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Gene: ARHGEF1 |
Gene summary for ARHGEF1 |
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Gene information | Species | Human | Gene symbol | ARHGEF1 | Gene ID | 9138 |
Gene name | Rho guanine nucleotide exchange factor 1 | |
Gene Alias | GEF1 | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A0A024R0R1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9138 | ARHGEF1 | LZE2T | Human | Esophagus | ESCC | 2.88e-04 | 5.07e-01 | 0.082 |
9138 | ARHGEF1 | LZE4T | Human | Esophagus | ESCC | 5.87e-07 | 2.35e-01 | 0.0811 |
9138 | ARHGEF1 | LZE7T | Human | Esophagus | ESCC | 1.58e-17 | 6.18e-01 | 0.0667 |
9138 | ARHGEF1 | LZE22T | Human | Esophagus | ESCC | 8.54e-07 | 4.11e-01 | 0.068 |
9138 | ARHGEF1 | LZE24T | Human | Esophagus | ESCC | 1.17e-14 | 4.52e-01 | 0.0596 |
9138 | ARHGEF1 | LZE21T | Human | Esophagus | ESCC | 2.11e-02 | 2.67e-01 | 0.0655 |
9138 | ARHGEF1 | LZE6T | Human | Esophagus | ESCC | 3.72e-15 | 5.36e-01 | 0.0845 |
9138 | ARHGEF1 | P1T-E | Human | Esophagus | ESCC | 5.82e-08 | 3.10e-01 | 0.0875 |
9138 | ARHGEF1 | P2T-E | Human | Esophagus | ESCC | 1.80e-19 | 2.94e-01 | 0.1177 |
9138 | ARHGEF1 | P4T-E | Human | Esophagus | ESCC | 1.02e-10 | 1.61e-01 | 0.1323 |
9138 | ARHGEF1 | P5T-E | Human | Esophagus | ESCC | 1.42e-11 | 1.73e-01 | 0.1327 |
9138 | ARHGEF1 | P8T-E | Human | Esophagus | ESCC | 8.74e-50 | 8.33e-01 | 0.0889 |
9138 | ARHGEF1 | P9T-E | Human | Esophagus | ESCC | 9.37e-07 | 1.34e-01 | 0.1131 |
9138 | ARHGEF1 | P10T-E | Human | Esophagus | ESCC | 3.42e-23 | 4.25e-01 | 0.116 |
9138 | ARHGEF1 | P11T-E | Human | Esophagus | ESCC | 4.07e-22 | 8.20e-01 | 0.1426 |
9138 | ARHGEF1 | P12T-E | Human | Esophagus | ESCC | 6.03e-25 | 2.95e-01 | 0.1122 |
9138 | ARHGEF1 | P15T-E | Human | Esophagus | ESCC | 7.47e-19 | 4.98e-01 | 0.1149 |
9138 | ARHGEF1 | P16T-E | Human | Esophagus | ESCC | 2.10e-21 | 2.67e-01 | 0.1153 |
9138 | ARHGEF1 | P17T-E | Human | Esophagus | ESCC | 2.44e-09 | 4.41e-01 | 0.1278 |
9138 | ARHGEF1 | P19T-E | Human | Esophagus | ESCC | 4.01e-10 | 6.90e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000701510 | Cervix | CC | actin filament organization | 109/2311 | 442/18723 | 4.92e-13 | 2.45e-10 | 109 |
GO:003297010 | Cervix | CC | regulation of actin filament-based process | 96/2311 | 397/18723 | 4.00e-11 | 8.54e-09 | 96 |
GO:00071639 | Cervix | CC | establishment or maintenance of cell polarity | 63/2311 | 218/18723 | 4.25e-11 | 8.76e-09 | 63 |
GO:190290310 | Cervix | CC | regulation of supramolecular fiber organization | 92/2311 | 383/18723 | 1.49e-10 | 2.48e-08 | 92 |
GO:003295610 | Cervix | CC | regulation of actin cytoskeleton organization | 86/2311 | 358/18723 | 5.90e-10 | 7.51e-08 | 86 |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:00072656 | Cervix | CC | Ras protein signal transduction | 79/2311 | 337/18723 | 9.49e-09 | 7.77e-07 | 79 |
GO:011005310 | Cervix | CC | regulation of actin filament organization | 67/2311 | 278/18723 | 4.01e-08 | 2.54e-06 | 67 |
GO:00300108 | Cervix | CC | establishment of cell polarity | 42/2311 | 143/18723 | 4.30e-08 | 2.62e-06 | 42 |
GO:006157210 | Cervix | CC | actin filament bundle organization | 44/2311 | 161/18723 | 2.08e-07 | 9.34e-06 | 44 |
GO:005101710 | Cervix | CC | actin filament bundle assembly | 43/2311 | 157/18723 | 2.66e-07 | 1.12e-05 | 43 |
GO:190290510 | Cervix | CC | positive regulation of supramolecular fiber organization | 50/2311 | 209/18723 | 2.55e-06 | 7.54e-05 | 50 |
GO:00160498 | Cervix | CC | cell growth | 92/2311 | 482/18723 | 1.16e-05 | 2.49e-04 | 92 |
GO:00072666 | Cervix | CC | Rho protein signal transduction | 35/2311 | 137/18723 | 1.77e-05 | 3.33e-04 | 35 |
GO:005149510 | Cervix | CC | positive regulation of cytoskeleton organization | 50/2311 | 226/18723 | 2.53e-05 | 4.29e-04 | 50 |
GO:003223110 | Cervix | CC | regulation of actin filament bundle assembly | 28/2311 | 105/18723 | 5.19e-05 | 7.79e-04 | 28 |
GO:011002010 | Cervix | CC | regulation of actomyosin structure organization | 27/2311 | 100/18723 | 5.55e-05 | 8.10e-04 | 27 |
GO:00069846 | Cervix | CC | ER-nucleus signaling pathway | 16/2311 | 46/18723 | 7.12e-05 | 9.90e-04 | 16 |
GO:005149210 | Cervix | CC | regulation of stress fiber assembly | 25/2311 | 91/18723 | 7.59e-05 | 1.04e-03 | 25 |
GO:00310329 | Cervix | CC | actomyosin structure organization | 43/2311 | 196/18723 | 1.11e-04 | 1.40e-03 | 43 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05130211 | Esophagus | ESCC | Pathogenic Escherichia coli infection | 142/4205 | 197/8465 | 8.21e-11 | 1.06e-09 | 5.42e-10 | 142 |
hsa0513526 | Esophagus | ESCC | Yersinia infection | 100/4205 | 137/8465 | 1.80e-08 | 1.59e-07 | 8.12e-08 | 100 |
hsa0520529 | Esophagus | ESCC | Proteoglycans in cancer | 138/4205 | 205/8465 | 1.79e-07 | 1.40e-06 | 7.15e-07 | 138 |
hsa05417211 | Esophagus | ESCC | Lipid and atherosclerosis | 143/4205 | 215/8465 | 3.30e-07 | 2.45e-06 | 1.26e-06 | 143 |
hsa05163210 | Esophagus | ESCC | Human cytomegalovirus infection | 148/4205 | 225/8465 | 5.73e-07 | 4.00e-06 | 2.05e-06 | 148 |
hsa0481028 | Esophagus | ESCC | Regulation of actin cytoskeleton | 133/4205 | 229/8465 | 5.94e-03 | 1.48e-02 | 7.56e-03 | 133 |
hsa05130310 | Esophagus | ESCC | Pathogenic Escherichia coli infection | 142/4205 | 197/8465 | 8.21e-11 | 1.06e-09 | 5.42e-10 | 142 |
hsa05135111 | Esophagus | ESCC | Yersinia infection | 100/4205 | 137/8465 | 1.80e-08 | 1.59e-07 | 8.12e-08 | 100 |
hsa0520537 | Esophagus | ESCC | Proteoglycans in cancer | 138/4205 | 205/8465 | 1.79e-07 | 1.40e-06 | 7.15e-07 | 138 |
hsa05417310 | Esophagus | ESCC | Lipid and atherosclerosis | 143/4205 | 215/8465 | 3.30e-07 | 2.45e-06 | 1.26e-06 | 143 |
hsa0516338 | Esophagus | ESCC | Human cytomegalovirus infection | 148/4205 | 225/8465 | 5.73e-07 | 4.00e-06 | 2.05e-06 | 148 |
hsa04810112 | Esophagus | ESCC | Regulation of actin cytoskeleton | 133/4205 | 229/8465 | 5.94e-03 | 1.48e-02 | 7.56e-03 | 133 |
hsa0481021 | Liver | Cirrhotic | Regulation of actin cytoskeleton | 100/2530 | 229/8465 | 5.28e-06 | 5.50e-05 | 3.39e-05 | 100 |
hsa0513022 | Liver | Cirrhotic | Pathogenic Escherichia coli infection | 88/2530 | 197/8465 | 6.48e-06 | 6.24e-05 | 3.84e-05 | 88 |
hsa0520510 | Liver | Cirrhotic | Proteoglycans in cancer | 85/2530 | 205/8465 | 2.37e-04 | 1.58e-03 | 9.75e-04 | 85 |
hsa0513522 | Liver | Cirrhotic | Yersinia infection | 57/2530 | 137/8465 | 2.16e-03 | 9.41e-03 | 5.80e-03 | 57 |
hsa0516312 | Liver | Cirrhotic | Human cytomegalovirus infection | 87/2530 | 225/8465 | 2.67e-03 | 1.10e-02 | 6.76e-03 | 87 |
hsa0541722 | Liver | Cirrhotic | Lipid and atherosclerosis | 80/2530 | 215/8465 | 1.18e-02 | 3.81e-02 | 2.35e-02 | 80 |
hsa0481031 | Liver | Cirrhotic | Regulation of actin cytoskeleton | 100/2530 | 229/8465 | 5.28e-06 | 5.50e-05 | 3.39e-05 | 100 |
hsa0513032 | Liver | Cirrhotic | Pathogenic Escherichia coli infection | 88/2530 | 197/8465 | 6.48e-06 | 6.24e-05 | 3.84e-05 | 88 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGEF1 | SNV | Missense_Mutation | novel | c.687N>C | p.Lys229Asn | p.K229N | Q92888 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-T2-A6X2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ARHGEF1 | deletion | Frame_Shift_Del | novel | c.1654_1663delNNNNNNNNNN | p.Ala553ArgfsTer14 | p.A553Rfs*14 | Q92888 | protein_coding | TCGA-CR-6472-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD | ||
ARHGEF1 | deletion | In_Frame_Del | novel | c.792_815delNNNNNNNNNNNNNNNNNNNNNNNN | p.Met265_Glu272del | p.M265_E272del | Q92888 | protein_coding | TCGA-CV-5977-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
ARHGEF1 | SNV | Missense_Mutation | rs782110668 | c.205N>T | p.Arg69Trp | p.R69W | Q92888 | protein_coding | deleterious(0.01) | possibly_damaging(0.612) | TCGA-KK-A6E2-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
ARHGEF1 | SNV | Missense_Mutation | novel | c.2339C>T | p.Pro780Leu | p.P780L | Q92888 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
ARHGEF1 | SNV | Missense_Mutation | c.679G>A | p.Glu227Lys | p.E227K | Q92888 | protein_coding | deleterious(0.02) | possibly_damaging(0.565) | TCGA-BR-7715-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARHGEF1 | SNV | Missense_Mutation | novel | c.970N>C | p.Ser324Pro | p.S324P | Q92888 | protein_coding | tolerated(0.05) | benign(0.027) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ARHGEF1 | SNV | Missense_Mutation | c.1289N>C | p.Val430Ala | p.V430A | Q92888 | protein_coding | tolerated(0.15) | benign(0.007) | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR | |
ARHGEF1 | SNV | Missense_Mutation | c.1663N>A | p.Val555Met | p.V555M | Q92888 | protein_coding | tolerated(0.18) | probably_damaging(0.986) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ARHGEF1 | SNV | Missense_Mutation | c.820N>T | p.Ala274Ser | p.A274S | Q92888 | protein_coding | tolerated(0.71) | benign(0.014) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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