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Gene: ANKS1B |
Gene summary for ANKS1B |
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Gene information | Species | Human | Gene symbol | ANKS1B | Gene ID | 56899 |
Gene name | ankyrin repeat and sterile alpha motif domain containing 1B | |
Gene Alias | AIDA | |
Cytomap | 12q23.1 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | B7Z9I9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56899 | ANKS1B | AEH-subject1 | Human | Endometrium | AEH | 1.27e-13 | 3.50e-01 | -0.3059 |
56899 | ANKS1B | AEH-subject3 | Human | Endometrium | AEH | 2.38e-09 | 3.03e-01 | -0.2576 |
56899 | ANKS1B | AEH-subject4 | Human | Endometrium | AEH | 7.80e-05 | 2.67e-01 | -0.2657 |
56899 | ANKS1B | AEH-subject5 | Human | Endometrium | AEH | 9.88e-30 | 6.80e-01 | -0.2953 |
56899 | ANKS1B | EEC-subject1 | Human | Endometrium | EEC | 1.33e-27 | 6.25e-01 | -0.2682 |
56899 | ANKS1B | EEC-subject2 | Human | Endometrium | EEC | 3.95e-02 | 1.55e-01 | -0.2607 |
56899 | ANKS1B | EEC-subject4 | Human | Endometrium | EEC | 4.34e-04 | 2.18e-01 | -0.2571 |
56899 | ANKS1B | EEC-subject5 | Human | Endometrium | EEC | 2.69e-07 | 2.83e-01 | -0.249 |
56899 | ANKS1B | RNA-P17T-P17T-2 | Human | Lung | IAC | 1.63e-03 | 5.55e-01 | 0.3371 |
56899 | ANKS1B | RNA-P17T-P17T-4 | Human | Lung | IAC | 4.50e-10 | 9.22e-01 | 0.343 |
56899 | ANKS1B | RNA-P17T-P17T-6 | Human | Lung | IAC | 1.07e-03 | 6.18e-01 | 0.3385 |
56899 | ANKS1B | RNA-P17T-P17T-8 | Human | Lung | IAC | 7.12e-06 | 6.74e-01 | 0.3329 |
56899 | ANKS1B | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.00e-18 | 8.04e-01 | -0.2116 |
56899 | ANKS1B | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 4.54e-03 | 5.58e-01 | -0.1941 |
56899 | ANKS1B | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 2.57e-06 | 7.09e-01 | -0.2107 |
56899 | ANKS1B | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 3.81e-22 | 9.42e-01 | -0.2119 |
56899 | ANKS1B | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.33e-25 | 7.61e-01 | -0.0166 |
56899 | ANKS1B | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 2.70e-26 | 7.85e-01 | -0.0132 |
56899 | ANKS1B | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 2.37e-24 | 7.26e-01 | -0.013 |
56899 | ANKS1B | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.48e-21 | 7.40e-01 | -0.0121 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00315032 | Lung | IAC | protein-containing complex localization | 42/2061 | 220/18723 | 2.60e-04 | 4.32e-03 | 42 |
GO:003150311 | Lung | AIS | protein-containing complex localization | 39/1849 | 220/18723 | 2.24e-04 | 4.51e-03 | 39 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKS1B | SNV | Missense_Mutation | novel | c.534A>C | p.Lys178Asn | p.K178N | Q7Z6G8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ANKS1B | SNV | Missense_Mutation | c.3206N>A | p.Ser1069Tyr | p.S1069Y | Q7Z6G8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANKS1B | SNV | Missense_Mutation | novel | c.2233T>C | p.Tyr745His | p.Y745H | Q7Z6G8 | protein_coding | tolerated(0.19) | benign(0) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ANKS1B | SNV | Missense_Mutation | rs753545009 | c.605C>T | p.Ala202Val | p.A202V | Q7Z6G8 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ANKS1B | SNV | Missense_Mutation | novel | c.1264N>A | p.Leu422Ile | p.L422I | Q7Z6G8 | protein_coding | deleterious(0.03) | possibly_damaging(0.899) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ANKS1B | SNV | Missense_Mutation | novel | c.545N>A | p.Ser182Asn | p.S182N | Q7Z6G8 | protein_coding | tolerated(1) | benign(0.019) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ANKS1B | SNV | Missense_Mutation | novel | c.133N>C | p.Ser45Arg | p.S45R | Q7Z6G8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ANKS1B | SNV | Missense_Mutation | novel | c.2825N>A | p.Ser942Tyr | p.S942Y | Q7Z6G8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKS1B | SNV | Missense_Mutation | novel | c.2182N>A | p.Asp728Asn | p.D728N | Q7Z6G8 | protein_coding | deleterious(0) | possibly_damaging(0.532) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKS1B | SNV | Missense_Mutation | novel | c.265N>T | p.Asp89Tyr | p.D89Y | Q7Z6G8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
56899 | ANKS1B | NA | ethanol | ALCOHOL | 31462767 | |
56899 | ANKS1B | NA | methamphetamine | METHAMPHETAMINE | 31462767 | |
56899 | ANKS1B | NA | heroin | DIACETYLMORPHINE | 31462767 | |
56899 | ANKS1B | NA | amisulpride | AMISULPRIDE | 28332719 |
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