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Gene: ADAMTS4 |
Gene summary for ADAMTS4 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ADAMTS4 | Gene ID | 9507 |
Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 4 | |
Gene Alias | ADAMTS-2 | |
Cytomap | 1q23.3 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | O75173 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9507 | ADAMTS4 | P2T-E | Human | Esophagus | ESCC | 2.28e-09 | 1.51e-01 | 0.1177 |
9507 | ADAMTS4 | P8T-E | Human | Esophagus | ESCC | 1.10e-02 | -3.07e-02 | 0.0889 |
9507 | ADAMTS4 | P10T-E | Human | Esophagus | ESCC | 2.84e-03 | 3.79e-03 | 0.116 |
9507 | ADAMTS4 | P16T-E | Human | Esophagus | ESCC | 1.58e-10 | 1.40e-01 | 0.1153 |
9507 | ADAMTS4 | P21T-E | Human | Esophagus | ESCC | 9.18e-05 | 1.41e-02 | 0.1617 |
9507 | ADAMTS4 | P24T-E | Human | Esophagus | ESCC | 7.05e-04 | 7.96e-02 | 0.1287 |
9507 | ADAMTS4 | P52T-E | Human | Esophagus | ESCC | 6.64e-21 | 5.49e-01 | 0.1555 |
9507 | ADAMTS4 | P56T-E | Human | Esophagus | ESCC | 5.22e-09 | 1.81e+00 | 0.1613 |
9507 | ADAMTS4 | P76T-E | Human | Esophagus | ESCC | 2.76e-02 | 1.47e-01 | 0.1207 |
9507 | ADAMTS4 | P80T-E | Human | Esophagus | ESCC | 4.08e-11 | 8.34e-01 | 0.155 |
9507 | ADAMTS4 | P130T-E | Human | Esophagus | ESCC | 5.21e-09 | 1.77e-01 | 0.1676 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:00301984 | Esophagus | ESCC | extracellular matrix organization | 171/8552 | 301/18723 | 6.08e-05 | 4.67e-04 | 171 |
GO:00430624 | Esophagus | ESCC | extracellular structure organization | 171/8552 | 302/18723 | 7.73e-05 | 5.76e-04 | 171 |
GO:00452294 | Esophagus | ESCC | external encapsulating structure organization | 172/8552 | 304/18723 | 7.80e-05 | 5.80e-04 | 172 |
GO:00226172 | Esophagus | ESCC | extracellular matrix disassembly | 39/8552 | 63/18723 | 6.92e-03 | 2.52e-02 | 39 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAMTS4 | SNV | Missense_Mutation | c.466N>T | p.Arg156Trp | p.R156W | O75173 | protein_coding | deleterious(0.03) | possibly_damaging(0.892) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ADAMTS4 | SNV | Missense_Mutation | c.1154N>A | p.Ser385Asn | p.S385N | O75173 | protein_coding | tolerated(0.44) | benign(0.001) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ADAMTS4 | SNV | Missense_Mutation | rs114600134 | c.2501C>T | p.Ala834Val | p.A834V | O75173 | protein_coding | tolerated_low_confidence(0.52) | benign(0) | TCGA-HJ-7597-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR |
ADAMTS4 | SNV | Missense_Mutation | c.1752G>T | p.Glu584Asp | p.E584D | O75173 | protein_coding | deleterious(0.02) | benign(0.443) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD | |
ADAMTS4 | SNV | Missense_Mutation | novel | c.2318N>A | p.Gly773Asp | p.G773D | O75173 | protein_coding | deleterious(0.01) | possibly_damaging(0.893) | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ADAMTS4 | SNV | Missense_Mutation | c.775N>T | p.Arg259Cys | p.R259C | O75173 | protein_coding | deleterious(0.01) | benign(0.012) | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ADAMTS4 | SNV | Missense_Mutation | rs778329496 | c.1339N>T | p.Arg447Cys | p.R447C | O75173 | protein_coding | deleterious(0) | possibly_damaging(0.768) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
ADAMTS4 | SNV | Missense_Mutation | rs114600134 | c.2501N>T | p.Ala834Val | p.A834V | O75173 | protein_coding | tolerated_low_confidence(0.52) | benign(0) | TCGA-VQ-A8PX-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9507 | ADAMTS4 | ENZYME, DRUGGABLE GENOME, NEUTRAL ZINC METALLOPEPTIDASE, PROTEASE | CHONDROITIN SULFATE | 14701864 | ||
9507 | ADAMTS4 | ENZYME, DRUGGABLE GENOME, NEUTRAL ZINC METALLOPEPTIDASE, PROTEASE | 1607004-34-1 | |||
9507 | ADAMTS4 | ENZYME, DRUGGABLE GENOME, NEUTRAL ZINC METALLOPEPTIDASE, PROTEASE | inhibitor | 252166754 | ||
9507 | ADAMTS4 | ENZYME, DRUGGABLE GENOME, NEUTRAL ZINC METALLOPEPTIDASE, PROTEASE | US9206139, 4 | |||
9507 | ADAMTS4 | ENZYME, DRUGGABLE GENOME, NEUTRAL ZINC METALLOPEPTIDASE, PROTEASE | US9206139, 5 |
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