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Gene: CAPN3 |
Gene summary for CAPN3 |
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Gene information | Species | Human | Gene symbol | CAPN3 | Gene ID | 825 |
Gene name | calpain 3 | |
Gene Alias | CANP3 | |
Cytomap | 15q15.1 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | P20807 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
825 | CAPN3 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 3.17e-04 | 6.29e-01 | -0.1406 |
825 | CAPN3 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 1.22e-02 | 5.04e-01 | -0.1408 |
825 | CAPN3 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.17e-04 | 3.06e-01 | -0.2116 |
825 | CAPN3 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 2.37e-02 | 4.00e-01 | -0.1941 |
825 | CAPN3 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.81e-06 | 4.37e-01 | -0.2119 |
825 | CAPN3 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 3.36e-06 | 2.96e-01 | -0.0166 |
825 | CAPN3 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.06e-02 | 1.82e-01 | -0.0132 |
825 | CAPN3 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 4.72e-02 | 1.55e-01 | -0.013 |
825 | CAPN3 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.85e-04 | 2.32e-01 | -0.0121 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19033208 | Lung | IAC | regulation of protein modification by small protein conjugation or removal | 64/2061 | 242/18723 | 1.38e-11 | 4.83e-09 | 64 |
GO:00458628 | Lung | IAC | positive regulation of proteolysis | 80/2061 | 372/18723 | 2.62e-09 | 4.21e-07 | 80 |
GO:00310327 | Lung | IAC | actomyosin structure organization | 46/2061 | 196/18723 | 4.70e-07 | 3.10e-05 | 46 |
GO:00316478 | Lung | IAC | regulation of protein stability | 62/2061 | 298/18723 | 5.37e-07 | 3.32e-05 | 62 |
GO:19033218 | Lung | IAC | negative regulation of protein modification by small protein conjugation or removal | 28/2061 | 95/18723 | 7.08e-07 | 4.08e-05 | 28 |
GO:00072495 | Lung | IAC | I-kappaB kinase/NF-kappaB signaling | 56/2061 | 281/18723 | 7.39e-06 | 2.62e-04 | 56 |
GO:00431226 | Lung | IAC | regulation of I-kappaB kinase/NF-kappaB signaling | 51/2061 | 249/18723 | 8.41e-06 | 2.87e-04 | 51 |
GO:00621978 | Lung | IAC | cellular response to chemical stress | 64/2061 | 337/18723 | 8.92e-06 | 3.01e-04 | 64 |
GO:00510903 | Lung | IAC | regulation of DNA-binding transcription factor activity | 76/2061 | 440/18723 | 4.44e-05 | 1.05e-03 | 76 |
GO:00510914 | Lung | IAC | positive regulation of DNA-binding transcription factor activity | 50/2061 | 260/18723 | 5.87e-05 | 1.29e-03 | 50 |
GO:00316483 | Lung | IAC | protein destabilization | 15/2061 | 46/18723 | 7.40e-05 | 1.55e-03 | 15 |
GO:00459276 | Lung | IAC | positive regulation of growth | 49/2061 | 259/18723 | 1.06e-04 | 2.05e-03 | 49 |
GO:00486385 | Lung | IAC | regulation of developmental growth | 59/2061 | 330/18723 | 1.17e-04 | 2.22e-03 | 59 |
GO:00512357 | Lung | IAC | maintenance of location | 58/2061 | 327/18723 | 1.66e-04 | 2.96e-03 | 58 |
GO:0051092 | Lung | IAC | positive regulation of NF-kappaB transcription factor activity | 32/2061 | 152/18723 | 2.25e-04 | 3.90e-03 | 32 |
GO:00712146 | Lung | IAC | cellular response to abiotic stimulus | 58/2061 | 331/18723 | 2.30e-04 | 3.96e-03 | 58 |
GO:01040046 | Lung | IAC | cellular response to environmental stimulus | 58/2061 | 331/18723 | 2.30e-04 | 3.96e-03 | 58 |
GO:0042692 | Lung | IAC | muscle cell differentiation | 65/2061 | 384/18723 | 2.75e-04 | 4.54e-03 | 65 |
GO:00486394 | Lung | IAC | positive regulation of developmental growth | 35/2061 | 174/18723 | 2.96e-04 | 4.79e-03 | 35 |
GO:00515924 | Lung | IAC | response to calcium ion | 31/2061 | 149/18723 | 3.47e-04 | 5.42e-03 | 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAPN3 | SNV | Missense_Mutation | rs863224958 | c.146N>A | p.Arg49His | p.R49H | P20807 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAPN3 | SNV | Missense_Mutation | c.2370N>T | p.Glu790Asp | p.E790D | P20807 | protein_coding | deleterious(0.03) | benign(0.101) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CAPN3 | SNV | Missense_Mutation | c.1310N>A | p.Arg437His | p.R437H | P20807 | protein_coding | tolerated(0.05) | probably_damaging(0.994) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
CAPN3 | SNV | Missense_Mutation | rs373919252 | c.5C>T | p.Pro2Leu | p.P2L | P20807 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
CAPN3 | SNV | Missense_Mutation | rs767398783 | c.1382G>A | p.Arg461His | p.R461H | P20807 | protein_coding | tolerated(0.06) | probably_damaging(1) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
CAPN3 | SNV | Missense_Mutation | c.598N>A | p.Phe200Ile | p.F200I | P20807 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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