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Gene: ANLN |
Gene summary for ANLN |
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Gene information | Species | Human | Gene symbol | ANLN | Gene ID | 54443 |
Gene name | anillin actin binding protein | |
Gene Alias | FSGS8 | |
Cytomap | 7p14.2 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | Q9NQW6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54443 | ANLN | LZE2T | Human | Esophagus | ESCC | 9.54e-06 | 7.69e-01 | 0.082 |
54443 | ANLN | LZE4T | Human | Esophagus | ESCC | 1.70e-03 | 2.71e-01 | 0.0811 |
54443 | ANLN | LZE22T | Human | Esophagus | ESCC | 1.57e-03 | 3.80e-01 | 0.068 |
54443 | ANLN | LZE21T | Human | Esophagus | ESCC | 1.37e-06 | 5.57e-01 | 0.0655 |
54443 | ANLN | P2T-E | Human | Esophagus | ESCC | 7.08e-13 | 4.74e-01 | 0.1177 |
54443 | ANLN | P4T-E | Human | Esophagus | ESCC | 4.13e-17 | 4.77e-01 | 0.1323 |
54443 | ANLN | P5T-E | Human | Esophagus | ESCC | 3.28e-28 | 7.00e-01 | 0.1327 |
54443 | ANLN | P9T-E | Human | Esophagus | ESCC | 3.05e-07 | 2.99e-01 | 0.1131 |
54443 | ANLN | P10T-E | Human | Esophagus | ESCC | 7.37e-10 | 4.07e-01 | 0.116 |
54443 | ANLN | P11T-E | Human | Esophagus | ESCC | 9.07e-04 | 3.53e-01 | 0.1426 |
54443 | ANLN | P12T-E | Human | Esophagus | ESCC | 2.20e-13 | 3.13e-01 | 0.1122 |
54443 | ANLN | P15T-E | Human | Esophagus | ESCC | 7.07e-10 | 3.17e-01 | 0.1149 |
54443 | ANLN | P16T-E | Human | Esophagus | ESCC | 2.04e-04 | 1.98e-01 | 0.1153 |
54443 | ANLN | P17T-E | Human | Esophagus | ESCC | 1.49e-05 | 5.38e-01 | 0.1278 |
54443 | ANLN | P19T-E | Human | Esophagus | ESCC | 6.53e-04 | 4.54e-01 | 0.1662 |
54443 | ANLN | P20T-E | Human | Esophagus | ESCC | 8.24e-04 | 1.56e-01 | 0.1124 |
54443 | ANLN | P21T-E | Human | Esophagus | ESCC | 1.29e-11 | 6.66e-01 | 0.1617 |
54443 | ANLN | P22T-E | Human | Esophagus | ESCC | 1.16e-05 | 3.34e-01 | 0.1236 |
54443 | ANLN | P23T-E | Human | Esophagus | ESCC | 1.83e-07 | 3.85e-01 | 0.108 |
54443 | ANLN | P24T-E | Human | Esophagus | ESCC | 4.09e-07 | 2.61e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:190199013 | Esophagus | ESCC | regulation of mitotic cell cycle phase transition | 191/8552 | 299/18723 | 1.35e-10 | 3.94e-09 | 191 |
GO:000028115 | Esophagus | ESCC | mitotic cytokinesis | 58/8552 | 71/18723 | 4.34e-10 | 1.15e-08 | 58 |
GO:003250614 | Esophagus | ESCC | cytokinetic process | 35/8552 | 39/18723 | 9.38e-09 | 1.90e-07 | 35 |
GO:000091016 | Esophagus | ESCC | cytokinesis | 115/8552 | 173/18723 | 2.48e-08 | 4.68e-07 | 115 |
GO:006164015 | Esophagus | ESCC | cytoskeleton-dependent cytokinesis | 72/8552 | 100/18723 | 8.10e-08 | 1.39e-06 | 72 |
GO:003134616 | Esophagus | ESCC | positive regulation of cell projection organization | 201/8552 | 353/18723 | 1.19e-05 | 1.11e-04 | 201 |
GO:003086517 | Esophagus | ESCC | cortical cytoskeleton organization | 44/8552 | 61/18723 | 2.50e-05 | 2.13e-04 | 44 |
GO:006049118 | Esophagus | ESCC | regulation of cell projection assembly | 110/8552 | 188/18723 | 2.60e-04 | 1.58e-03 | 110 |
GO:012003218 | Esophagus | ESCC | regulation of plasma membrane bounded cell projection assembly | 108/8552 | 186/18723 | 4.37e-04 | 2.46e-03 | 108 |
GO:01200347 | Esophagus | ESCC | positive regulation of plasma membrane bounded cell projection assembly | 64/8552 | 105/18723 | 1.15e-03 | 5.70e-03 | 64 |
GO:000166720 | Esophagus | ESCC | ameboidal-type cell migration | 250/8552 | 475/18723 | 1.22e-03 | 5.97e-03 | 250 |
GO:003086610 | Esophagus | ESCC | cortical actin cytoskeleton organization | 28/8552 | 40/18723 | 1.61e-03 | 7.50e-03 | 28 |
GO:003103219 | Esophagus | ESCC | actomyosin structure organization | 108/8552 | 196/18723 | 4.86e-03 | 1.88e-02 | 108 |
GO:001063120 | Esophagus | ESCC | epithelial cell migration | 187/8552 | 357/18723 | 6.05e-03 | 2.23e-02 | 187 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANLN | SNV | Missense_Mutation | c.2545N>C | p.Ala849Pro | p.A849P | Q9NQW6 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-50-5049-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ANLN | SNV | Missense_Mutation | c.2163G>T | p.Gln721His | p.Q721H | Q9NQW6 | protein_coding | tolerated(0.07) | possibly_damaging(0.864) | TCGA-53-7624-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
ANLN | SNV | Missense_Mutation | c.2087A>C | p.Lys696Thr | p.K696T | Q9NQW6 | protein_coding | deleterious(0.05) | benign(0.164) | TCGA-55-8511-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ANLN | SNV | Missense_Mutation | c.2419N>A | p.Ser807Thr | p.S807T | Q9NQW6 | protein_coding | tolerated(0.14) | possibly_damaging(0.609) | TCGA-64-1678-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
ANLN | SNV | Missense_Mutation | c.458G>T | p.Arg153Leu | p.R153L | Q9NQW6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-75-6214-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | PD | |
ANLN | SNV | Missense_Mutation | c.1955N>C | p.Arg652Pro | p.R652P | Q9NQW6 | protein_coding | tolerated(0.06) | possibly_damaging(0.798) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD | |
ANLN | SNV | Missense_Mutation | c.235N>A | p.Val79Ile | p.V79I | Q9NQW6 | protein_coding | tolerated(0.18) | benign(0.001) | TCGA-91-6848-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR | |
ANLN | SNV | Missense_Mutation | novel | c.2795N>C | p.Ser932Thr | p.S932T | Q9NQW6 | protein_coding | deleterious(0.01) | benign(0.006) | TCGA-22-5481-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ANLN | SNV | Missense_Mutation | novel | c.682N>C | p.Glu228Gln | p.E228Q | Q9NQW6 | protein_coding | deleterious(0.04) | possibly_damaging(0.828) | TCGA-39-5040-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | PD |
ANLN | SNV | Missense_Mutation | c.892A>G | p.Lys298Glu | p.K298E | Q9NQW6 | protein_coding | tolerated(0.07) | benign(0.11) | TCGA-43-5668-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Other, specify in notesMAGE3-AS15-NSC-003 | clinical | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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