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Gene: ANKRD50 |
Gene summary for ANKRD50 |
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Gene information | Species | Human | Gene symbol | ANKRD50 | Gene ID | 57182 |
Gene name | ankyrin repeat domain 50 | |
Gene Alias | ANKRD50 | |
Cytomap | 4q28.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8TB46 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57182 | ANKRD50 | LZE4T | Human | Esophagus | ESCC | 1.18e-05 | 2.19e-01 | 0.0811 |
57182 | ANKRD50 | LZE5T | Human | Esophagus | ESCC | 4.10e-02 | 5.35e-01 | 0.0514 |
57182 | ANKRD50 | LZE8T | Human | Esophagus | ESCC | 1.12e-06 | 2.40e-01 | 0.067 |
57182 | ANKRD50 | LZE24T | Human | Esophagus | ESCC | 4.09e-08 | 1.62e-01 | 0.0596 |
57182 | ANKRD50 | P1T-E | Human | Esophagus | ESCC | 1.53e-02 | 2.65e-01 | 0.0875 |
57182 | ANKRD50 | P2T-E | Human | Esophagus | ESCC | 3.01e-16 | 1.50e-01 | 0.1177 |
57182 | ANKRD50 | P4T-E | Human | Esophagus | ESCC | 1.01e-13 | 2.17e-01 | 0.1323 |
57182 | ANKRD50 | P5T-E | Human | Esophagus | ESCC | 2.34e-05 | -1.43e-04 | 0.1327 |
57182 | ANKRD50 | P8T-E | Human | Esophagus | ESCC | 3.50e-12 | 2.56e-01 | 0.0889 |
57182 | ANKRD50 | P9T-E | Human | Esophagus | ESCC | 3.04e-06 | 5.87e-02 | 0.1131 |
57182 | ANKRD50 | P10T-E | Human | Esophagus | ESCC | 1.39e-10 | 1.14e-01 | 0.116 |
57182 | ANKRD50 | P11T-E | Human | Esophagus | ESCC | 1.43e-02 | 1.77e-01 | 0.1426 |
57182 | ANKRD50 | P12T-E | Human | Esophagus | ESCC | 3.29e-19 | 4.77e-01 | 0.1122 |
57182 | ANKRD50 | P15T-E | Human | Esophagus | ESCC | 2.75e-15 | 2.79e-01 | 0.1149 |
57182 | ANKRD50 | P16T-E | Human | Esophagus | ESCC | 1.19e-06 | 7.61e-02 | 0.1153 |
57182 | ANKRD50 | P20T-E | Human | Esophagus | ESCC | 4.40e-07 | 6.07e-02 | 0.1124 |
57182 | ANKRD50 | P21T-E | Human | Esophagus | ESCC | 1.07e-08 | 8.52e-02 | 0.1617 |
57182 | ANKRD50 | P22T-E | Human | Esophagus | ESCC | 3.91e-25 | 3.51e-01 | 0.1236 |
57182 | ANKRD50 | P23T-E | Human | Esophagus | ESCC | 1.20e-07 | 1.67e-01 | 0.108 |
57182 | ANKRD50 | P24T-E | Human | Esophagus | ESCC | 2.75e-03 | 9.14e-03 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
GO:009887615 | Esophagus | ESCC | vesicle-mediated transport to the plasma membrane | 99/8552 | 136/18723 | 1.13e-10 | 3.39e-09 | 99 |
GO:00324565 | Esophagus | ESCC | endocytic recycling | 51/8552 | 73/18723 | 2.47e-05 | 2.10e-04 | 51 |
GO:00988768 | Prostate | BPH | vesicle-mediated transport to the plasma membrane | 43/3107 | 136/18723 | 1.11e-05 | 1.51e-04 | 43 |
GO:00161978 | Prostate | BPH | endosomal transport | 62/3107 | 230/18723 | 4.54e-05 | 4.77e-04 | 62 |
GO:00324563 | Prostate | BPH | endocytic recycling | 21/3107 | 73/18723 | 6.45e-03 | 2.91e-02 | 21 |
GO:009887613 | Prostate | Tumor | vesicle-mediated transport to the plasma membrane | 42/3246 | 136/18723 | 7.47e-05 | 7.84e-04 | 42 |
GO:001619713 | Prostate | Tumor | endosomal transport | 62/3246 | 230/18723 | 1.65e-04 | 1.47e-03 | 62 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKRD50 | SNV | Missense_Mutation | rs764285889 | c.2344C>T | p.Arg782Cys | p.R782C | Q9ULJ7 | protein_coding | tolerated(0.05) | probably_damaging(0.987) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRD50 | SNV | Missense_Mutation | c.1580C>T | p.Ser527Phe | p.S527F | Q9ULJ7 | protein_coding | deleterious(0.01) | possibly_damaging(0.877) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANKRD50 | SNV | Missense_Mutation | rs376403231 | c.1406N>T | p.Ala469Val | p.A469V | Q9ULJ7 | protein_coding | tolerated(0.5) | benign(0.007) | TCGA-BG-A0YV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ANKRD50 | SNV | Missense_Mutation | c.1117N>A | p.Val373Ile | p.V373I | Q9ULJ7 | protein_coding | tolerated(0.18) | benign(0.027) | TCGA-BK-A0C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANKRD50 | SNV | Missense_Mutation | novel | c.3869A>C | p.Asn1290Thr | p.N1290T | Q9ULJ7 | protein_coding | tolerated_low_confidence(0.56) | benign(0.001) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRD50 | SNV | Missense_Mutation | c.3055N>A | p.Ala1019Thr | p.A1019T | Q9ULJ7 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-BS-A0UA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ANKRD50 | SNV | Missense_Mutation | rs748502338 | c.3451N>T | p.Arg1151Cys | p.R1151C | Q9ULJ7 | protein_coding | tolerated(0.11) | probably_damaging(0.985) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANKRD50 | SNV | Missense_Mutation | c.2579N>T | p.Arg860Ile | p.R860I | Q9ULJ7 | protein_coding | tolerated(0.41) | benign(0.09) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ANKRD50 | SNV | Missense_Mutation | rs780417292 | c.1085N>A | p.Arg362Gln | p.R362Q | Q9ULJ7 | protein_coding | tolerated(0.18) | benign(0.015) | TCGA-D1-A15Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANKRD50 | SNV | Missense_Mutation | c.2432A>T | p.Asp811Val | p.D811V | Q9ULJ7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D1-A16N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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