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Gene: ANKEF1 |
Gene summary for ANKEF1 |
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Gene information | Species | Human | Gene symbol | ANKEF1 | Gene ID | 63926 |
Gene name | ankyrin repeat and EF-hand domain containing 1 | |
Gene Alias | ANKRD5 | |
Cytomap | 20p12.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q9NU02 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
63926 | ANKEF1 | LZE4T | Human | Esophagus | ESCC | 9.66e-09 | 2.45e-01 | 0.0811 |
63926 | ANKEF1 | LZE20T | Human | Esophagus | ESCC | 3.16e-03 | 1.14e-01 | 0.0662 |
63926 | ANKEF1 | LZE22T | Human | Esophagus | ESCC | 1.57e-02 | 1.76e-01 | 0.068 |
63926 | ANKEF1 | LZE24T | Human | Esophagus | ESCC | 3.17e-06 | 1.75e-01 | 0.0596 |
63926 | ANKEF1 | LZE6T | Human | Esophagus | ESCC | 9.61e-05 | 1.88e-01 | 0.0845 |
63926 | ANKEF1 | P1T-E | Human | Esophagus | ESCC | 5.20e-08 | 2.61e-01 | 0.0875 |
63926 | ANKEF1 | P2T-E | Human | Esophagus | ESCC | 2.86e-20 | 3.36e-01 | 0.1177 |
63926 | ANKEF1 | P4T-E | Human | Esophagus | ESCC | 4.27e-09 | 2.06e-01 | 0.1323 |
63926 | ANKEF1 | P5T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.07e-01 | 0.1327 |
63926 | ANKEF1 | P8T-E | Human | Esophagus | ESCC | 3.50e-02 | 1.17e-01 | 0.0889 |
63926 | ANKEF1 | P9T-E | Human | Esophagus | ESCC | 3.05e-07 | 1.66e-01 | 0.1131 |
63926 | ANKEF1 | P10T-E | Human | Esophagus | ESCC | 4.12e-11 | 1.94e-01 | 0.116 |
63926 | ANKEF1 | P11T-E | Human | Esophagus | ESCC | 2.94e-14 | 5.22e-01 | 0.1426 |
63926 | ANKEF1 | P12T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.03e-01 | 0.1122 |
63926 | ANKEF1 | P15T-E | Human | Esophagus | ESCC | 7.99e-08 | 1.64e-01 | 0.1149 |
63926 | ANKEF1 | P16T-E | Human | Esophagus | ESCC | 4.40e-09 | 1.87e-01 | 0.1153 |
63926 | ANKEF1 | P17T-E | Human | Esophagus | ESCC | 7.64e-08 | 3.42e-01 | 0.1278 |
63926 | ANKEF1 | P20T-E | Human | Esophagus | ESCC | 2.16e-09 | 2.10e-01 | 0.1124 |
63926 | ANKEF1 | P21T-E | Human | Esophagus | ESCC | 3.95e-30 | 5.57e-01 | 0.1617 |
63926 | ANKEF1 | P22T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.41e-01 | 0.1236 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKEF1 | SNV | Missense_Mutation | rs766863397 | c.818G>A | p.Arg273Gln | p.R273Q | Q9NU02 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CH-5765-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
ANKEF1 | SNV | Missense_Mutation | c.87N>T | p.Glu29Asp | p.E29D | Q9NU02 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANKEF1 | SNV | Missense_Mutation | c.1991C>A | p.Pro664His | p.P664H | Q9NU02 | protein_coding | deleterious(0.01) | benign(0.187) | TCGA-BR-4363-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ANKEF1 | SNV | Missense_Mutation | c.2247G>T | p.Glu749Asp | p.E749D | Q9NU02 | protein_coding | tolerated(0.3) | benign(0.006) | TCGA-BR-4363-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ANKEF1 | SNV | Missense_Mutation | c.2141A>G | p.Lys714Arg | p.K714R | Q9NU02 | protein_coding | tolerated(0.08) | benign(0.012) | TCGA-CD-5801-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
ANKEF1 | SNV | Missense_Mutation | c.914N>A | p.Arg305Gln | p.R305Q | Q9NU02 | protein_coding | deleterious(0) | benign(0.038) | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD | |
ANKEF1 | SNV | Missense_Mutation | novel | c.952N>A | p.Ala318Thr | p.A318T | Q9NU02 | protein_coding | tolerated(0.1) | benign(0.054) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
ANKEF1 | SNV | Missense_Mutation | c.1399N>T | p.Arg467Trp | p.R467W | Q9NU02 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-VQ-A8P3-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | CR | |
ANKEF1 | SNV | Missense_Mutation | novel | c.667C>G | p.His223Asp | p.H223D | Q9NU02 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DJ-A13L-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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