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Gene: ADAMTS6 |
Gene summary for ADAMTS6 |
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Gene information | Species | Human | Gene symbol | ADAMTS6 | Gene ID | 11174 |
Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 6 | |
Gene Alias | ADAM-TS 6 | |
Cytomap | 5q12.3 | |
Gene Type | protein-coding | GO ID | GO:0001568 | UniProtAcc | Q5IR90 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11174 | ADAMTS6 | EEC-subject1 | Human | Endometrium | EEC | 2.88e-12 | 4.99e-01 | -0.2682 |
11174 | ADAMTS6 | EEC-subject2 | Human | Endometrium | EEC | 1.52e-02 | -9.27e-02 | -0.2607 |
11174 | ADAMTS6 | EEC-subject3 | Human | Endometrium | EEC | 1.97e-08 | -1.80e-01 | -0.2525 |
11174 | ADAMTS6 | EEC-subject4 | Human | Endometrium | EEC | 1.53e-02 | -1.68e-01 | -0.2571 |
11174 | ADAMTS6 | GSM5276934 | Human | Endometrium | EEC | 1.27e-07 | -2.21e-01 | -0.0913 |
11174 | ADAMTS6 | GSM5276935 | Human | Endometrium | EEC | 6.39e-04 | -1.97e-01 | -0.123 |
11174 | ADAMTS6 | GSM5276937 | Human | Endometrium | EEC | 1.78e-04 | -2.23e-01 | -0.0897 |
11174 | ADAMTS6 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.32e-07 | -2.46e-01 | -0.1869 |
11174 | ADAMTS6 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 4.09e-04 | -2.35e-01 | -0.1875 |
11174 | ADAMTS6 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 6.16e-07 | -2.28e-01 | -0.1883 |
11174 | ADAMTS6 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 6.78e-08 | 4.45e-01 | -0.1934 |
11174 | ADAMTS6 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 8.79e-11 | -2.12e-01 | -0.1917 |
11174 | ADAMTS6 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 5.04e-09 | -1.45e-01 | -0.1916 |
11174 | ADAMTS6 | ATC09 | Human | Thyroid | ATC | 4.41e-17 | 6.18e-01 | 0.2871 |
11174 | ADAMTS6 | ATC11 | Human | Thyroid | ATC | 2.95e-18 | 1.95e+00 | 0.3386 |
11174 | ADAMTS6 | ATC12 | Human | Thyroid | ATC | 2.23e-73 | 1.87e+00 | 0.34 |
11174 | ADAMTS6 | ATC13 | Human | Thyroid | ATC | 9.50e-14 | 2.87e-01 | 0.34 |
11174 | ADAMTS6 | ATC1 | Human | Thyroid | ATC | 6.77e-17 | 6.71e-01 | 0.2878 |
11174 | ADAMTS6 | ATC2 | Human | Thyroid | ATC | 2.40e-15 | 1.33e+00 | 0.34 |
11174 | ADAMTS6 | ATC3 | Human | Thyroid | ATC | 3.73e-38 | 2.28e+00 | 0.338 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000165512 | Endometrium | EEC | urogenital system development | 69/2168 | 338/18723 | 1.70e-06 | 5.18e-05 | 69 |
GO:007200112 | Endometrium | EEC | renal system development | 63/2168 | 302/18723 | 2.24e-06 | 6.59e-05 | 63 |
GO:000182212 | Endometrium | EEC | kidney development | 59/2168 | 293/18723 | 1.44e-05 | 2.87e-04 | 59 |
GO:003019812 | Thyroid | ATC | extracellular matrix organization | 152/6293 | 301/18723 | 8.63e-10 | 2.24e-08 | 152 |
GO:004306212 | Thyroid | ATC | extracellular structure organization | 152/6293 | 302/18723 | 1.17e-09 | 2.94e-08 | 152 |
GO:004522912 | Thyroid | ATC | external encapsulating structure organization | 152/6293 | 304/18723 | 2.11e-09 | 5.08e-08 | 152 |
GO:000182222 | Thyroid | ATC | kidney development | 146/6293 | 293/18723 | 5.81e-09 | 1.28e-07 | 146 |
GO:000165522 | Thyroid | ATC | urogenital system development | 164/6293 | 338/18723 | 7.92e-09 | 1.70e-07 | 164 |
GO:007200122 | Thyroid | ATC | renal system development | 149/6293 | 302/18723 | 9.48e-09 | 1.99e-07 | 149 |
GO:000327912 | Thyroid | ATC | cardiac septum development | 56/6293 | 103/18723 | 1.14e-05 | 1.11e-04 | 56 |
GO:000320512 | Thyroid | ATC | cardiac chamber development | 79/6293 | 161/18723 | 3.39e-05 | 2.80e-04 | 79 |
GO:00608401 | Thyroid | ATC | artery development | 48/6293 | 100/18723 | 1.97e-03 | 9.52e-03 | 48 |
GO:0035904 | Thyroid | ATC | aorta development | 30/6293 | 58/18723 | 3.31e-03 | 1.48e-02 | 30 |
GO:0060976 | Thyroid | ATC | coronary vasculature development | 24/6293 | 46/18723 | 7.13e-03 | 2.82e-02 | 24 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAMTS6 | SNV | Missense_Mutation | novel | c.1155N>C | p.Arg385Ser | p.R385S | Q9UKP5 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-78-7161-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
ADAMTS6 | SNV | Missense_Mutation | novel | c.1814N>A | p.Arg605His | p.R605H | Q9UKP5 | protein_coding | deleterious(0.02) | possibly_damaging(0.846) | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
ADAMTS6 | SNV | Missense_Mutation | novel | c.2758N>T | p.Arg920Cys | p.R920C | Q9UKP5 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-J2-A4AD-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ADAMTS6 | SNV | Missense_Mutation | c.3132N>T | p.Gln1044His | p.Q1044H | Q9UKP5 | protein_coding | tolerated(0.09) | benign(0.078) | TCGA-L9-A8F4-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ADAMTS6 | SNV | Missense_Mutation | c.50C>T | p.Ala17Val | p.A17V | Q9UKP5 | protein_coding | tolerated(0.68) | benign(0) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ADAMTS6 | SNV | Missense_Mutation | rs142650468 | c.1727G>A | p.Gly576Glu | p.G576E | Q9UKP5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ADAMTS6 | SNV | Missense_Mutation | novel | c.1892C>A | p.Pro631His | p.P631H | Q9UKP5 | protein_coding | deleterious(0) | possibly_damaging(0.882) | TCGA-21-1080-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ADAMTS6 | SNV | Missense_Mutation | novel | c.694C>A | p.Pro232Thr | p.P232T | Q9UKP5 | protein_coding | tolerated(0.13) | benign(0.005) | TCGA-21-5783-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ADAMTS6 | SNV | Missense_Mutation | novel | c.1671A>G | p.Ile557Met | p.I557M | Q9UKP5 | protein_coding | deleterious(0) | benign(0.089) | TCGA-22-5483-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | taxol | PD |
ADAMTS6 | SNV | Missense_Mutation | novel | c.36N>T | p.Leu12Phe | p.L12F | Q9UKP5 | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-33-4589-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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