![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ADGRF1 |
Gene summary for ADGRF1 |
![]() |
Gene information | Species | Human | Gene symbol | ADGRF1 | Gene ID | 266977 |
Gene name | adhesion G protein-coupled receptor F1 | |
Gene Alias | GPR110 | |
Cytomap | 6p12.3 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q3SXM8 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
266977 | ADGRF1 | CA_HPV_2 | Human | Cervix | CC | 3.32e-13 | 3.21e-01 | 0.0391 |
266977 | ADGRF1 | CCI_1 | Human | Cervix | CC | 1.88e-04 | 7.80e-01 | 0.528 |
266977 | ADGRF1 | H2 | Human | Cervix | HSIL_HPV | 3.57e-25 | 7.09e-01 | 0.0632 |
266977 | ADGRF1 | LZE5T | Human | Esophagus | ESCC | 1.28e-07 | 5.29e-01 | 0.0514 |
266977 | ADGRF1 | LZE8T | Human | Esophagus | ESCC | 2.13e-11 | 3.77e-01 | 0.067 |
266977 | ADGRF1 | LZE20T | Human | Esophagus | ESCC | 1.74e-07 | 2.52e-01 | 0.0662 |
266977 | ADGRF1 | LZE22T | Human | Esophagus | ESCC | 1.57e-02 | 4.31e-01 | 0.068 |
266977 | ADGRF1 | P1T-E | Human | Esophagus | ESCC | 3.58e-07 | 1.13e+00 | 0.0875 |
266977 | ADGRF1 | P8T-E | Human | Esophagus | ESCC | 1.61e-32 | 7.53e-01 | 0.0889 |
266977 | ADGRF1 | P23T-E | Human | Esophagus | ESCC | 6.47e-17 | 1.17e+00 | 0.108 |
266977 | ADGRF1 | P39T-E | Human | Esophagus | ESCC | 1.30e-15 | 4.08e-01 | 0.0894 |
266977 | ADGRF1 | P47T-E | Human | Esophagus | ESCC | 1.88e-04 | 2.59e-01 | 0.1067 |
266977 | ADGRF1 | P54T-E | Human | Esophagus | ESCC | 1.64e-05 | 2.65e-01 | 0.0975 |
266977 | ADGRF1 | P62T-E | Human | Esophagus | ESCC | 5.46e-06 | 4.03e-01 | 0.1302 |
266977 | ADGRF1 | P74T-E | Human | Esophagus | ESCC | 1.96e-03 | 2.19e-01 | 0.1479 |
266977 | ADGRF1 | P75T-E | Human | Esophagus | ESCC | 4.12e-11 | 4.39e-01 | 0.1125 |
266977 | ADGRF1 | P82T-E | Human | Esophagus | ESCC | 6.98e-18 | 1.44e+00 | 0.1072 |
266977 | ADGRF1 | P84T-E | Human | Esophagus | ESCC | 2.46e-07 | 7.12e-01 | 0.0933 |
266977 | ADGRF1 | P104T-E | Human | Esophagus | ESCC | 6.28e-04 | 2.72e-01 | 0.0931 |
266977 | ADGRF1 | P127T-E | Human | Esophagus | ESCC | 3.53e-27 | 8.48e-01 | 0.0826 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00343298 | Cervix | CC | cell junction assembly | 88/2311 | 420/18723 | 3.42e-07 | 1.38e-05 | 88 |
GO:00510904 | Cervix | CC | regulation of DNA-binding transcription factor activity | 87/2311 | 440/18723 | 4.85e-06 | 1.22e-04 | 87 |
GO:00510915 | Cervix | CC | positive regulation of DNA-binding transcription factor activity | 51/2311 | 260/18723 | 5.05e-04 | 4.92e-03 | 51 |
GO:005109012 | Cervix | HSIL_HPV | regulation of DNA-binding transcription factor activity | 35/737 | 440/18723 | 6.77e-05 | 1.58e-03 | 35 |
GO:005109112 | Cervix | HSIL_HPV | positive regulation of DNA-binding transcription factor activity | 24/737 | 260/18723 | 1.01e-04 | 2.16e-03 | 24 |
GO:003432913 | Cervix | HSIL_HPV | cell junction assembly | 28/737 | 420/18723 | 4.82e-03 | 3.98e-02 | 28 |
GO:00510908 | Esophagus | ESCC | regulation of DNA-binding transcription factor activity | 252/8552 | 440/18723 | 5.22e-07 | 6.97e-06 | 252 |
GO:00510918 | Esophagus | ESCC | positive regulation of DNA-binding transcription factor activity | 155/8552 | 260/18723 | 3.83e-06 | 4.14e-05 | 155 |
GO:003432918 | Esophagus | ESCC | cell junction assembly | 227/8552 | 420/18723 | 3.06e-04 | 1.83e-03 | 227 |
GO:00343297 | Lung | IAC | cell junction assembly | 86/2061 | 420/18723 | 7.98e-09 | 1.10e-06 | 86 |
GO:00510903 | Lung | IAC | regulation of DNA-binding transcription factor activity | 76/2061 | 440/18723 | 4.44e-05 | 1.05e-03 | 76 |
GO:00510914 | Lung | IAC | positive regulation of DNA-binding transcription factor activity | 50/2061 | 260/18723 | 5.87e-05 | 1.29e-03 | 50 |
GO:00508085 | Lung | IAC | synapse organization | 65/2061 | 426/18723 | 4.05e-03 | 3.31e-02 | 65 |
GO:003432912 | Lung | AIS | cell junction assembly | 84/1849 | 420/18723 | 2.16e-10 | 5.71e-08 | 84 |
GO:005080811 | Lung | AIS | synapse organization | 63/1849 | 426/18723 | 7.39e-04 | 1.07e-02 | 63 |
GO:005109011 | Lung | AIS | regulation of DNA-binding transcription factor activity | 64/1849 | 440/18723 | 1.04e-03 | 1.36e-02 | 64 |
GO:005109111 | Lung | AIS | positive regulation of DNA-binding transcription factor activity | 41/1849 | 260/18723 | 1.77e-03 | 2.01e-02 | 41 |
GO:00510907 | Oral cavity | OSCC | regulation of DNA-binding transcription factor activity | 221/7305 | 440/18723 | 9.06e-07 | 1.23e-05 | 221 |
GO:00510917 | Oral cavity | OSCC | positive regulation of DNA-binding transcription factor activity | 134/7305 | 260/18723 | 2.52e-05 | 2.35e-04 | 134 |
GO:003432916 | Oral cavity | OSCC | cell junction assembly | 190/7305 | 420/18723 | 4.99e-03 | 1.96e-02 | 190 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADGRF1 | SNV | Missense_Mutation | novel | c.2509N>C | p.Phe837Leu | p.F837L | Q5T601 | protein_coding | deleterious(0) | benign(0.444) | TCGA-DD-AAD6-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ADGRF1 | SNV | Missense_Mutation | novel | c.766C>A | p.Gln256Lys | p.Q256K | Q5T601 | protein_coding | tolerated(0.2) | benign(0.026) | TCGA-DD-AADB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ADGRF1 | SNV | Missense_Mutation | novel | c.764C>G | p.Ala255Gly | p.A255G | Q5T601 | protein_coding | deleterious(0) | possibly_damaging(0.5) | TCGA-DD-AADB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ADGRF1 | SNV | Missense_Mutation | novel | c.1271T>G | p.Phe424Cys | p.F424C | Q5T601 | protein_coding | deleterious(0.01) | benign(0.41) | TCGA-ZP-A9CV-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ADGRF1 | SNV | Missense_Mutation | novel | c.449N>T | p.Thr150Ile | p.T150I | Q5T601 | protein_coding | tolerated(0.26) | possibly_damaging(0.759) | TCGA-55-A4DG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ADGRF1 | SNV | Missense_Mutation | c.2084N>G | p.Gln695Arg | p.Q695R | Q5T601 | protein_coding | tolerated(0.62) | benign(0) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
ADGRF1 | SNV | Missense_Mutation | c.2083N>A | p.Gln695Lys | p.Q695K | Q5T601 | protein_coding | tolerated(1) | benign(0) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
ADGRF1 | SNV | Missense_Mutation | rs762278309 | c.1690A>G | p.Thr564Ala | p.T564A | Q5T601 | protein_coding | tolerated(0.09) | benign(0.038) | TCGA-21-1081-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ADGRF1 | SNV | Missense_Mutation | c.1092N>A | p.Phe364Leu | p.F364L | Q5T601 | protein_coding | tolerated(0.68) | benign(0.001) | TCGA-34-5928-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ADGRF1 | SNV | Missense_Mutation | c.409N>G | p.Leu137Val | p.L137V | Q5T601 | protein_coding | tolerated(0.19) | benign(0) | TCGA-39-5016-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |