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Gene: ZNF737 |
Gene summary for ZNF737 |
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Gene information | Species | Human | Gene symbol | ZNF737 | Gene ID | 100129842 |
Gene name | zinc finger protein 737 | |
Gene Alias | ZNF102 | |
Cytomap | 19p12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O75373 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100129842 | ZNF737 | HCC1 | Human | Liver | HCC | 2.39e-18 | 2.37e+00 | 0.5336 |
100129842 | ZNF737 | HCC2 | Human | Liver | HCC | 8.12e-29 | 2.44e+00 | 0.5341 |
100129842 | ZNF737 | HCC5 | Human | Liver | HCC | 3.48e-26 | 1.70e+00 | 0.4932 |
100129842 | ZNF737 | male-WTA | Human | Thyroid | PTC | 1.04e-12 | 1.87e-01 | 0.1037 |
100129842 | ZNF737 | PTC01 | Human | Thyroid | PTC | 9.89e-03 | 4.18e-02 | 0.1899 |
100129842 | ZNF737 | PTC03 | Human | Thyroid | PTC | 6.94e-04 | 1.80e-01 | 0.1784 |
100129842 | ZNF737 | PTC04 | Human | Thyroid | PTC | 7.32e-09 | 1.12e-01 | 0.1927 |
100129842 | ZNF737 | PTC05 | Human | Thyroid | PTC | 7.54e-06 | 2.28e-01 | 0.2065 |
100129842 | ZNF737 | PTC06 | Human | Thyroid | PTC | 7.62e-07 | 1.74e-01 | 0.2057 |
100129842 | ZNF737 | PTC07 | Human | Thyroid | PTC | 5.96e-08 | 2.18e-01 | 0.2044 |
100129842 | ZNF737 | ATC13 | Human | Thyroid | ATC | 1.96e-15 | 1.31e-01 | 0.34 |
100129842 | ZNF737 | ATC5 | Human | Thyroid | ATC | 1.29e-07 | 1.44e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF737 | SNV | Missense_Mutation | novel | c.701N>A | p.Cys234Tyr | p.C234Y | O75373 | protein_coding | deleterious(0.02) | possibly_damaging(0.852) | TCGA-QK-A6II-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
ZNF737 | SNV | Missense_Mutation | rs782281537 | c.992A>G | p.His331Arg | p.H331R | O75373 | protein_coding | deleterious(0.01) | possibly_damaging(0.744) | TCGA-QK-AA3K-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
ZNF737 | SNV | Missense_Mutation | novel | c.103G>C | p.Glu35Gln | p.E35Q | O75373 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-T2-A6WX-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
ZNF737 | SNV | Missense_Mutation | c.1098N>C | p.Glu366Asp | p.E366D | O75373 | protein_coding | deleterious(0.02) | benign(0.098) | TCGA-T3-A92M-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ZNF737 | SNV | Missense_Mutation | novel | c.733N>T | p.Thr245Ser | p.T245S | O75373 | protein_coding | tolerated(0.16) | benign(0.023) | TCGA-UF-A719-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF737 | deletion | Frame_Shift_Del | novel | c.572delN | p.His191LeufsTer59 | p.H191Lfs*59 | O75373 | protein_coding | TCGA-CX-7082-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF737 | SNV | Missense_Mutation | novel | c.1367N>G | p.Glu456Gly | p.E456G | O75373 | protein_coding | deleterious(0.01) | possibly_damaging(0.852) | TCGA-BR-7723-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | PD |
ZNF737 | SNV | Missense_Mutation | rs782226892 | c.526A>G | p.Ile176Val | p.I176V | O75373 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-BR-8289-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
ZNF737 | SNV | Missense_Mutation | novel | c.151G>T | p.Asp51Tyr | p.D51Y | O75373 | protein_coding | deleterious(0.02) | possibly_damaging(0.885) | TCGA-BR-8676-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
ZNF737 | SNV | Missense_Mutation | rs782320412 | c.1166G>T | p.Arg389Ile | p.R389I | O75373 | protein_coding | tolerated(0.43) | benign(0.021) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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