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Gene: ATAD2B |
Gene summary for ATAD2B |
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Gene information | Species | Human | Gene symbol | ATAD2B | Gene ID | 54454 |
Gene name | ATPase family AAA domain containing 2B | |
Gene Alias | ATAD2B | |
Cytomap | 2p24.1-p23.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9ULI0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54454 | ATAD2B | CCI_1 | Human | Cervix | CC | 1.02e-02 | 8.10e-01 | 0.528 |
54454 | ATAD2B | CCI_2 | Human | Cervix | CC | 2.62e-10 | 1.08e+00 | 0.5249 |
54454 | ATAD2B | CCI_3 | Human | Cervix | CC | 4.99e-06 | 7.66e-01 | 0.516 |
54454 | ATAD2B | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.71e-13 | -5.98e-01 | 0.0155 |
54454 | ATAD2B | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.09e-02 | -7.45e-01 | 0.0216 |
54454 | ATAD2B | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.97e-05 | -4.11e-01 | -0.1207 |
54454 | ATAD2B | HTA11_696_2000001011 | Human | Colorectum | AD | 1.38e-04 | -3.20e-01 | -0.1464 |
54454 | ATAD2B | HTA11_866_3004761011 | Human | Colorectum | AD | 1.71e-06 | -5.21e-01 | 0.096 |
54454 | ATAD2B | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.92e-02 | -6.10e-01 | 0.0528 |
54454 | ATAD2B | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.70e-03 | -5.06e-01 | 0.0338 |
54454 | ATAD2B | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.50e-10 | -4.75e-01 | 0.0674 |
54454 | ATAD2B | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.82e-02 | -5.16e-01 | 0.0112 |
54454 | ATAD2B | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.08e-05 | -6.23e-01 | 0.0588 |
54454 | ATAD2B | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.31e-18 | -5.47e-01 | 0.294 |
54454 | ATAD2B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.41e-22 | -5.56e-01 | 0.3859 |
54454 | ATAD2B | HTA11_99999973899_84307 | Human | Colorectum | MSS | 8.33e-03 | -6.08e-01 | 0.2585 |
54454 | ATAD2B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.65e-08 | -4.47e-01 | 0.3005 |
54454 | ATAD2B | F007 | Human | Colorectum | FAP | 2.68e-03 | -3.68e-01 | 0.1176 |
54454 | ATAD2B | A015-C-203 | Human | Colorectum | FAP | 6.05e-30 | -4.03e-01 | -0.1294 |
54454 | ATAD2B | A015-C-204 | Human | Colorectum | FAP | 2.66e-05 | -2.61e-01 | -0.0228 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:00063381 | Cervix | CC | chromatin remodeling | 45/2311 | 255/18723 | 8.33e-03 | 4.30e-02 | 45 |
GO:00063258 | Endometrium | AEH | chromatin organization | 64/2100 | 409/18723 | 3.69e-03 | 2.52e-02 | 64 |
GO:000632513 | Endometrium | EEC | chromatin organization | 65/2168 | 409/18723 | 4.98e-03 | 3.14e-02 | 65 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00063255 | Liver | NAFLD | chromatin organization | 64/1882 | 409/18723 | 2.31e-04 | 3.89e-03 | 64 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:00063256 | Lung | IAC | chromatin organization | 69/2061 | 409/18723 | 2.01e-04 | 3.53e-03 | 69 |
GO:000632512 | Lung | AIS | chromatin organization | 62/1849 | 409/18723 | 4.24e-04 | 7.29e-03 | 62 |
GO:000632510 | Oral cavity | OSCC | chromatin organization | 190/7305 | 409/18723 | 1.17e-03 | 5.97e-03 | 190 |
GO:000632515 | Oral cavity | EOLP | chromatin organization | 84/2218 | 409/18723 | 2.68e-07 | 8.16e-06 | 84 |
GO:00063383 | Oral cavity | EOLP | chromatin remodeling | 46/2218 | 255/18723 | 2.34e-03 | 1.44e-02 | 46 |
GO:000632521 | Oral cavity | NEOLP | chromatin organization | 70/2005 | 409/18723 | 4.97e-05 | 6.83e-04 | 70 |
GO:00063259 | Prostate | BPH | chromatin organization | 101/3107 | 409/18723 | 1.52e-05 | 1.94e-04 | 101 |
GO:00063382 | Prostate | BPH | chromatin remodeling | 62/3107 | 255/18723 | 9.47e-04 | 5.97e-03 | 62 |
GO:000632514 | Prostate | Tumor | chromatin organization | 104/3246 | 409/18723 | 2.02e-05 | 2.62e-04 | 104 |
GO:000633811 | Prostate | Tumor | chromatin remodeling | 63/3246 | 255/18723 | 1.73e-03 | 1.02e-02 | 63 |
GO:000632520 | Thyroid | PTC | chromatin organization | 183/5968 | 409/18723 | 2.55e-08 | 5.70e-07 | 183 |
GO:00063385 | Thyroid | PTC | chromatin remodeling | 106/5968 | 255/18723 | 6.56e-04 | 4.13e-03 | 106 |
GO:0006325110 | Thyroid | ATC | chromatin organization | 189/6293 | 409/18723 | 6.40e-08 | 1.13e-06 | 189 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATAD2B | SNV | Missense_Mutation | c.3652G>A | p.Gly1218Arg | p.G1218R | Q9ULI0 | protein_coding | tolerated(0.12) | benign(0.255) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ATAD2B | SNV | Missense_Mutation | c.2381N>G | p.Phe794Cys | p.F794C | Q9ULI0 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-D1-A17R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ATAD2B | SNV | Missense_Mutation | novel | c.2773N>A | p.Ala925Thr | p.A925T | Q9ULI0 | protein_coding | tolerated(0.35) | benign(0.003) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ATAD2B | SNV | Missense_Mutation | novel | c.2182N>T | p.Ile728Phe | p.I728F | Q9ULI0 | protein_coding | deleterious(0) | possibly_damaging(0.662) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ATAD2B | SNV | Missense_Mutation | novel | c.3418C>T | p.Arg1140Trp | p.R1140W | Q9ULI0 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATAD2B | SNV | Missense_Mutation | novel | c.2708G>A | p.Arg903Lys | p.R903K | Q9ULI0 | protein_coding | deleterious(0) | benign(0.024) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATAD2B | SNV | Missense_Mutation | novel | c.3259N>G | p.Leu1087Val | p.L1087V | Q9ULI0 | protein_coding | tolerated(0.32) | benign(0.031) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ATAD2B | SNV | Missense_Mutation | novel | c.4265G>T | p.Arg1422Ile | p.R1422I | Q9ULI0 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATAD2B | SNV | Missense_Mutation | novel | c.2216A>C | p.Lys739Thr | p.K739T | Q9ULI0 | protein_coding | tolerated(0.06) | probably_damaging(0.967) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATAD2B | SNV | Missense_Mutation | novel | c.1953A>C | p.Gln651His | p.Q651H | Q9ULI0 | protein_coding | tolerated(0.07) | benign(0.018) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
54454 | ATAD2B | ENZYME | inhibitor | 336446907 | ||
54454 | ATAD2B | ENZYME | inhibitor | 385612205 |
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