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Gene: ARHGEF2 |
Gene summary for ARHGEF2 |
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Gene information | Species | Human | Gene symbol | ARHGEF2 | Gene ID | 9181 |
Gene name | Rho/Rac guanine nucleotide exchange factor 2 | |
Gene Alias | GEF | |
Cytomap | 1q22 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q92974 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9181 | ARHGEF2 | LZE7T | Human | Esophagus | ESCC | 5.06e-09 | 4.46e-01 | 0.0667 |
9181 | ARHGEF2 | LZE24T | Human | Esophagus | ESCC | 1.89e-03 | 5.31e-02 | 0.0596 |
9181 | ARHGEF2 | P2T-E | Human | Esophagus | ESCC | 1.35e-27 | 6.32e-01 | 0.1177 |
9181 | ARHGEF2 | P4T-E | Human | Esophagus | ESCC | 1.54e-07 | 2.35e-01 | 0.1323 |
9181 | ARHGEF2 | P5T-E | Human | Esophagus | ESCC | 2.90e-07 | 1.38e-01 | 0.1327 |
9181 | ARHGEF2 | P8T-E | Human | Esophagus | ESCC | 6.50e-09 | 1.25e-01 | 0.0889 |
9181 | ARHGEF2 | P9T-E | Human | Esophagus | ESCC | 1.86e-08 | 1.84e-01 | 0.1131 |
9181 | ARHGEF2 | P10T-E | Human | Esophagus | ESCC | 9.96e-19 | 3.10e-01 | 0.116 |
9181 | ARHGEF2 | P11T-E | Human | Esophagus | ESCC | 8.03e-08 | 5.21e-01 | 0.1426 |
9181 | ARHGEF2 | P12T-E | Human | Esophagus | ESCC | 6.61e-17 | 1.66e-01 | 0.1122 |
9181 | ARHGEF2 | P15T-E | Human | Esophagus | ESCC | 1.69e-09 | 1.88e-01 | 0.1149 |
9181 | ARHGEF2 | P16T-E | Human | Esophagus | ESCC | 2.91e-12 | 2.88e-01 | 0.1153 |
9181 | ARHGEF2 | P19T-E | Human | Esophagus | ESCC | 7.98e-03 | 4.43e-01 | 0.1662 |
9181 | ARHGEF2 | P20T-E | Human | Esophagus | ESCC | 5.10e-09 | 1.03e-01 | 0.1124 |
9181 | ARHGEF2 | P21T-E | Human | Esophagus | ESCC | 4.04e-15 | 1.53e-01 | 0.1617 |
9181 | ARHGEF2 | P22T-E | Human | Esophagus | ESCC | 4.45e-07 | 9.84e-02 | 0.1236 |
9181 | ARHGEF2 | P23T-E | Human | Esophagus | ESCC | 1.25e-07 | 2.08e-01 | 0.108 |
9181 | ARHGEF2 | P24T-E | Human | Esophagus | ESCC | 1.18e-11 | 3.11e-01 | 0.1287 |
9181 | ARHGEF2 | P26T-E | Human | Esophagus | ESCC | 4.21e-04 | 1.04e-01 | 0.1276 |
9181 | ARHGEF2 | P27T-E | Human | Esophagus | ESCC | 3.21e-06 | 2.12e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:00072656 | Cervix | CC | Ras protein signal transduction | 79/2311 | 337/18723 | 9.49e-09 | 7.77e-07 | 79 |
GO:00072666 | Cervix | CC | Rho protein signal transduction | 35/2311 | 137/18723 | 1.77e-05 | 3.33e-04 | 35 |
GO:00465785 | Cervix | CC | regulation of Ras protein signal transduction | 44/2311 | 189/18723 | 2.05e-05 | 3.73e-04 | 44 |
GO:00350235 | Cervix | CC | regulation of Rho protein signal transduction | 22/2311 | 86/18723 | 5.93e-04 | 5.60e-03 | 22 |
GO:00480131 | Cervix | CC | ephrin receptor signaling pathway | 14/2311 | 51/18723 | 2.78e-03 | 1.87e-02 | 14 |
GO:0097193111 | Esophagus | ESCC | intrinsic apoptotic signaling pathway | 222/8552 | 288/18723 | 5.87e-28 | 2.02e-25 | 222 |
GO:2001233111 | Esophagus | ESCC | regulation of apoptotic signaling pathway | 256/8552 | 356/18723 | 4.11e-24 | 1.04e-21 | 256 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:2001242111 | Esophagus | ESCC | regulation of intrinsic apoptotic signaling pathway | 128/8552 | 164/18723 | 1.75e-17 | 1.50e-15 | 128 |
GO:0097191111 | Esophagus | ESCC | extrinsic apoptotic signaling pathway | 159/8552 | 219/18723 | 4.12e-16 | 2.94e-14 | 159 |
GO:2001234111 | Esophagus | ESCC | negative regulation of apoptotic signaling pathway | 161/8552 | 224/18723 | 1.24e-15 | 8.09e-14 | 161 |
GO:2001236111 | Esophagus | ESCC | regulation of extrinsic apoptotic signaling pathway | 111/8552 | 151/18723 | 2.97e-12 | 1.18e-10 | 111 |
GO:2001243111 | Esophagus | ESCC | negative regulation of intrinsic apoptotic signaling pathway | 78/8552 | 98/18723 | 5.50e-12 | 2.10e-10 | 78 |
GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
GO:1902903111 | Esophagus | ESCC | regulation of supramolecular fiber organization | 237/8552 | 383/18723 | 9.06e-11 | 2.75e-09 | 237 |
GO:007121419 | Esophagus | ESCC | cellular response to abiotic stimulus | 206/8552 | 331/18723 | 7.52e-10 | 1.88e-08 | 206 |
GO:010400419 | Esophagus | ESCC | cellular response to environmental stimulus | 206/8552 | 331/18723 | 7.52e-10 | 1.88e-08 | 206 |
GO:0010639110 | Esophagus | ESCC | negative regulation of organelle organization | 215/8552 | 348/18723 | 8.20e-10 | 2.01e-08 | 215 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05418211 | Esophagus | ESCC | Fluid shear stress and atherosclerosis | 109/4205 | 139/8465 | 2.00e-12 | 3.72e-11 | 1.90e-11 | 109 |
hsa05131211 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa05130211 | Esophagus | ESCC | Pathogenic Escherichia coli infection | 142/4205 | 197/8465 | 8.21e-11 | 1.06e-09 | 5.42e-10 | 142 |
hsa04530211 | Esophagus | ESCC | Tight junction | 105/4205 | 169/8465 | 6.73e-04 | 2.23e-03 | 1.14e-03 | 105 |
hsa05418310 | Esophagus | ESCC | Fluid shear stress and atherosclerosis | 109/4205 | 139/8465 | 2.00e-12 | 3.72e-11 | 1.90e-11 | 109 |
hsa05131310 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa05130310 | Esophagus | ESCC | Pathogenic Escherichia coli infection | 142/4205 | 197/8465 | 8.21e-11 | 1.06e-09 | 5.42e-10 | 142 |
hsa04530310 | Esophagus | ESCC | Tight junction | 105/4205 | 169/8465 | 6.73e-04 | 2.23e-03 | 1.14e-03 | 105 |
hsa0513042 | Liver | HCC | Pathogenic Escherichia coli infection | 129/4020 | 197/8465 | 2.02e-07 | 2.50e-06 | 1.39e-06 | 129 |
hsa0453042 | Liver | HCC | Tight junction | 110/4020 | 169/8465 | 2.45e-06 | 2.28e-05 | 1.27e-05 | 110 |
hsa0513142 | Liver | HCC | Shigellosis | 150/4020 | 247/8465 | 1.53e-05 | 1.04e-04 | 5.81e-05 | 150 |
hsa0541842 | Liver | HCC | Fluid shear stress and atherosclerosis | 89/4020 | 139/8465 | 5.58e-05 | 2.88e-04 | 1.60e-04 | 89 |
hsa0513052 | Liver | HCC | Pathogenic Escherichia coli infection | 129/4020 | 197/8465 | 2.02e-07 | 2.50e-06 | 1.39e-06 | 129 |
hsa0453052 | Liver | HCC | Tight junction | 110/4020 | 169/8465 | 2.45e-06 | 2.28e-05 | 1.27e-05 | 110 |
hsa0513152 | Liver | HCC | Shigellosis | 150/4020 | 247/8465 | 1.53e-05 | 1.04e-04 | 5.81e-05 | 150 |
hsa0541852 | Liver | HCC | Fluid shear stress and atherosclerosis | 89/4020 | 139/8465 | 5.58e-05 | 2.88e-04 | 1.60e-04 | 89 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGEF2 | SNV | Missense_Mutation | c.2859N>A | p.Ser953Arg | p.S953R | Q92974 | protein_coding | tolerated_low_confidence(0.06) | benign(0) | TCGA-21-5787-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
ARHGEF2 | SNV | Missense_Mutation | c.1606N>G | p.Lys536Glu | p.K536E | Q92974 | protein_coding | deleterious(0) | possibly_damaging(0.76) | TCGA-22-4604-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Targeted Molecular therapy | iressa | PD | |
ARHGEF2 | SNV | Missense_Mutation | c.1233N>T | p.Glu411Asp | p.E411D | Q92974 | protein_coding | tolerated(0.45) | probably_damaging(0.99) | TCGA-22-5472-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
ARHGEF2 | SNV | Missense_Mutation | novel | c.1914G>T | p.Arg638Ser | p.R638S | Q92974 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-33-AASL-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ARHGEF2 | SNV | Missense_Mutation | novel | c.290N>T | p.Ala97Val | p.A97V | Q92974 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-56-8308-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | paclitaxel | SD |
ARHGEF2 | SNV | Missense_Mutation | novel | c.991G>T | p.Ala331Ser | p.A331S | Q92974 | protein_coding | deleterious(0.02) | benign(0.243) | TCGA-94-7943-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ARHGEF2 | SNV | Missense_Mutation | novel | c.797N>G | p.Leu266Arg | p.L266R | Q92974 | protein_coding | deleterious(0.01) | possibly_damaging(0.895) | TCGA-94-8035-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unspecific | Complete Response | |
ARHGEF2 | deletion | Frame_Shift_Del | novel | c.2013delN | p.Pro672GlnfsTer7 | p.P672Qfs*7 | Q92974 | protein_coding | TCGA-66-2758-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | ||
ARHGEF2 | SNV | Missense_Mutation | novel | c.1354N>T | p.Arg452Trp | p.R452W | Q92974 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-CQ-A4C6-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARHGEF2 | SNV | Missense_Mutation | novel | c.2537G>T | p.Arg846Leu | p.R846L | Q92974 | protein_coding | deleterious(0.01) | possibly_damaging(0.76) | TCGA-CR-7398-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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