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Gene: ARSJ |
Gene summary for ARSJ |
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Gene information | Species | Human | Gene symbol | ARSJ | Gene ID | 79642 |
Gene name | arylsulfatase family member J | |
Gene Alias | ASJ | |
Cytomap | 4q26 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q5FYB0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79642 | ARSJ | LZE7T | Human | Esophagus | ESCC | 1.41e-06 | 1.63e-01 | 0.0667 |
79642 | ARSJ | LZE8T | Human | Esophagus | ESCC | 2.36e-05 | 1.40e-01 | 0.067 |
79642 | ARSJ | LZE24T | Human | Esophagus | ESCC | 3.23e-03 | 6.71e-02 | 0.0596 |
79642 | ARSJ | P2T-E | Human | Esophagus | ESCC | 1.37e-30 | 5.84e-01 | 0.1177 |
79642 | ARSJ | P4T-E | Human | Esophagus | ESCC | 8.06e-10 | 4.71e-01 | 0.1323 |
79642 | ARSJ | P5T-E | Human | Esophagus | ESCC | 2.31e-10 | 2.39e-01 | 0.1327 |
79642 | ARSJ | P8T-E | Human | Esophagus | ESCC | 1.22e-16 | 4.11e-01 | 0.0889 |
79642 | ARSJ | P9T-E | Human | Esophagus | ESCC | 6.90e-07 | 1.18e-01 | 0.1131 |
79642 | ARSJ | P10T-E | Human | Esophagus | ESCC | 1.42e-05 | 1.34e-01 | 0.116 |
79642 | ARSJ | P12T-E | Human | Esophagus | ESCC | 2.28e-49 | 1.15e+00 | 0.1122 |
79642 | ARSJ | P15T-E | Human | Esophagus | ESCC | 1.89e-15 | 5.30e-01 | 0.1149 |
79642 | ARSJ | P16T-E | Human | Esophagus | ESCC | 3.52e-28 | 6.36e-01 | 0.1153 |
79642 | ARSJ | P21T-E | Human | Esophagus | ESCC | 2.18e-12 | 3.32e-01 | 0.1617 |
79642 | ARSJ | P23T-E | Human | Esophagus | ESCC | 6.71e-04 | 2.65e-01 | 0.108 |
79642 | ARSJ | P24T-E | Human | Esophagus | ESCC | 5.79e-12 | 1.45e-01 | 0.1287 |
79642 | ARSJ | P26T-E | Human | Esophagus | ESCC | 2.82e-52 | 1.13e+00 | 0.1276 |
79642 | ARSJ | P27T-E | Human | Esophagus | ESCC | 1.05e-14 | 4.32e-01 | 0.1055 |
79642 | ARSJ | P28T-E | Human | Esophagus | ESCC | 4.27e-03 | -7.65e-03 | 0.1149 |
79642 | ARSJ | P31T-E | Human | Esophagus | ESCC | 7.20e-26 | 7.16e-01 | 0.1251 |
79642 | ARSJ | P32T-E | Human | Esophagus | ESCC | 5.07e-36 | 7.24e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARSJ | SNV | Missense_Mutation | c.830G>T | p.Arg277Met | p.R277M | Q5FYB0 | protein_coding | deleterious(0.02) | benign(0.043) | TCGA-49-6742-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | alimta | PD | |
ARSJ | SNV | Missense_Mutation | c.830G>A | p.Arg277Lys | p.R277K | Q5FYB0 | protein_coding | tolerated(0.67) | benign(0.003) | TCGA-50-6592-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ARSJ | SNV | Missense_Mutation | novel | c.215C>T | p.Ser72Phe | p.S72F | Q5FYB0 | protein_coding | tolerated(0.07) | benign(0.001) | TCGA-55-6982-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | gemzar | PD |
ARSJ | SNV | Missense_Mutation | novel | c.298N>G | p.Thr100Ala | p.T100A | Q5FYB0 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-62-8395-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ARSJ | SNV | Missense_Mutation | c.19G>A | p.Ala7Thr | p.A7T | Q5FYB0 | protein_coding | deleterious_low_confidence(0.02) | benign(0.023) | TCGA-75-6214-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | PD | |
ARSJ | SNV | Missense_Mutation | novel | c.971N>T | p.Tyr324Phe | p.Y324F | Q5FYB0 | protein_coding | tolerated(1) | benign(0.035) | TCGA-22-1016-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ARSJ | SNV | Missense_Mutation | novel | c.651N>C | p.Met217Ile | p.M217I | Q5FYB0 | protein_coding | tolerated(0.42) | benign(0.006) | TCGA-43-7656-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ARSJ | SNV | Missense_Mutation | novel | c.150N>T | p.Leu50Phe | p.L50F | Q5FYB0 | protein_coding | tolerated_low_confidence(0.21) | benign(0.091) | TCGA-85-8481-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ARSJ | SNV | Missense_Mutation | novel | c.982N>C | p.Asn328His | p.N328H | Q5FYB0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-85-A53L-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARSJ | SNV | Missense_Mutation | rs746575851 | c.512N>T | p.Thr171Met | p.T171M | Q5FYB0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-4P-AA8J-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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