![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZFHX4 |
Gene summary for ZFHX4 |
![]() |
Gene information | Species | Human | Gene symbol | ZFHX4 | Gene ID | 79776 |
Gene name | zinc finger homeobox 4 | |
Gene Alias | ZFH4 | |
Cytomap | 8q21.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q86UP3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79776 | ZFHX4 | P1T-E | Human | Esophagus | ESCC | 5.20e-08 | 3.43e-01 | 0.0875 |
79776 | ZFHX4 | P5T-E | Human | Esophagus | ESCC | 3.76e-04 | 9.90e-02 | 0.1327 |
79776 | ZFHX4 | P9T-E | Human | Esophagus | ESCC | 5.23e-05 | 1.38e-01 | 0.1131 |
79776 | ZFHX4 | P10T-E | Human | Esophagus | ESCC | 3.29e-21 | 4.45e-01 | 0.116 |
79776 | ZFHX4 | P11T-E | Human | Esophagus | ESCC | 3.25e-05 | 2.03e-01 | 0.1426 |
79776 | ZFHX4 | P15T-E | Human | Esophagus | ESCC | 8.45e-04 | 1.24e-01 | 0.1149 |
79776 | ZFHX4 | P16T-E | Human | Esophagus | ESCC | 2.22e-05 | 8.99e-02 | 0.1153 |
79776 | ZFHX4 | P23T-E | Human | Esophagus | ESCC | 6.91e-16 | 4.27e-01 | 0.108 |
79776 | ZFHX4 | P24T-E | Human | Esophagus | ESCC | 8.72e-07 | 1.08e-01 | 0.1287 |
79776 | ZFHX4 | P26T-E | Human | Esophagus | ESCC | 1.63e-05 | 1.11e-01 | 0.1276 |
79776 | ZFHX4 | P27T-E | Human | Esophagus | ESCC | 8.49e-09 | 2.07e-01 | 0.1055 |
79776 | ZFHX4 | P30T-E | Human | Esophagus | ESCC | 2.31e-10 | 3.75e-01 | 0.137 |
79776 | ZFHX4 | P36T-E | Human | Esophagus | ESCC | 4.17e-05 | 2.13e-01 | 0.1187 |
79776 | ZFHX4 | P37T-E | Human | Esophagus | ESCC | 3.53e-03 | 1.09e-01 | 0.1371 |
79776 | ZFHX4 | P42T-E | Human | Esophagus | ESCC | 1.02e-24 | 6.57e-01 | 0.1175 |
79776 | ZFHX4 | P47T-E | Human | Esophagus | ESCC | 1.94e-02 | 6.53e-02 | 0.1067 |
79776 | ZFHX4 | P49T-E | Human | Esophagus | ESCC | 3.75e-07 | 6.69e-01 | 0.1768 |
79776 | ZFHX4 | P62T-E | Human | Esophagus | ESCC | 1.57e-81 | 1.32e+00 | 0.1302 |
79776 | ZFHX4 | P74T-E | Human | Esophagus | ESCC | 2.69e-24 | 5.65e-01 | 0.1479 |
79776 | ZFHX4 | P75T-E | Human | Esophagus | ESCC | 2.25e-19 | 3.95e-01 | 0.1125 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFHX4 | SNV | Missense_Mutation | novel | c.2770N>T | p.Val924Leu | p.V924L | Q86UP3 | protein_coding | tolerated(0.56) | probably_damaging(0.987) | TCGA-56-8307-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFHX4 | SNV | Missense_Mutation | novel | c.5254N>G | p.Pro1752Ala | p.P1752A | Q86UP3 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-56-8307-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFHX4 | SNV | Missense_Mutation | novel | c.2209N>A | p.Gln737Lys | p.Q737K | Q86UP3 | protein_coding | deleterious(0.05) | benign(0.014) | TCGA-56-8504-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZFHX4 | SNV | Missense_Mutation | novel | c.6790N>G | p.Asn2264Asp | p.N2264D | Q86UP3 | protein_coding | deleterious(0.01) | possibly_damaging(0.655) | TCGA-56-8628-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZFHX4 | SNV | Missense_Mutation | novel | c.9827N>A | p.Pro3276His | p.P3276H | Q86UP3 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-56-8628-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZFHX4 | SNV | Missense_Mutation | novel | c.5566N>G | p.Lys1856Glu | p.K1856E | Q86UP3 | protein_coding | tolerated(0.07) | benign(0.298) | TCGA-56-A4ZK-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZFHX4 | SNV | Missense_Mutation | c.1756N>A | p.Ala586Thr | p.A586T | Q86UP3 | protein_coding | tolerated(0.54) | benign(0) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZFHX4 | SNV | Missense_Mutation | rs369317859 | c.8105G>T | p.Gly2702Val | p.G2702V | Q86UP3 | protein_coding | deleterious(0.01) | possibly_damaging(0.882) | TCGA-58-8386-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ZFHX4 | SNV | Missense_Mutation | novel | c.2521G>A | p.Asp841Asn | p.D841N | Q86UP3 | protein_coding | deleterious(0.03) | benign(0.225) | TCGA-58-8392-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZFHX4 | SNV | Missense_Mutation | c.1090T>A | p.Trp364Arg | p.W364R | Q86UP3 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-60-2703-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |