK | SNV | Missense_Mutation | novel | c.1153G>A | p.Asp385Asn | p.D385N | O14936 | protein_coding | tolerated(0.1) | benign(0.001) | TCGA-T2-A6X2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
CASK | SNV | Missense_Mutation | novel | c.2623N>C | p.Asp875His | p.D875H | O14936 | protein_coding | deleterious(0.01) | benign(0.007) | TCGA-TN-A7HL-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
CASK | insertion | In_Frame_Ins | novel | c.357-1_357insTGAAGCTGTAGCCAG | p.Glu115_Ser119dup | p.E115_S119dup | O14936 | protein_coding | TCGA-QK-A8Z7-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR | ||
CASK | SNV | Missense_Mutation | rs777220099 | c.2719C>T | p.Leu907Phe | p.L907F | O14936 | protein_coding | deleterious(0.02) | benign(0.033) | TCGA-BR-6802-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | CR |
CASK | SNV | Missense_Mutation | c.101C>T | p.Thr34Ile | p.T34I | O14936 | protein_coding | deleterious(0) | possibly_damaging(0.895) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
CASK | SNV | Missense_Mutation | novel | c.2504N>G | p.Gln835Arg | p.Q835R | O14936 | protein_coding | deleterious(0) | benign(0.053) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD |
CASK | insertion | Frame_Shift_Ins | novel | c.2255_2256insA | p.Asn752LysfsTer38 | p.N752Kfs*38 | O14936 | protein_coding | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
CASK | insertion | Frame_Shift_Ins | novel | c.2249_2250insCAGA | p.Lys751ArgfsTer40 | p.K751Rfs*40 | O14936 | protein_coding | TCGA-EL-A3ZN-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CASK | insertion | Frame_Shift_Ins | novel | c.2247_2248insCTTATGTA | p.Ile750LeufsTer3 | p.I750Lfs*3 | O14936 | protein_coding | TCGA-EL-A3ZN-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |