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Gene: ZSCAN18 |
Gene summary for ZSCAN18 |
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Gene information | Species | Human | Gene symbol | ZSCAN18 | Gene ID | 65982 |
Gene name | zinc finger and SCAN domain containing 18 | |
Gene Alias | ZNF447 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8TBC5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65982 | ZSCAN18 | LZE20T | Human | Esophagus | ESCC | 9.77e-09 | 2.08e-01 | 0.0662 |
65982 | ZSCAN18 | P2T-E | Human | Esophagus | ESCC | 1.27e-28 | 3.79e-01 | 0.1177 |
65982 | ZSCAN18 | P8T-E | Human | Esophagus | ESCC | 6.56e-41 | 6.09e-01 | 0.0889 |
65982 | ZSCAN18 | P10T-E | Human | Esophagus | ESCC | 3.94e-14 | 2.55e-01 | 0.116 |
65982 | ZSCAN18 | P11T-E | Human | Esophagus | ESCC | 3.08e-13 | 5.78e-01 | 0.1426 |
65982 | ZSCAN18 | P15T-E | Human | Esophagus | ESCC | 2.90e-08 | 1.89e-01 | 0.1149 |
65982 | ZSCAN18 | P16T-E | Human | Esophagus | ESCC | 1.19e-27 | 5.36e-01 | 0.1153 |
65982 | ZSCAN18 | P21T-E | Human | Esophagus | ESCC | 2.89e-09 | 1.99e-01 | 0.1617 |
65982 | ZSCAN18 | P22T-E | Human | Esophagus | ESCC | 6.05e-26 | 4.55e-01 | 0.1236 |
65982 | ZSCAN18 | P24T-E | Human | Esophagus | ESCC | 2.80e-11 | 2.88e-01 | 0.1287 |
65982 | ZSCAN18 | P28T-E | Human | Esophagus | ESCC | 3.00e-06 | 1.60e-01 | 0.1149 |
65982 | ZSCAN18 | P30T-E | Human | Esophagus | ESCC | 7.90e-07 | 2.03e-01 | 0.137 |
65982 | ZSCAN18 | P36T-E | Human | Esophagus | ESCC | 9.59e-05 | 1.84e-01 | 0.1187 |
65982 | ZSCAN18 | P38T-E | Human | Esophagus | ESCC | 5.83e-07 | 2.52e-01 | 0.127 |
65982 | ZSCAN18 | P39T-E | Human | Esophagus | ESCC | 1.48e-09 | 1.90e-01 | 0.0894 |
65982 | ZSCAN18 | P42T-E | Human | Esophagus | ESCC | 2.30e-02 | 1.33e-01 | 0.1175 |
65982 | ZSCAN18 | P44T-E | Human | Esophagus | ESCC | 5.20e-07 | 2.04e-01 | 0.1096 |
65982 | ZSCAN18 | P47T-E | Human | Esophagus | ESCC | 4.29e-02 | 9.47e-02 | 0.1067 |
65982 | ZSCAN18 | P52T-E | Human | Esophagus | ESCC | 4.93e-12 | 3.04e-01 | 0.1555 |
65982 | ZSCAN18 | P56T-E | Human | Esophagus | ESCC | 1.33e-02 | 7.47e-01 | 0.1613 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZSCAN18 | deletion | Frame_Shift_Del | novel | c.1600delN | p.Gln534AsnfsTer49 | p.Q534Nfs*49 | Q8TBC5 | protein_coding | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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